| Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors. | Finely ordered intracellular domain harbors an allosteric site to modulate physiopathological function of P2X3 receptors.
Lin YY, Lu Y, Li CY, Ma XF, Shao MQ, Gao YH, Zhang YQ, Jiang HN, Liu Y, Yang Y, Huang LD, Cao P, Wang HS, Wang J, Yu Y., Free PMC Article | 10/11/2024 |
| The purinergic receptors 2X3 on spiral ganglion neurons enhance the medial olivocochlear reflex in mice after long-term moderate noise exposure. | The purinergic receptors 2X3 on spiral ganglion neurons enhance the medial olivocochlear reflex in mice after long-term moderate noise exposure.
Yin D, Zhang T, Dai P. | 11/19/2022 |
| Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge. | Involvement of P2X2 receptor in the medial prefrontal cortex in ATP modulation of the passive coping response to behavioral challenge.
Kong Y, Wang Q, Wu DY, Hu J, Zang WS, Li XW, Yang JM, Gao TM. | 08/21/2021 |
| The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development. | The Purinergic Receptor P2rx3 is Required for Spiral Ganglion Neuron Branch Refinement during Development.
Wang Z, Jung JS, Inbar TC, Rangoussis KM, Faaborg-Andersen C, Coate TM., Free PMC Article | 06/26/2021 |
| Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing. | Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing.
Lu R, Metzner K, Zhou F, Flauaus C, Balzulat A, Engel P, Petersen J, Ehinger R, Bausch A, Ruth P, Lukowski R, Schmidtko A., Free PMC Article | 04/17/2021 |
| This study demonstrated that the P2X3-immunoreactive nerve endings in the rat tracheal mucosa have unique morphological characteristics, and these endings may be rapidly adapting receptors and/or irritant receptors that are activated by mucosal irritant stimuli. | Morphology of P2X3-immunoreactive nerve endings in the rat tracheal mucosa.
Yamamoto Y, Nakamuta N. | 07/28/2018 |
| Data suggest that the negative inhibition of P2X3R activity by the BNP/NPR-A pathway results in a decreased P2X3R-mediated excitability of trigeminal neurons in wildetype cultures. In familial hemiplegic migraine type-1 model cultures, however, lack of efficient P2X3Rs downregulation contributes to the neuronal hyperexcitability phenotype. | Loss of inhibition by brain natriuretic peptide over P2X3 receptors contributes to enhanced spike firing of trigeminal ganglion neurons in a mouse model of familial hemiplegic migraine type-1.
Marchenkova A, van den Maagdenberg AM, Nistri A. | 07/15/2017 |
| P2X3 receptors on mouse trigeminal ganglion neurons are subjected to contrasting modulation by inhibitory brain natriuretic peptide and facilitatory calcitonin gene-related peptide that both operate via complex intracellular signaling. | Inefficient constitutive inhibition of P2X3 receptors by brain natriuretic peptide system contributes to sensitization of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine.
Marchenkova A, Vilotti S, Ntamati N, van den Maagdenberg AM, Nistri A., Free PMC Article | 12/31/2016 |
| mouse trigeminal neurons endogenous BNP acts on NPR-A receptors to determine constitutive depression of P2X3 receptor function. Tonic inhibition of P2X3 receptor activity by BNP/NPR-A/PKG pathways occurs via two distinct mechanisms: P2X3 serine phosphorylation and receptor redistribution to non-raft membrane compartments | Brain natriuretic peptide constitutively downregulates P2X3 receptors by controlling their phosphorylation state and membrane localization.
Marchenkova A, Vilotti S, Fabbretti E, Nistri A., Free PMC Article | 09/24/2016 |
| may be involved in skeletal pain due to high bone turnover | Acid-sensing ion channel 3 or P2X2/3 is involved in the pain-like behavior under a high bone turnover state in ovariectomized mice.
Kanaya K, Iba K, Abe Y, Dohke T, Okazaki S, Matsumura T, Yamashita T. | 08/20/2016 |
| This study observed maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice. | Maltodextrin and fat preference deficits in "taste-blind" P2X2/P2X3 knockout mice.
Sclafani A, Ackroff K., Free PMC Article | 02/7/2015 |
| a slow modulatory action by BNP on TRPV1 and P2X3 receptors outlining the role of this peptide as a negative regulator of trigeminal sensory neuron excitability to nociceptive stimuli | B-type natriuretic peptide-induced delayed modulation of TRPV1 and P2X3 receptors of mouse trigeminal sensory neurons.
Vilotti S, Marchenkova A, Ntamati N, Nistri A., Free PMC Article | 12/20/2014 |
| P2X(3)R overexpression may underlie ectopic mechanical allodynia in the whisker pad skin | P2X3 receptor mediates ectopic mechanical allodynia with inflamed lower lip in mice.
Yasuda M, Shinoda M, Kiyomoto M, Honda K, Suzuki A, Tamagawa T, Kaji K, Kimoto S, Iwata K. | 05/3/2014 |
| genetic manipulation of TRPV1 and P2X3 leads to reduction in colorectal mechanosensation peripherally and compensatory changes and/or disinhibition of other channels centrally. | Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization.
Kiyatkin ME, Feng B, Schwartz ES, Gebhart GF., Free PMC Article | 02/15/2014 |
| up-regulation of P2X3 receptors probably is already maximal and is apparently contributed by basal CGRP and BDNF levels | The mechanism of functional up-regulation of P2X3 receptors of trigeminal sensory neurons in a genetic mouse model of familial hemiplegic migraine type 1 (FHM-1).
Hullugundi SK, Ferrari MD, van den Maagdenberg AM, Nistri A., Free PMC Article | 10/26/2013 |
| Structure and function of P2RX3 is reviewed, and its role in treatment of pain is discussed. [Review Article] | Regulation of P2X3 receptor structure and function.
Fabbretti E, Nistri A. | 06/8/2013 |
| interaction between P2X3/TRPV1 and ERs expression in sensory neurons may represent a novel mechanism that can explain the sex differences in nociception observed in clinical practice. | Expression of P2X3 and TRPV1 receptors in primary sensory neurons from estrogen receptors-α and estrogen receptor-β knockout mice.
Cho T, Chaban VV., Free PMC Article | 10/20/2012 |
| An interaction between P2X3 and membrane-associated ERalpha in primary sensory neurones that may represent a novel mechanism to explain sex differences observed in the clinical presentation of visceral nociceptive syndromes. | Interaction between P2X3 and oestrogen receptor (ER)α/ERβ in ATP-mediated calcium signalling in mice sensory neurones.
Cho T, Chaban VV., Free PMC Article | 07/14/2012 |
| Transcripts for P2X3 were present in nearly all colon neurons examined. About half of the cells only containing P2X3 transcripts, and zymosan did not change this. The fast current triggered by ATP and alpha,beta-meATP is dependent on P2X3 receptors. | Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity.
Shinoda M, La JH, Bielefeldt K, Gebhart GF., Free PMC Article | 05/14/2011 |
| CACNA1A mutation conferred a novel molecular phenotype to P2X3 receptors of trigeminal ganglion neurons via CaMKII-dependent activation of calcineurin. | Familial hemiplegic migraine Ca(v)2.1 channel mutation R192Q enhances ATP-gated P2X3 receptor activity of mouse sensory ganglion neurons mediating trigeminal pain.
Nair A, Simonetti M, Birsa N, Ferrari MD, van den Maagdenberg AM, Giniatullin R, Nistri A, Fabbretti E., Free PMC Article | 01/8/2011 |
| chronic esophagitis results in upregulation of P2X(3) and its co-localization with TRPV1 receptor in vagal and spinal afferents. | Altered expression of P2X3 in vagal and spinal afferents following esophagitis in rats.
Banerjee B, Medda BK, Schmidt J, Zheng Y, Zhang Z, Shaker R, Sengupta JN., Free PMC Article | 04/19/2010 |
| In brief access tests, double P2X2/P2X3 purinergic receptor null mice avoided citric acid and hydrochloric acid at the same concentrations as their wild-type counterparts, indicating that these weak acids activate oropharyngeal chemoreceptors. | Residual chemosensory capabilities in double P2X2/P2X3 purinergic receptor null mice: intraoral or postingestive detection?
Hallock RM, Tatangelo M, Barrows J, Finger TE., Free PMC Article | 02/1/2010 |
| Data suggest that double P2X2/P2X3 purinergic receptor knockout mice are unable to respond to NaCl or the artificial sweetener SC45647 as taste stimuli, mirroring the lack of gustatory nerve responses to these substances. | Double P2X2/P2X3 purinergic receptor knockout mice do not taste NaCl or the artificial sweetener SC45647.
Eddy MC, Eschle BK, Barrows J, Hallock RM, Finger TE, Delay ER., Free PMC Article | 02/1/2010 |
| This synergism opens the theoretical possibility that the combination of both types of drugs could be useful to counteract some nociceptive symptoms derived from tumor development. | Involvement of enkephalins in the inhibition of osteosarcoma-induced thermal hyperalgesia evoked by the blockade of peripheral P2X3 receptors.
González-Rodríguez S, Pevida M, Roques BP, Fournié-Zaluski MC, Hidalgo A, Menéndez L, Baamonde A. | 01/21/2010 |
| Results suggest differential roles for peripheral and central P2X(3) receptors in colon mechanosensory transduction and hypersensitivity. | Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse.
Shinoda M, Feng B, Gebhart GF., Free PMC Article | 01/21/2010 |