| Gelsolin regulates receptor-mediated and fluid-phase endocytosis in platelets. | Gelsolin regulates receptor-mediated and fluid-phase endocytosis in platelets.
Paul M, Hong F, Falet H, Kim H. | 09/3/2024 |
| Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis via the Actin Cytoskeleton. | Gelsolin Modulates Platelet Dense Granule Secretion and Hemostasis via the Actin Cytoskeleton.
Paul M, Golla K, Kim H. | 02/12/2023 |
| The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3. | The Molecular Chaperone CCT Sequesters Gelsolin and Protects it from Cleavage by Caspase-3.
Cuéllar J, Vallin J, Svanström A, Maestro-López M, Bueno-Carrasco MT, Ludlam WG, Willardson BM, Valpuesta JM, Grantham J. | 05/21/2022 |
| The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes. | The Pathophysiologic Role of Gelsolin in Chronic Kidney Disease: Focus on Podocytes.
Yu CJ, Damaiyanti DW, Yan SJ, Wu CH, Tang MJ, Shieh DB, Liu PP, Liu PY., Free PMC Article | 01/22/2022 |
| Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity. | Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity.
Giampazolias E, Schulz O, Lim KHJ, Rogers NC, Chakravarty P, Srinivasan N, Gordon O, Cardoso A, Buck MD, Poirier EZ, Canton J, Zelenay S, Sammicheli S, Moncaut N, Varsani-Brown S, Rosewell I, Reis e Sousa C., Free PMC Article | 01/8/2022 |
| Gelsolin is an important mediator of Angiotensin II-induced activation of cardiac fibroblasts and fibrosis. | Gelsolin is an important mediator of Angiotensin II-induced activation of cardiac fibroblasts and fibrosis.
Jana S, Aujla P, Hu M, Kilic T, Zhabyeyev P, McCulloch CA, Oudit GY, Kassiri Z. | 10/30/2021 |
| Plasma gelsolin promotes re-epithelialization of the ocular system. | Plasma gelsolin promotes re-epithelialization.
Wittmann J, Dieckow J, Schröder H, Hampel U, Garreis F, Jacobi C, Milczarek A, Hsieh KL, Pulli B, Chen JW, Hoogeboom S, Bräuer L, Paulsen FP, Schob S, Schicht M., Free PMC Article | 10/26/2019 |
| PI3Kalpha drives gelsolin-mediated adverse cytoskeletal remodeling in response to biomechanical stress. | PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
Patel VB, Zhabyeyev P, Chen X, Wang F, Paul M, Fan D, McLean BA, Basu R, Zhang P, Shah S, Dawson JF, Pyle WG, Hazra M, Kassiri Z, Hazra S, Vanhaesebroeck B, McCulloch CA, Oudit GY., Free PMC Article | 02/16/2019 |
| Induction of cell stress alters the actin cytoskeleton in intestinal epithelial cells via changes in the actin-binding proteins villin-1 and gelsolin. | Villin-1 and Gelsolin Regulate Changes in Actin Dynamics That Affect Cell Survival Signaling Pathways and Intestinal Inflammation.
Roy S, Esmaeilniakooshkghazi A, Patnaik S, Wang Y, George SP, Ahrorov A, Hou JK, Herron AJ, Sesaki H, Khurana S., Free PMC Article | 05/12/2018 |
| Myelin loss and subsequent axon degeneration contributes to a variety of neurological diseases, such as multiple sclerosis (MS). | LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.
Shao Z, Lee X, Huang G, Sheng G, Henderson CE, Louvard D, Sohn J, Pepinsky B, Mi S., Free PMC Article | 08/19/2017 |
| free actin likely contributes to impaired host defense by blocking scavenger receptor binding of bacteria. | Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin.
Ordija CM, Chiou TT, Yang Z, Deloid GM, de Oliveira Valdo M, Wang Z, Bedugnis A, Noah TL, Jones S, Koziel H, Kobzik L., Free PMC Article | 08/5/2017 |
| gelsolin plays a critical role in airway smooth muscle relaxation. | Impaired Relaxation of Airway Smooth Muscle in Mice Lacking the Actin-Binding Protein Gelsolin.
Mikami M, Zhang Y, Danielsson J, Joell T, Yong HM, Townsend E, Khurana S, An SS, Emala CW., Free PMC Article | 08/5/2017 |
| We conclude that a nanobody-based gene therapy using adeno-associated viruses shows great potential as a novel strategy in gelsolin amyloidosis and potentially other amyloid diseases. | AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model.
Verhelle A, Nair N, Everaert I, Van Overbeke W, Supply L, Zwaenepoel O, Peleman C, Van Dorpe J, Lahoutte T, Devoogdt N, Derave W, Chuah MK, VandenDriessche T, Gettemans J. | 05/20/2017 |
| The data presented here reveal an additional level of interplay between CCT and actin mediated via gelsolin, suggesting that CCT may influence processes depending on gelsolin activity, such as cell motility. | The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro.
Svanström A, Grantham J., Free PMC Article | 10/1/2016 |
| novel roles for actin-depolymerizing factor and cofilin-1 in regulating the remodeling and permeability of epithelial junctions | Actin-Depolymerizing Factor and Cofilin-1 Have Unique and Overlapping Functions in Regulating Intestinal Epithelial Junctions and Mucosal Inflammation.
Wang D, Naydenov NG, Feygin A, Baranwal S, Kuemmerle JF, Ivanov AI., Free PMC Article | 09/10/2016 |
| The data of this study identify overlapping functions for ADF and n-cofilin in presynaptic physiology and vesicle in mice. trafficking. | ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis.
Wolf M, Zimmermann AM, Görlich A, Gurniak CB, Sassoè-Pognetto M, Friauf E, Witke W, Rust MB. | 05/14/2016 |
| GSNs might play a regulatory role in the suppression of the tissue damage induced by acute radiation exposure | Gelsolin: role of a functional protein in mitigating radiation injury.
Li M, Cui F, Cheng Y, Han L, Wang J, Sun D, Liu YL, Zhou PK, Min R. | 04/30/2016 |
| Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes | Influence of gelsolin deficiency on excitation contraction coupling in adult murine cardiomyocytes.
Weisser-Thomas J, Kempelmann H, Nickenig G, Grohe C, Djoufack P, Fink K, Meyer R. | 04/2/2016 |
| Clic1 have a role in migration and invasion in hepatocarcinoma maybe via modulating the expression of Annexin A7 and Gelsolin. | Clic1 plays a role in mouse hepatocarcinoma via modulating Annexin A7 and Gelsolin in vitro and in vivo.
Zhang J, Li M, Song M, Chen W, Mao J, Song L, Wei Y, Huang Y, Tang J. | 10/17/2015 |
| our data demonstrate that a cell-autonomous program consisting of a stress-induced Atf3-gelsolin cascade affects the change in dendritic spine morphology in models of tuberous sclerosis complex | The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.
Nie D, Chen Z, Ebrahimi-Fakhari D, Di Nardo A, Julich K, Robson VK, Cheng YC, Woolf CJ, Heiman M, Sahin M., Free PMC Article | 10/17/2015 |
| Plasma gelsolin levels decrease in the blood of mice with type II diabetes. | Plasma gelsolin levels decrease in diabetic state and increase upon treatment with F-actin depolymerizing versions of gelsolin.
Khatri N, Sagar A, Peddada N, Choudhary V, Chopra BS, Garg V, Garg R, Ashish., Free PMC Article | 07/25/2015 |
| The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells. | The actin-binding proteins eps8 and gelsolin have complementary roles in regulating the growth and stability of mechanosensory hair bundles of mammalian cochlear outer hair cells.
Olt J, Mburu P, Johnson SL, Parker A, Kuhn S, Bowl M, Marcotti W, Brown SD., Free PMC Article | 10/4/2014 |
| Burn-induced cerebral gelsolin expression is involved in the activation of both monocytes and astroglial cells, thereby playing a crucial role in the subsequent inflammation-induced neural apoptosis following burn injury. | Burn injury induces gelsolin expression and cleavage in the brain of mice.
Zhang QH, Li JC, Dong N, Tang LM, Zhu XM, Sheng ZY, Yao YM. | 09/28/2013 |
| study concludes that cell adhesion to collagen presented on beads activates Ca(2 ) entry and promotes the formation of phagosomes enriched with NMMIIA and gelsolin | Collagen remodeling by phagocytosis is determined by collagen substrate topology and calcium-dependent interactions of gelsolin with nonmuscle myosin IIA in cell adhesions.
Arora PD, Wang Y, Bresnick A, Dawson J, Janmey PA, McCulloch CA., Free PMC Article | 09/14/2013 |
| The F-actin severing activity of ADF/Co fi lin organizes space for the protrusion and bundling of microtubules, the backbone of neurites. ADF/Co fi lin organizes the cytoskeleton to drive actin retrograde fl ow and thus break the spherical shape of neurons. | ADF/cofilin-mediated actin retrograde flow directs neurite formation in the developing brain.
Flynn KC, Hellal F, Neukirchen D, Jacob S, Tahirovic S, Dupraz S, Stern S, Garvalov BK, Gurniak C, Shaw AE, Meyn L, Wedlich-Söldner R, Bamburg JR, Small JV, Witke W, Bradke F. | 03/2/2013 |