| Multi-regulatory potency of USP1 on inflammasome components promotes pyroptosis in thyroid follicular cells and contributes to the progression of Hashimoto's thyroiditis. | Multi-regulatory potency of USP1 on inflammasome components promotes pyroptosis in thyroid follicular cells and contributes to the progression of Hashimoto's thyroiditis.
Zhao X, Ni W, Zheng W, Ni W, Sun C, Gu Y, Gu Z., Free PMC Article | 09/23/2024 |
| A genome-wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock. | A genome-wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock.
Hu Y, Li X, Zhang J, Liu D, Lu R, Li JD. | 02/7/2024 |
| The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses. | The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and Facilitates Antiviral Responses.
Yu Z, Tong L, Ma C, Song H, Wang J, Chai L, Wang C, Wang M, Wang C, Yan R, Fu Y, Jia M, Zhao W, Zhao C. | 01/9/2024 |
| Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPbeta) stability and accelerates adipogenesis and lipid accumulation. | Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation.
Kim MS, Baek JH, Lee J, Sivaraman A, Lee K, Chun KH., Free PMC Article | 12/1/2023 |
| USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m[6]A Modification of YAP1 mRNA. | USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and Improves Functional Recovery after Spinal Cord Injury through m(6)A Modification of YAP1 mRNA.
Ge X, Ye W, Zhu Y, Cui M, Zhou J, Xiao C, Jiang D, Tang P, Wang J, Wang Z, Ji C, Zhou X, Cao X, Liu W, Cai W., Free PMC Article | 03/7/2023 |
| The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion. | The promotive role of USP1 inhibition in coordinating osteogenic differentiation and fracture healing during nonunion.
Huang J, Zhou H, He L, Zhong L, Zhou D, Yin Z., Free PMC Article | 03/7/2023 |
| Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity. | Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity.
Omilusik KD, Nadjsombati MS, Yoshida TM, Shaw LA, Goulding J, Goldrath AW., Free PMC Article | 09/11/2021 |
| USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation. | USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.
Goldbraikh D, Neufeld D, Eid-Mutlak Y, Lasry I, Gilda JE, Parnis A, Cohen S., Free PMC Article | 05/8/2021 |
| our results strongly suggest that Usp1 is involved in the regulation of centrosome duplication, at least in part via ID1, and Usp1 may exert its oncogenic activity, partially through inducing centrosome abnormality. | A novel role for the deubiquitinase USP1 in the control of centrosome duplication.
Jung JK, Jang SW, Kim JM., Free PMC Article | 12/17/2016 |
| Data suggest Usp1 down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 (Fanconi anemia complementation group D2) and Pcna (proliferating cell nuclear antigen). | The role of USP1 autocleavage in DNA interstrand crosslink repair.
Kim M, Kim JM. | 06/28/2016 |
| Homozygous Uaf1(-/-) embryos died at embryonic day 7.5 (E7.5). These mutant embryos were small and developmentally retarded. | Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice.
Park E, Kim JM, Primack B, Weinstock DM, Moreau LA, Parmar K, D'Andrea AD., Free PMC Article | 12/28/2013 |
| Autocleaved Usp1 remains a deubiquitylase because its fragments remain associated with Uaf1, an enhancer of Usp1 activity, until the C-terminal fragment is selectively destroyed by the Arg/N-end rule pathway. | The auto-generated fragment of the Usp1 deubiquitylase is a physiological substrate of the N-end rule pathway.
Piatkov KI, Colnaghi L, Békés M, Varshavsky A, Huang TT., Free PMC Article | 02/23/2013 |
| Bone marrow from Fancd2-/- mice and Usp1-/- mice exhibited marked hematopoietic defects. | Hematopoietic stem cell defects in mice with deficiency of Fancd2 or Usp1.
Parmar K, Kim J, Sykes SM, Shimamura A, Stuckert P, Zhu K, Hamilton A, Deloach MK, Kutok JL, Akashi K, Gilliland DG, D'andrea A., Free PMC Article | 11/13/2010 |
| mouse Usp1 functions downstream in the Fanconi anemia pathway, and its deubiquitination is required for Fancd2 nuclear foci assembly | Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype.
Kim JM, Parmar K, Huang M, Weinstock DM, Ruit CA, Kutok JL, D'Andrea AD., Free PMC Article | 01/21/2010 |