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    Zfp57 zinc finger protein 57 [ Mus musculus (house mouse) ]

    Gene ID: 22715, updated on 9-Dec-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.

    Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.
    Zhao J, Zhao J.

    01/8/2024
    Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.

    Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.
    Acurzio B, Verma A, Polito A, Giaccari C, Cecere F, Fioriniello S, Della Ragione F, Fico A, Cerrato F, Angelini C, Feil R, Riccio A., Free PMC Article

    11/6/2021
    A group of functionally significant composite DNA elements (ZFP57 binding site (ZFBS)-Morph overlaps) that may play dual roles in the regulation of allele-specific gene expression.

    Imprinted control regions include composite DNA elements consisting of the ZFP57 binding site overlapping MLL1 morphemes.
    Bina M.

    10/7/2017
    another function of ZFP57 in early embryogenesis is to repress cis-acting regulatory elements whose activity is not yet required.

    ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells.
    Riso V, Cammisa M, Kukreja H, Anvar Z, Verde G, Sparago A, Acurzio B, Lad S, Lonardo E, Sankar A, Helin K, Feil R, Fico A, Angelini C, Grimaldi G, Riccio A., Free PMC Article

    06/24/2017
    Data show that ZFP57 binding is affected by single nucleotide polymorphism (SNPs) and closely associated TGCCGC motif sequences that are present at the target sites.

    ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.
    Anvar Z, Cammisa M, Riso V, Baglivo I, Kukreja H, Sparago A, Girardot M, Lad S, De Feis I, Cerrato F, Angelini C, Feil R, Pedone PV, Grimaldi G, Riccio A., Free PMC Article

    07/16/2016
    Within established mouse imprinted clusters, ZFP57 specifically binds known or predicted imprinting control region elements, but does not interact with secondary somatically differentially methylated regions (DMRs) or germline DMRs that are not imprinting controlling.

    Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.
    Strogantsev R, Krueger F, Yamazawa K, Shi H, Gould P, Goldman-Roberts M, McEwen K, Sun B, Pedersen R, Ferguson-Smith AC., Free PMC Article

    06/4/2016
    ZFP57 may modulate NOTCH signaling during cardiac development.

    Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
    Shamis Y, Cullen DE, Liu L, Yang G, Ng SF, Xiao L, Bell FT, Ray C, Takikawa S, Moskowitz IP, Cai CL, Yang X, Li X., Free PMC Article

    07/4/2015
    Taken together, our results suggest that Nanog positively regulates Zfp57 expression in multiple types of cells.

    Nanog positively regulates Zfp57 expression in mouse embryonic stem cells.
    Yamaguchi Y, Takamura H, Tada Y, Akagi T, Oyama K, Miyashita T, Tajima H, Kitagawa H, Fushida S, Yokota T, Ohta T, Koide H.

    02/14/2015
    Mouse and human ZFP57 are orthologs despite relatively low sequence identity.

    Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells.
    Takikawa S, Wang X, Ray C, Vakulenko M, Bell FT, Li X., Free PMC Article

    05/24/2014
    Data suggest that Glu182 in the DNA binding site in zinc finger motif of Zfp57 plays important role in binding specificity and affinity for 5-carboxylcytosine and other cytosine analogs.

    DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å.
    Liu Y, Olanrewaju YO, Zhang X, Cheng X., Free PMC Article

    03/8/2014
    the structure of the DNA-binding domain of Zfp57, consisting of two adjacent zinc fingers, in complex with fully methylated DNA

    An atomic model of Zfp57 recognition of CpG methylation within a specific DNA sequence.
    Liu Y, Toh H, Sasaki H, Zhang X, Cheng X., Free PMC Article

    01/5/2013
    ZFP57 may recruit DNA methyltransferases to its target regions to maintain DNA methylation imprint, and this interaction is likely facilitated by KAP1/TRIM28/TIF1beta.

    Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain.
    Zuo X, Sheng J, Lau HT, McDonald CM, Andrade M, Cullen DE, Bell FT, Iacovino M, Kyba M, Xu G, Li X., Free PMC Article

    03/10/2012
    In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions.

    In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions.
    Quenneville S, Verde G, Corsinotti A, Kapopoulou A, Jakobsson J, Offner S, Baglivo I, Pedone PV, Grimaldi G, Riccio A, Trono D., Free PMC Article

    12/31/2011
    Zpf57 maintains both maternal and paternal genomic imprints.

    A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints.
    Li X, Ito M, Zhou F, Youngson N, Zuo X, Leder P, Ferguson-Smith AC., Free PMC Article

    01/21/2010
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