| The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis. | The Role of SCAP/SREBP as Central Regulators of Lipid Metabolism in Hepatic Steatosis.
Chandrasekaran P, Weiskirchen R., Free PMC Article | 02/28/2024 |
| SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway. | SARS-CoV-2 nucleocapsid protein promotes TMAO-induced NLRP3 inflammasome activation by SCAP-SREBP signaling pathway.
Liu MH, Lin XL, Xiao LL. | 01/26/2024 |
| Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway. | Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway.
Makokha GN, Chayama K, Hayes CN, Abe-Chayama H, Abuduwaili M, Hijikata M. | 07/25/2023 |
| Structural basis for sterol sensing by Scap and Insig. | Structural basis for sterol sensing by Scap and Insig.
Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N. | 02/12/2022 |
| Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. | Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X., Free PMC Article | 01/15/2022 |
| PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability. | PKM2-TMEM33 axis regulates lipid homeostasis in cancer cells by controlling SCAP stability.
Liu F, Ma M, Gao A, Ma F, Ma G, Liu P, Jia C, Wang Y, Donahue K, Zhang S, Ong IM, Keles S, Li L, Xu W., Free PMC Article | 01/8/2022 |
| The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites. | The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites.
Wakana Y, Hayashi K, Nemoto T, Watanabe C, Taoka M, Angulo-Capel J, Garcia-Parajo MF, Kumata H, Umemura T, Inoue H, Arasaki K, Campelo F, Tagaya M., Free PMC Article | 05/22/2021 |
| A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols. | A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.
Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N. | 04/3/2021 |
| Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP. | Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP.
Kuan YC, Takahashi Y, Maruyama T, Shimizu M, Yamauchi Y, Sato R., Free PMC Article | 12/12/2020 |
| Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children. | Interaction between lifestyle behaviors and genetic polymorphism in SCAP gene on blood pressure among Chinese children.
Yang YD, Song JY, Wang S, Wang Y, Song QY, Li CX, Dong B, Wang HJ, Ma J. | 08/22/2020 |
| cholesterol inhibited the progression of HCC through restraining SCAP-mediated fatty acid de novo synthesis. | Cholesterol attenuated the progression of DEN-induced hepatocellular carcinoma via inhibiting SCAP mediated fatty acid de novo synthesis.
Zhao Z, Zhong L, He K, Qiu C, Li Z, Zhao L, Gong J. | 11/9/2019 |
| GP73 is indispensable for SREBPs activation and lipogenesis. Notably, GP73 overexpression enhanced SCAP-SREBP1 binding and its Golgi trafficking even under cholesterol sufficiency. | GP73 regulates Hepatic Steatosis by enhancing SCAP-SREBPs interaction.
Yang X, Wu F, Chen J, Wang C, Zhu Y, Li F, Hao Q, Duan C, Wang L, Ma X, Zou D, Luo L, Zhao Y, Guan K, Cao Y, Zhang P, Zhou P, Ma S, Yan Z, Li J, Zhang Y, Wei C, Zhong H., Free PMC Article | 07/20/2019 |
| Our study reveals that, in addition to controlling cholesterol biosynthesis, SCAP-SREBP2 also serves as a signaling hub integrating cholesterol metabolism with inflammation in macrophages. | Cholesterol Homeostatic Regulator SCAP-SREBP2 Integrates NLRP3 Inflammasome Activation and Cholesterol Biosynthetic Signaling in Macrophages.
Guo C, Chi Z, Jiang D, Xu T, Yu W, Wang Z, Chen S, Zhang L, Liu Q, Guo X, Zhang X, Li W, Lu L, Wu Y, Song BL, Wang D. | 04/27/2019 |
| Polymorphism in SCAP gene is associated with high blood pressure. | Genetic variations in sterol regulatory element binding protein cleavage-activating protein (SCAP) are associated with blood pressure in overweight/obese Chinese children.
Yang YD, Song JY, Wang S, Liu FH, Zhang YN, Shang XR, Wang HJ, Ma J., Free PMC Article | 10/7/2017 |
| These insights suggest a new structural model for cholesterol-mediated regulation of Scap activity. | Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis.
Gao Y, Zhou Y, Goldstein JL, Brown MS, Radhakrishnan A., Free PMC Article | 06/10/2017 |
| The genetic polymorphisms of SREBF1 could play a role in the mechanism for interindividual variation of atypical antipsychotics-induced metabolic syndrome (MetS). SCAP polymorphisms with drug-induced MetS were negative in this study. | Association between SCAP and SREBF1 gene polymorphisms and metabolic syndrome in schizophrenia patients treated with atypical antipsychotics.
Yang L, Chen J, Li Y, Wang Y, Liang S, Shi Y, Shi S, Xu Y. | 05/27/2017 |
| this study uncovered a novel function of SCAP of counteracting the inhibitory action of Dengue Virus NS2B3 protease on STING signaling, suggesting that modulation of SCAP levels may have therapeutic implications. | Endoplasmic Reticulum Protein SCAP Inhibits Dengue Virus NS2B3 Protease by Suppressing Its K27-Linked Polyubiquitylation.
Liu H, Zhang L, Sun J, Chen W, Li S, Wang Q, Yu H, Xia Z, Jin X, Wang C., Free PMC Article | 05/20/2017 |
| Data indicate that glucose-mediated glycosylation promotes SREBP cleavage-activating protein (SCAP) trafficking to the Golgi Leading to sterol regulatory element binding protein 1 (SREBP-1) activation. | Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.
Cheng C, Ru P, Geng F, Liu J, Yoo JY, Wu X, Cheng X, Euthine V, Hu P, Guo JY, Lefai E, Kaur B, Nohturfft A, Ma J, Chakravarti A, Guo D., Free PMC Article | 04/9/2016 |
| identified interaction of three genes in INSIG-SCAP-SREBP pathway on risk of obesity, revealing that these genes affect obesity more likely through a complex interaction pattern than single gene effect. | The gene-gene interaction of INSIG-SCAP-SREBP pathway on the risk of obesity in Chinese children.
Liu FH, Song JY, Shang XR, Meng XR, Ma J, Wang HJ., Free PMC Article | 03/21/2015 |
| Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation. | Enhanced SCAP glycosylation by inflammation induces macrophage foam cell formation.
Zhou C, Lei H, Chen Y, Liu Q, Li LC, Moorhead JF, Varghese Z, Ruan XZ., Free PMC Article | 07/26/2014 |
| SCAP gene polymorphisms decrease the risk of nonalcoholic fatty liver disease in females with metabolic syndrome. | SCAP gene polymorphisms decrease the risk of nonalcoholic fatty liver disease in females with metabolic syndrome.
Sun S, Wang M, Song H, Wu T, Wei H, He S, Ding Z, Ji G. | 06/28/2014 |
| SREBP cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP) | Sterol regulatory element-binding protein (SREBP) cleavage regulates Golgi-to-endoplasmic reticulum recycling of SREBP cleavage-activating protein (SCAP).
Shao W, Espenshade PJ., Free PMC Article | 05/17/2014 |
| A point mutation in Scap Loop 7 prevents interaction with Loop 1 and abolishes endoplasmic reticulum exit. | Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi.
Zhang Y, Motamed M, Seemann J, Brown MS, Goldstein JL., Free PMC Article | 08/10/2013 |
| the SCAP/SREBP signaling axis has a role in protecting cancer cells from lipotoxicity | An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.
Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ., Free PMC Article | 06/29/2013 |
| Data indicate that SREBP-2 and Scap are regulated by factors driving prostate growth, and suggest exploring this observation further could shed light on prostate carcinogenesis. | Overexpression of a key regulator of lipid homeostasis, Scap, promotes respiration in prostate cancer cells.
Prabhu AV, Krycer JR, Brown AJ. | 05/25/2013 |