| A Mediator-cohesin axis controls heterochromatin domain formation. | A Mediator-cohesin axis controls heterochromatin domain formation.
Haarhuis JHI, van der Weide RH, Blomen VA, Flach KD, Teunissen H, Willems L, Brummelkamp TR, Rowland BD, de Wit E., Free PMC Article | 03/5/2022 |
| WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7. | WAPL induces cervical intraepithelial neoplasia modulated with estrogen signaling without HPV E6/E7.
Kumagai K, Takanashi M, Ohno SI, Harada Y, Fujita K, Oikawa K, Sudo K, Ikeda SI, Nishi H, Oikawa K, Kuroda M., Free PMC Article | 01/22/2022 |
| ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL. | ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesin(STAG1) from WAPL.
Wutz G, Ladurner R, St Hilaire BG, Stocsits RR, Nagasaka K, Pignard B, Sanborn A, Tang W, Várnai C, Ivanov MP, Schoenfelder S, van der Lelij P, Huang X, Dürnberger G, Roitinger E, Mechtler K, Davidson IF, Fraser P, Lieberman-Aiden E, Peters JM., Free PMC Article | 05/1/2021 |
| WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion. | WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.
Benedict B, van Schie JJM, Oostra AB, Balk JA, Wolthuis RMF, Riele HT, de Lange J. | 10/24/2020 |
| Absolute copy numbers and dynamics of cohesin, CTCF, NIPBL, WAPL and sororin were measured by mass spectrometry, fluorescence-correlation spectroscopy and fluorescence recovery after photobleaching in HeLa cells. | Absolute quantification of cohesin, CTCF and their regulators in human cells.
Holzmann J, Politi AZ, Nagasaka K, Hantsche-Grininger M, Walther N, Koch B, Fuchs J, Dürnberger G, Tang W, Ladurner R, Stocsits RR, Busslinger GA, Novák B, Mechtler K, Davidson IF, Ellenberg J, Peters JM., Free PMC Article | 02/29/2020 |
| In p53-compromised cells we find that lethal replication stress confers WAPL-dependent centromere cohesion defects that maintain spindle assembly checkpoint-dependent mitotic arrest in the same cell cycle. | Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection.
Masamsetti VP, Low RRJ, Mak KS, O'Connor A, Riffkin CD, Lamm N, Crabbe L, Karlseder J, Huang DCS, Hayashi MT, Cesare AJ., Free PMC Article | 01/11/2020 |
| Rec8-Stag3 cohesin is shown to be susceptible to Wapl-dependent ring opening and sororin-mediated protection. | Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin.
Wolf PG, Cuba Ramos A, Kenzel J, Neumann B, Stemmann O. | 12/7/2019 |
| We provide evidence that the underlying mechanism involves the viral NS3/4 protease and the cohesin regulator, WAPL | Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions.
Perez S, Gevor M, Davidovich A, Kaspi A, Yamin K, Domovich T, Meirson T, Matityahu A, Brody Y, Stemmer SM, El-Osta A, Haviv I, Onn I, Gal-Tanamy M., Free PMC Article | 10/19/2019 |
| The results indicate a kinase-dependent role for Haspin in antagonizing Wapl and protecting centromeric cohesion in mitosis. | A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.
Liang C, Chen Q, Yi Q, Zhang M, Yan H, Zhang B, Zhou L, Zhang Z, Qi F, Ye S, Wang F., Free PMC Article | 01/5/2019 |
| The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL. | Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.
Wutz G, Várnai C, Nagasaka K, Cisneros DA, Stocsits RR, Tang W, Schoenfelder S, Jessberger G, Muhar M, Hossain MJ, Walther N, Koch B, Kueblbeck M, Ellenberg J, Zuber J, Fraser P, Peters JM., Free PMC Article | 12/30/2017 |
| Study shows that chromatin loop size can be increased and that the duration with which cohesin embraces DNA determines the degree to which loops are enlarged. Cohesin's DNA release factor WAPL restricts this loop extension and also prevents looping between incorrectly oriented CTCF sites. | The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.
Haarhuis JHI, van der Weide RH, Blomen VA, Yáñez-Cuna JO, Amendola M, van Ruiten MS, Krijger PHL, Teunissen H, Medema RH, van Steensel B, Brummelkamp TR, de Wit E, Rowland BD., Free PMC Article | 07/8/2017 |
| Rs7083506 and rs11202058 polymorphisms of hWAPL and their haplotype T-A were associated with cervical cancer. | Relationship between hWAPL polymorphisms and cervical cancer susceptibility.
Li L, Jiao GL, Qin S, Xiao Q., Free PMC Article | 12/17/2016 |
| WAPL-depleted cells undergo anaphase with segregation errors, resulting in micronuclei and DNA damage. Stable WAPL depletion arrests cells in a p53-dependent manner but causes p53-deficient cells to become highly aneuploid. | WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy.
Haarhuis JH, Elbatsh AM, van den Broek B, Camps D, Erkan H, Jalink K, Medema RH, Rowland BD. | 10/3/2015 |
| Wapl-C interacts with other cohesin subunits and possibly unknown effectors to trigger cohesin release from chromatin | Structure of the human cohesin inhibitor Wapl.
Ouyang Z, Zheng G, Song J, Borek DM, Otwinowski Z, Brautigam CA, Tomchick DR, Rankin S, Yu H., Free PMC Article | 10/19/2013 |
| Depletion of Wapl, a negative cohesin regulator, rescues sister chromatid homologous recombination defects of Mms21-deficient or Scc1 mutant-expressing cells | Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.
Wu N, Kong X, Ji Z, Zeng W, Potts PR, Yokomori K, Yu H., Free PMC Article | 09/15/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A., Free PMC Article | 12/2/2009 |
| isolated a large number of additional alternatively spliced WAPL variants from various cervical epithelia. Each variant consists of a variable 5'-terminal region and the conserved remainder. | Expression of various types of alternatively spliced WAPL transcripts in human cervical epithelia.
Oikawa K, Akiyoshi A, Tanaka M, Takanashi M, Nishi H, Isaka K, Kiseki H, Idei T, Tsukahara Y, Hashimura N, Mukai K, Kuroda M. | 01/21/2010 |
| Wapl is required to unlock cohesin from a particular state in which it is stably bound to chromatin. | Wapl controls the dynamic association of cohesin with chromatin.
Kueng S, Hegemann B, Peters BH, Lipp JJ, Schleiffer A, Mechtler K, Peters JM. | 01/21/2010 |
| our study suggests that unscheduled overexpression of WAPL disturbs mitosis and cytokinesis, and contributes to tumor progression by induction of chromosomal instability. | Unscheduled overexpression of human WAPL promotes chromosomal instability.
Ohbayashi T, Oikawa K, Yamada K, Nishida-Umehara C, Matsuda Y, Satoh H, Mukai H, Mukai K, Kuroda M. | 01/21/2010 |
| Wapl is a new regulator of sister chromatid resolution and promotes release of cohesin from chromosomes by directly interacting with its regulatory subunits | Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.
Gandhi R, Gillespie PJ, Hirano T., Free PMC Article | 01/21/2010 |
| FOE encodes a protein of 1227 amino acids with a functional bipartite nuclear localization signal, an arginine-rich motif, a putative nuclear export signal as well as with three highly acidic regions and a predicted coiled-coil domain. | Identification and cloning of a novel chromatin-associated protein partner of Epstein-Barr nuclear protein 2.
Kwiatkowski BA, Ragoczy T, Ehly J, Schubach WH. | 01/21/2010 |