| Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay. | Dominant negative variants in IKZF2 cause ICHAD syndrome, a new disorder characterised by immunodysregulation, craniofacial anomalies, hearing impairment, athelia and developmental delay.
Mohajeri A, Vaseghi-Shanjani M, Rosenfeld JA, Yang GX, Lu H, Sharma M, Lin S, Salman A, Waqas M, Sababi Azamian M, Worley KC, Del Bel KL, Kozak FK, Rahmanian R, Biggs CM, Hildebrand KJ, Lalani SR, Nicholas SK, Scott DA, Mostafavi S, van Karnebeek C, Henkelman E, Halparin J, Yang CL, Armstrong L, Undiagnosed Diseases Network, Care4Rare Canada Consortium, Turvey SE, Lehman A., Free PMC Article | 01/31/2024 |
| Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case-control study. | Temporal changes in regulatory T cell subsets defined by the transcription factor Helios in stroke and their potential role in stroke-associated infection: a prospective case-control study.
Lukasik M, Telec M, Kazmierski R, Wojtasz I, Andrzejewska-Gorczyńska N, Kociemba W, Dworacki G, Kozubski WP, Frydrychowicz M., Free PMC Article | 11/28/2023 |
| Decreased frequency of regulatory T cells and level of helios gene expression in secondary progressive multiple sclerosis patients: Evidence about the development of multiple sclerosis. | Decreased frequency of regulatory T cells and level of helios gene expression in secondary progressive multiple sclerosis patients: Evidence about the development of multiple sclerosis.
Tarighi M, Shahbazi M, Saadat P, Daraei A, Alizadeh Khatir A, Rahimifard K, Mohammadnia-Afrouzi M. | 03/11/2023 |
| Aging-associated HELIOS deficiency in naive CD4[+] T cells alters chromatin remodeling and promotes effector cell responses. | Aging-associated HELIOS deficiency in naive CD4(+) T cells alters chromatin remodeling and promotes effector cell responses.
Zhang H, Jadhav RR, Cao W, Goronzy IN, Zhao TV, Jin J, Ohtsuki S, Hu Z, Morales J, Greenleaf WJ, Weyand CM, Goronzy JJ., Free PMC Article | 01/14/2023 |
| Expression of Programmed Cell Death 1 and Helios Genes Correlates With rs872071A>G and rs12203592C>T Single-Nucleotide Polymorphisms of InterferonRegulatory Factor 4 in Patients with T-Cell-Mediated Rejection of Renal Allograft. | Expression of Programmed Cell Death 1 and Helios Genes Correlates With rs872071A>G and rs12203592C>T Single-Nucleotide Polymorphisms of InterferonRegulatory Factor 4 in Patients with T-Cell-Mediated Rejection of Renal Allograft.
Alamdari A, Minoo FS, Assadiasl S, Freidoon M, Pour-Reza-Gholi F, Soleimanifar N, Mohebbi B, Sadr M, Lesan Pezeshki M, Nicknam MH. | 06/18/2022 |
| Co-Expression of TIGIT and Helios Marks Immunosenescent CD8(+) T Cells During Aging. | Co-Expression of TIGIT and Helios Marks Immunosenescent CD8(+) T Cells During Aging.
Pieren DKJ, Smits NAM, Postel RJ, Kandiah V, de Wit J, van Beek J, van Baarle D, Guichelaar T., Free PMC Article | 06/11/2022 |
| Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation. | Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation.
Shahin T, Mayr D, Shoeb MR, Kuehn HS, Hoeger B, Giuliani S, Gawriyski LM, Petronczki ÖY, Hadjadj J, Bal SK, Zoghi S, Haimel M, Jimenez Heredia R, Boutboul D, Triebwasser MP, Rialland-Battisti F, Costedoat Chalumeau N, Quartier P, Tangye SG, Fleisher TA, Rezaei N, Romberg N, Latour S, Varjosalo M, Halbritter F, Rieux-Laucat F, Castanon I, Rosenzweig SD, Boztug K., Free PMC Article | 04/23/2022 |
| Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. | Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells.
Hetemäki I, Kaustio M, Kinnunen M, Heikkilä N, Keskitalo S, Nowlan K, Miettinen S, Sarkkinen J, Glumoff V, Andersson N, Kettunen K, Vanhanen R, Nurmi K, Eklund KK, Dunkel J, Mäyränpää MI, Schlums H, Arstila TP, Kisand K, Bryceson YT, Peterson P, Otava U, Syrjänen J, Saarela J, Varjosalo M, Kekäläinen E. | 03/12/2022 |
| Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity. | Germline biallelic mutation affecting the transcription factor Helios causes pleiotropic defects of immunity.
Shahin T, Kuehn HS, Shoeb MR, Gawriyski L, Giuliani S, Repiscak P, Hoeger B, Yüce Petronczki Ö, Bal SK, Zoghi S, Dmytrus J, Seruggia D, Castanon I, Rezaei N, Varjosalo M, Halbritter F, Rosenzweig SD, Boztug K., Free PMC Article | 03/12/2022 |
| Helios is a marker, not a driver, of human Treg stability. | Helios is a marker, not a driver, of human Treg stability.
Lam AJ, Uday P, Gillies JK, Levings MK. | 02/12/2022 |
| Coexpression of Helios in Foxp3(+) Regulatory T Cells and Its Role in Human Disease. | Coexpression of Helios in Foxp3(+) Regulatory T Cells and Its Role in Human Disease.
Yu WQ, Ji NF, Gu CJ, Wang YL, Huang M, Zhang MS., Free PMC Article | 01/1/2022 |
| Helios-expressing CD8(+) T cells are decreased in patients with systemic lupus erythematosus. | Helios-expressing CD8(+) T cells are decreased in patients with systemic lupus erythematosus.
Holderried TA, Kruse M, Serries M, Brossart P, Wolf D, Wolf AM. | 10/16/2021 |
| Differences in Maturation Status and Immune Phenotypes of Circulating Helios(+) and Helios(-) Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals. | Differences in Maturation Status and Immune Phenotypes of Circulating Helios(+) and Helios(-) Tregs and Their Disrupted Correlations With Monocyte Subsets in Autoantibody-Positive T1D Individuals.
Zhang Y, Zhang J, Shi Y, Shen M, Lv H, Chen S, Feng Y, Chen H, Xu X, Yang T, Xu K., Free PMC Article | 09/18/2021 |
| The correlation of helios and neuropilin-1 frequencies with parkinson disease severity. | The correlation of helios and neuropilin-1 frequencies with parkinson disease severity.
Daneshvar Kakhaki R, Kouchaki E, Dadgostar E, Behnam M, Tamtaji OR, Nikoueinejad H, Akbari H. | 06/26/2021 |
| Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells. | Coexpression of FOXP3 and a Helios isoform enhances the effectiveness of human engineered regulatory T cells.
Seng A, Krausz KL, Pei D, Koestler DC, Fischer RT, Yankee TM, Markiewicz MA., Free PMC Article | 06/19/2021 |
| Potential therapeutic effects of interleukin-35 on the differentiation of naive T cells into Helios(+)Foxp3(+) Tregs in clinical and experimental acute respiratory distress syndrome. | Potential therapeutic effects of interleukin-35 on the differentiation of naïve T cells into Helios(+)Foxp3(+) Tregs in clinical and experimental acute respiratory distress syndrome.
Wang C, Xie K, Li K, Lin S, Xu F., Free PMC Article | 04/24/2021 |
| RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells. | RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
Makita S, Takatori H, Iwata A, Tanaka S, Furuta S, Ikeda K, Suto A, Suzuki K, Ramos SBV, Nakajima H., Free PMC Article | 04/3/2021 |
| The results reveal important roles for Helios in enhancing preferential fetal Treg differentiation and fine-tuning eventual Treg function. | Helios enhances the preferential differentiation of human fetal CD4(+) naïve T cells into regulatory T cells.
Ng MSF, Roth TL, Mendoza VF, Marson A, Burt TD., Free PMC Article | 08/1/2020 |
| This work demonstrates abnormal changes in Helios(+) Tregs and soluble GITR in myasthenia gravis, as well as direct regulation of Helios by GITR in the context of Tregulatory cells. | Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis.
Li Y, Yang S, Li Z, Meng H, Jin W, Yang H, Yin W., Free PMC Article | 06/20/2020 |
| The transcription factor Helios, a member of the Ikaros transcription factor family, is expressed in 60-70% of Treg cells in both mouse and man, and is believed to be a marker of tTreg cells. | Helios: still behind the clouds.
Thornton AM, Shevach EM., Free PMC Article | 01/25/2020 |
| the interaction of ODNPs25 in HD or phosphorylation of Thr592 by TCR stimulation interferes with nuclease activity of SAMHD1, thereby stabilizing 3' untranslated region of Foxp3 and Helios mRNAs in long-term culture. | SAMHD1 Posttranscriptionally Controls the Expression of Foxp3 and Helios in Human T Regulatory Cells.
Kim YC, Kim KK, Yoon J, Scott DW, Shevach EM., Free PMC Article | 07/6/2019 |
| these data strongly imply the physiological importance of Helios expression in Tregs, and suggest that the manipulation of Helios may serve as a novel strategy for cancer immunotherapy. | Helios expression in regulatory T cells promotes immunosuppression, angiogenesis and the growth of leukemia cells in pediatric acute lymphoblastic leukemia.
Li X, Li D, Huang X, Zhou P, Shi Q, Zhang B, Ju X. | 03/16/2019 |
| Results indicate that downregulation of Helios mRNA, protein expression and signaling may modulate the development of neurological disorders in children with autism spectrum disorder (ASD). Results provide evidence that immune dysfunction is associated with downregulation of Helios expression in children with ASD. | Downregulation in Helios transcription factor signaling is associated with immune dysfunction in blood leukocytes of autistic children.
Ahmad SF, Nadeem A, Ansari MA, Bakheet SA, Al-Ayadhi LY, Attia SM. | 01/19/2019 |
| The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability. | Analysis of Helios gene expression and Foxp3 TSDR methylation in the newly diagnosed Rheumatoid Arthritis patients.
Zafari P, Yari K, Mostafaei S, Iranshahi N, Assar S, Fekri A, Taghadosi M. | 11/10/2018 |
| Helios mRNA is down-regulated in Treg cells of patients with hypertension. | Down-regulation of Helios Expression in Tregs from Patients with Hypertension.
Chen ZY, Chen F, Wang YG, Wang DH, Jang LL, Cheng LX. | 11/3/2018 |