| Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction. | Vasohibin inhibition improves myocardial relaxation in a rat model of heart failure with preserved ejection fraction.
Eaton DM, Lee BW, Caporizzo MA, Iyengar A, Chen CY, Uchida K, Marcellin G, Lannay Y, Vite A, Bedi KC Jr, Brady CF, Smolyak JN, Meldrum D, Dominic J, Weingarten N, Patel M, Belec A, Hached K, Atluri P, Van Der Laan S, Prosser BL, Margulies KB. | 08/16/2024 |
| m[6]A methylation-mediated regulation of LncRNA MEG3 suppresses ovarian cancer progression through miR-885-5p and the VASH1 pathway. | m(6)A methylation-mediated regulation of LncRNA MEG3 suppresses ovarian cancer progression through miR-885-5p and the VASH1 pathway.
Li Y, Lou S, Zhang J, Zhao S, Lou G., Free PMC Article | 02/29/2024 |
| Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives. | Revealing the inhibitory effect of VASH1 on ovarian cancer from multiple perspectives.
Li Y, Meng L, Lou G., Free PMC Article | 12/5/2023 |
| Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer. | Mechanism of ELL-associated factor 2 and vasohibin 1 regulating invasion, migration, and angiogenesis in colorectal cancer.
Feng ML, Sun MJ, Xu BY, Liu MY, Zhang HJ, Wu C., Free PMC Article | 10/20/2023 |
| ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway. | ZNF667 facilitates angiogenesis after myocardial ischemia through transcriptional regulation of VASH1 and Wnt signaling pathway.
Wang W, Shang W, Zou J, Liu K, Liu M, Qiu X, Zhang H, Wang K, Wang N., Free PMC Article | 09/3/2022 |
| Serum levels of vasohibin-1 in type 2 diabetes mellitus patients with diabetic retinopathy. | Serum levels of vasohibin-1 in type 2 diabetes mellitus patients with diabetic retinopathy.
Feng Y, Wang D, Liu Y, Pang X, Zhang H. | 08/20/2022 |
| Significance of vasohibin 1 in cancer patients: A systematic review and meta analysis. | Significance of vasohibin 1 in cancer patients: A systematic review and meta analysis.
Liu S, Han B, Sun M, Wang J, Sun Y, Wang Y. | 06/11/2022 |
| Vasohibin-1 and -2 in pulmonary lymphangioleiomyomatosis (LAM) cells associated with angiogenic and prognostic factors. | Vasohibin-1 and -2 in pulmonary lymphangioleiomyomatosis (LAM) cells associated with angiogenic and prognostic factors.
Inoue C, Miki Y, Saito-Koyama R, Kobayashi K, Seyama K, Okada Y, Sasano H. | 03/26/2022 |
| Vasohibin-1 expression as a biomarker of aggressive nature in ductal adenocarcinoma of the prostate: a retrospective cohort study at two centres in Japan. | Vasohibin-1 expression as a biomarker of aggressive nature in ductal adenocarcinoma of the prostate: a retrospective cohort study at two centres in Japan.
Kobayashi H, Kosaka T, Mikami S, Kimura T, Hongo H, Kosugi M, Sato Y, Oya M., Free PMC Article | 12/11/2021 |
| Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors. | Tubulin carboxypeptidase activity of vasohibin-1 inhibits angiogenesis by interfering with endocytosis and trafficking of pro-angiogenic factor receptors.
Kobayashi M, Wakabayashi I, Suzuki Y, Fujiwara K, Nakayama M, Watabe T, Sato Y. | 10/30/2021 |
| Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes. | Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.
Chen CY, Salomon AK, Caporizzo MA, Curry S, Kelly NA, Bedi K, Bogush AI, Krämer E, Schlossarek S, Janiak P, Moutin MJ, Carrier L, Margulies KB, Prosser BL., Free PMC Article | 05/22/2021 |
| Vasohibin 1, a clinically relevant biomarker, contributes to pre-eclampsia. | Vasohibin 1, a clinically relevant biomarker, contributes to pre-eclampsia.
Liang Y, Wang F, Chen G, Lu W, Zhang Y. | 05/1/2021 |
| VEZF1-guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1. | VEZF1-guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1.
Li L, Williams P, Gao Z, Wang Y., Free PMC Article | 12/26/2020 |
| Prognostic significance of vasohibin-1 and vasohibin-2 immunohistochemical expression in gastric cancer. | Prognostic significance of vasohibin-1 and vasohibin-2 immunohistochemical expression in gastric cancer.
Hara H, Ozawa S, Ninomiya Y, Yamamoto M, Ogimi M, Nabeshima K, Nakamura K, Kajiwara H, Nakamura N, Sato Y. | 11/28/2020 |
| Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis. | Vasoinhibin reduces joint inflammation, bone loss, and the angiogenesis and vasopermeability of the pannus in murine antigen-induced arthritis.
Ortiz G, Ledesma-Colunga MG, Wu Z, García-Rodrigo JF, Adan N, Martínez de la Escalera G, Clapp C. | 11/21/2020 |
| The authors identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1) that catalyzes the detyrosination of a peptide derived from C-terminus of alpha-tubulin. | Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis.
Liao S, Rajendraprasad G, Wang N, Eibes S, Gao J, Yu H, Wu G, Tu X, Huang H, Barisic M, Xu C., Free PMC Article | 09/12/2020 |
| Vasoinhibin downregulates NGF-induced differentiation and survival of PC12 cells. Vasoinhibin interaction with NGF and other neurotrophins may be critical in mediating pathways involved in neuronal survival and differentiation. | Vasoinhibin Suppresses Nerve Growth Factor-Induced Differentiation and Survival of PC12 Pheochromocytoma Cells.
Melo Z, Castillo X, Moreno-Carranza B, Ledesma-Colunga MG, Arnold E, López-Casillas F, Ruíz-Herrera X, Clapp C, Martínez de la Escalera G. | 06/6/2020 |
| This study examined the crystal structures of human vasohibin 1 and 2 in complex with small vasohibin-binding protein (SVBP) in the absence and presence of different inhibitors and a C-terminal alpha-tubulin peptide. | Structural basis of tubulin detyrosination by the vasohibin-SVBP enzyme complex.
Wang N, Bosc C, Ryul Choi S, Boulan B, Peris L, Olieric N, Bao H, Krichen F, Chen L, Andrieux A, Olieric V, Moutin MJ, Steinmetz MO, Huang H. | 02/29/2020 |
| This study reports the crystal structures of human VASH1-SVBP alone, in complex with a tyrosine-derived covalent inhibitor and bound to the natural product parthenolide. | Structural basis of tubulin detyrosination by vasohibins.
Li F, Hu Y, Qi S, Luo X, Yu H., Free PMC Article | 02/29/2020 |
| This study describes the crystal and solution structure of the tubulin carboxypeptidase complex between vasohibin (VASH1) and small vasohibin-binding protein (SVBP), which folds in a long helix, which stabilizes the VASH1 catalytic domain. | Crystal structure of the tubulin tyrosine carboxypeptidase complex VASH1-SVBP.
Adamopoulos A, Landskron L, Heidebrecht T, Tsakou F, Bleijerveld OB, Altelaar M, Nieuwenhuis J, Celie PHN, Brummelkamp TR, Perrakis A. | 02/29/2020 |
| The vasohibin1 was identified as the first tubulin-detyrosinating enzyme, A cell-autonomous role for vasohibin1 in regulating the cytoskeleton was unexpected due to their previous association with angiogenesis. | The Tubulin Detyrosination Cycle: Function and Enzymes.
Nieuwenhuis J, Brummelkamp TR. | 06/22/2019 |
| In conclusion, cervical squamous cell carcinoma (CSCC)-secreted exosomal miR-221-3p transfers into HLECs to promote lymphangiogenesis and lymphatic metastasis via downregulation of VASH1 and may represent a novel diagnostic biomarker and therapeutic target for metastatic CSCC patients in early stages | Cervical squamous cell carcinoma-secreted exosomal miR-221-3p promotes lymphangiogenesis and lymphatic metastasis by targeting VASH1.
Zhou CF, Ma J, Huang L, Yi HY, Zhang YM, Wu XG, Yan RM, Liang L, Zhong M, Yu YH, Wu S, Wang W., Free PMC Article | 03/9/2019 |
| We applied whole-genome sequencing (WGS) on 9 trios where the probands are sporadically affected with the most severe form of the disorder and harbor no coding sequence variants affecting the function of known Hirschsprung disease (HSCR) genes. We found de novo protein-altering variants in three intolerant to change genes-CCT2, VASH1, and CYP26A1-for which a plausible link with the enteric nervous system (ENS) exists | Uncovering the genetic lesions underlying the most severe form of Hirschsprung disease by whole-genome sequencing.
Tang CS, Zhuang X, Lam WY, Ngan ES, Hsu JS, Michelle YU, Man-Ting SO, Cherny SS, Ngo ND, Sham PC, Tam PK, Garcia-Barcelo MM., Free PMC Article | 02/23/2019 |
| Low VASH1 expression is associated with angiogenesis and tumor growth in renal cell carcinoma. | Vasohibin-1 inhibits angiogenesis and suppresses tumor growth in renal cell carcinoma.
Zhao G, Na R, Li L, Xiao H, Ding N, Sun Y, Han R. | 07/28/2018 |
| VASH1 is a prognostic marker in ovarian carcinoma. | Vasohibin-1 Is a Poor Prognostic Factor of Ovarian Carcinoma.
Sano R, Kanomata N, Suzuki S, Shimoya K, Sato Y, Moriya T, Shiota M. | 06/23/2018 |