| CD4[+] regulatory T cells lacking Helios and Eos. | CD4(+) regulatory T cells lacking Helios and Eos.
Polak K, Marchal P, Taroni C, Ebel C, Kirstetter P, Kastner P, Chan S. | 08/16/2023 |
| Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development. | Epistatic genetic interactions between Insm1 and Ikzf2 during cochlear outer hair cell development.
Li S, He S, Lu Y, Jia S, Liu Z. | 06/7/2023 |
| Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells. | Helios represses megakaryocyte priming in hematopoietic stem and progenitor cells.
Cova G, Taroni C, Deau MC, Cai Q, Mittelheisser V, Philipps M, Jung M, Cerciat M, Le Gras S, Thibault-Carpentier C, Jost B, Carlsson L, Thornton AM, Shevach EM, Kirstetter P, Kastner P, Chan S., Free PMC Article | 12/4/2021 |
| Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice. | Ikzf2 Regulates the Development of ICOS(+) Th Cells to Mediate Immune Response in the Spleen of S. japonicum-Infected C57BL/6 Mice.
Xie S, Wei H, Peng A, Xie A, Li J, Fang C, Shi F, Yang Q, Huang H, Xie H, Pan X, Tian X, Huang J., Free PMC Article | 10/30/2021 |
| RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells. | RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells.
Makita S, Takatori H, Iwata A, Tanaka S, Furuta S, Ikeda K, Suto A, Suzuki K, Ramos SBV, Nakajima H., Free PMC Article | 04/3/2021 |
| Our results demonstrated that...Helios has a specific and important role for a correct function of hippocampal calbindin-positive CA1 pyramidal neurons regulating spinogenesis...and that Visinin-like protein 1 (VSNL1) could play an important role in such processes | Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation.
Giralt A, Brito V, Pardo M, Rubio SE, Marion-Poll L, Martín-Ibáñez R, Zamora-Moratalla A, Bosch C, Ballesteros JJ, Blasco E, García-Torralba A, Pascual M, Pumarola M, Alberch J, Ginés S, Martín ED, Segovia J, Soriano E, Canals JM. | 07/25/2020 |
| CD4+ Tconv cells can differentiate into both RORgamma+ and Helios+ pTreg cells. | Developmental and cellular age direct conversion of CD4+ T cells into RORγ+ or Helios+ colon Treg cells.
Pratama A, Schnell A, Mathis D, Benoist C., Free PMC Article | 07/18/2020 |
| Data show that zinc finger protein subfamily 1A 2 (Helios)Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires. | Helios(+) and Helios(-) Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires.
Thornton AM, Lu J, Korty PE, Kim YC, Martens C, Sun PD, Shevach EM., Free PMC Article | 05/30/2020 |
| The transcription factor Helios, a member of the Ikaros transcription factor family, is expressed in 60-70% of Treg cells in both mouse and man, and is believed to be a marker of tTreg cells. | Helios: still behind the clouds.
Thornton AM, Shevach EM., Free PMC Article | 01/25/2020 |
| identification of Ikzf2 (which encodes Helios) as an essential transcription factor in mice that is required for outer hair cells functional maturation and hearing | Helios is a key transcriptional regulator of outer hair cell maturation.
Chessum L, Matern MS, Kelly MC, Johnson SL, Ogawa Y, Milon B, McMurray M, Driver EC, Parker A, Song Y, Codner G, Esapa CT, Prescott J, Trent G, Wells S, Dragich AK, Frolenkov GI, Kelley MW, Marcotti W, Brown SDM, Elkon R, Bowl MR, Hertzano R., Free PMC Article | 06/8/2019 |
| These data provide a genetic basis for the unstable phenotype of Helios-deficient Tregs within the inflammatory environment of tumors and suggest that immune milieu-dependent alterations in gene expression are a central feature of Treg conversion. | Comparative transcriptome analysis reveals distinct genetic modules associated with Helios expression in intratumoral regulatory T cells.
Yates K, Bi K, Haining WN, Cantor H, Kim HJ., Free PMC Article | 08/4/2018 |
| He is involved in the correct development of a subset of striatopallidal medium spiny neurons. | Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons.
Martín-Ibáñez R, Pardo M, Giralt A, Miguez A, Guardia I, Marion-Poll L, Herranz C, Esgleas M, Garcia-Díaz Barriga G, Edel MJ, Vicario-Abejón C, Alberch J, Girault JA, Chan S, Kastner P, Canals JM., Free PMC Article | 09/16/2017 |
| Helios controls certain aspects of Treg-suppressive function, differentiation, and survival. | Helios Controls a Limited Subset of Regulatory T Cell Functions.
Sebastian M, Lopez-Ocasio M, Metidji A, Rieder SA, Shevach EM, Thornton AM., Free PMC Article | 05/28/2016 |
| this study reports that impaired expression of the transcription factor Helios by FoxP3+ CD4 and Qa-1-restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice. | Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Kim HJ, Barnitz RA, Kreslavsky T, Brown FD, Moffett H, Lemieux ME, Kaygusuz Y, Meissner T, Holderried TA, Chan S, Kastner P, Haining WN, Cantor H., Free PMC Article | 11/7/2015 |
| data suggest that a subset of DN T cells, identified by the expression of PD-1 and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 loss as a process associated with self-Ag encounter | Programmed cell death 1 and Helios distinguish TCR-αβ+ double-negative (CD4-CD8-) T cells that derive from self-reactive CD8 T cells.
Rodríguez-Rodríguez N, Apostolidis SA, Penaloza-MacMaster P, Martín Villa JM, Barouch DH, Tsokos GC, Crispín JC., Free PMC Article | 07/25/2015 |
| results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen | Helios defines T cells being driven to tolerance in the periphery and thymus.
Ross EM, Bourges D, Hogan TV, Gleeson PA, van Driel IR. | 09/13/2014 |
| identify Helios as the first marker known to diverge during positive and negative selection of thymocytes | Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB.
Daley SR, Hu DY, Goodnow CC., Free PMC Article | 04/13/2013 |
| Helios regulates IL-2 production in Tregs by suppressing Il2 gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 locus. | Helios induces epigenetic silencing of IL2 gene expression in regulatory T cells.
Baine I, Basu S, Ames R, Sellers RS, Macian F., Free PMC Article | 03/30/2013 |
| Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons. | Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.
Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM., Free PMC Article | 12/22/2012 |
| In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass. | Phenotypic and functional properties of Helios+ regulatory T cells.
Zabransky DJ, Nirschl CJ, Durham NM, Park BV, Ceccato CM, Bruno TC, Tam AJ, Getnet D, Drake CG., Free PMC Article | 08/4/2012 |
| Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. | Helios expression is a marker of T cell activation and proliferation.
Akimova T, Beier UH, Wang L, Levine MH, Hancock WW., Free PMC Article | 02/18/2012 |
| down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription factor in NK cells | Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses.
Narni-Mancinelli E, Jaeger BN, Bernat C, Fenis A, Kung S, De Gassart A, Mahmood S, Gut M, Heath SC, Estellé J, Bertosio E, Vely F, Gastinel LN, Beutler B, Malissen B, Malissen M, Gut IG, Vivier E, Ugolini S. | 02/4/2012 |
| Data show that Helios is selectively upregulated in CD4 T cells during Th2 and TFh responses to alum-protein vaccines in vivo, independently of Foxp3 expression. | Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
Serre K, Bénézech C, Desanti G, Bobat S, Toellner KM, Bird R, Chan S, Kastner P, Cunningham AF, Maclennan IC, Mohr E., Free PMC Article | 10/22/2011 |
| show that Helios is upregulated in CD4(+)CD25(+) regulatory T cells. | A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells.
Getnet D, Grosso JF, Goldberg MV, Harris TJ, Yen HR, Bruno TC, Durham NM, Hipkiss EL, Pyle KJ, Wada S, Pan F, Pardoll DM, Drake CG., Free PMC Article | 05/3/2010 |
| Helios is not essential for T cells; its function can be compensated for by other members of the Ikaros family. | Helios deficiency has minimal impact on T cell development and function.
Cai Q, Dierich A, Oulad-Abdelghani M, Chan S, Kastner P. | 01/21/2010 |