| [PDS5B inhibits the proliferation of A549 human lung cancer cells via downregulation of Wnt5a]. | [PDS5B inhibits the proliferation of A549 human lung cancer cells via downregulation of Wnt5a].
Ma L, Ma T, Zhou W, Li J, Li Y, Xu H. | 02/9/2023 |
| PDS5A and PDS5B in Cohesin Function and Human Disease. | PDS5A and PDS5B in Cohesin Function and Human Disease.
Zhang N, Coutinho LE, Pati D., Free PMC Article | 06/26/2021 |
| PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection. | PDS5 proteins are required for proper cohesin dynamics and participate in replication fork protection.
Morales C, Ruiz-Torres M, Rodríguez-Acebes S, Lafarga V, Rodríguez-Corsino M, Megías D, Cisneros DA, Peters JM, Méndez J, Losada A., Free PMC Article | 09/12/2020 |
| Pds5b/Ptch2 axis regulates cell proliferation and invasion in pancreatic tumor cells. | PDS5B regulates cell proliferation and motility via upregulation of Ptch2 in pancreatic cancer cells.
Ma J, Cui Y, Cao T, Xu H, Shi Y, Xia J, Tao Y, Wang ZP. | 05/30/2020 |
| our study uncovers a protein complex, which consists of SWS1, SWSAP1, SPIDR and PDS5B, involved in DNA repair and provides insight into Shu complex function and composition. | The human Shu complex functions with PDS5B and SPIDR to promote homologous recombination.
Martino J, Brunette GJ, Barroso-González J, Moiseeva TN, Smith CM, Bakkenist CJ, O'Sullivan RJ, Bernstein KA., Free PMC Article | 12/14/2019 |
| Pds5B forms an integral part of the cohesin ring by contacting all other cohesin subunits, a property that may reflect the complex role of Pds5 proteins in controlling cohesin-DNA interactions. | Topology and structure of an engineered human cohesin complex bound to Pds5B.
Hons MT, Huis In 't Veld PJ, Kaesler J, Rombaut P, Schleiffer A, Herzog F, Stark H, Peters JM., Free PMC Article | 09/8/2018 |
| MAGI2-AS3 plays an important role as a tumour suppressor by targeting Fas and FasL signalling. | Long non-coding RNA (lncRNA) MAGI2-AS3 inhibits breast cancer cell growth by targeting the Fas/FasL signalling pathway.
Yang Y, Yang H, Xu M, Zhang H, Sun M, Mu P, Dong T, Du S, Liu K. | 08/11/2018 |
| The authors' data identify the HIM of Pds5 as a binding motif for Haspin/Hrk1 in fission yeast. The authors' analyses also show that human PDS5B binds Haspin through the same HIM-PIM interaction module, indicating that the Haspin localization mechanism is highly conserved. | Pds5 Regulates Sister-Chromatid Cohesion and Chromosome Bi-orientation through a Conserved Protein Interaction Module.
Goto Y, Yamagishi Y, Shintomi-Kawamura M, Abe M, Tanno Y, Watanabe Y. | 07/14/2018 |
| The mitotic histone kinase Haspin binds to the cohesin regulatory subunit Pds5B through a conserved YGA/R motif in its non-catalytic N terminus, which is similar to the recently reported YSR-motif-dependent binding of Wapl to Pds5B. | The N-Terminal Non-Kinase-Domain-Mediated Binding of Haspin to Pds5B Protects Centromeric Cohesion in Mitosis.
Zhou L, Liang C, Chen Q, Zhang Z, Zhang B, Yan H, Qi F, Zhang M, Yi Q, Guan Y, Xiang X, Zhang X, Ye S, Wang F. | 07/14/2018 |
| The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL. | Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.
Wutz G, Várnai C, Nagasaka K, Cisneros DA, Stocsits RR, Tang W, Schoenfelder S, Jessberger G, Muhar M, Hossain MJ, Walther N, Koch B, Kueblbeck M, Ellenberg J, Zuber J, Fraser P, Peters JM., Free PMC Article | 12/30/2017 |
| Pds5 stabilizes a transient, open state of cohesin to promote its release from chromosomes. | Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics.
Ouyang Z, Zheng G, Tomchick DR, Luo X, Yu H., Free PMC Article | 08/5/2017 |
| APRIN expression levels correlate with a better survival in ovarian cancer patients and that APRIN depletion sensitizes cells to the PARP inhibitor Olaparib in xenografted zebrafish. | Roles for APRIN (PDS5B) in homologous recombination and in ovarian cancer prediction.
Couturier AM, Fleury H, Patenaude AM, Bentley VL, Rodrigue A, Coulombe Y, Niraj J, Pauty J, Berman JN, Dellaire G, Di Noia JM, Mes-Masson AM, Masson JY., Free PMC Article | 06/24/2017 |
| Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. | Frameshift mutations of chromosome cohesion-related genes SGOL1 and PDS5B in gastric and colorectal cancers with high microsatellite instability.
Kim MS, An CH, Yoo NJ, Lee SH. | 11/23/2013 |
| Here, the authors use proteomic profiling to identify APRIN (PDS5B), a cohesion-associated protein, as a BRCA2-associated protein. | APRIN is a cell cycle specific BRCA2-interacting protein required for genome integrity and a predictor of outcome after chemotherapy in breast cancer.
Brough R, Bajrami I, Vatcheva R, Natrajan R, Reis-Filho JS, Lord CJ, Ashworth A., Free PMC Article | 05/5/2012 |
| Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma. | Loss of a cohesin-linked suppressor APRIN (Pds5b) disrupts stem cell programs in embryonal carcinoma: an emerging cohesin role in tumor suppression.
Denes V, Pilichowska M, Makarovskiy A, Carpinito G, Geck P. | 06/28/2010 |
| Pard-3 and AS3 genes are mutationally inactivated in prostate cancer cells. | Par-3 partitioning defective 3 homolog (C. elegans) and androgen-induced prostate proliferative shutoff associated protein genes are mutationally inactivated in prostate cancer cells.
Kunnev D, Ivanov I, Ionov Y., Free PMC Article | 01/21/2010 |
| identified a functional missense mutation (R1292Q) in the PDS5B DNA-binding domain in a family with Cornelia de Lange syndrome, in which affected individuals also develop megacolon | Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, Krantz I, Milbrandt J., Free PMC Article | 01/21/2010 |
| The results of this study indicate that the aberrant expression of AS3 may be involved in the tumorigenesis of esophagus and is responsible for the male predominance of ESCC. | Correlation of genomic and expression alterations of AS3 with esophageal squamous cell carcinoma.
Zhang Y, Huang X, Qi J, Yan C, Xu X, Han Y, Wang M. | 01/21/2010 |
| AS3 is a mediator of the proliferative arrest in the normal rat prostate in situ and that its expression is androgen-induced (AS3 protein) | Mechanism of androgen action on cell proliferation: AS3 protein as a mediator of proliferative arrest in the rat prostate.
Maffini MV, Geck P, Powell CE, Sonnenschein C, Soto AM. | 01/21/2010 |