| Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice. | Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice.
Wang F, Chander A, Yoon Y, Welton JM, Wallingford MC, Espejo-Serrano C, Bustos F, Findlay GM, Mager J, Bach I., Free PMC Article | 12/29/2023 |
| ChIP-seq analyses show high colocalization of HMGNs and of REX1, a zinc finger protein, at promoters and enhancers. Loss of HMGNs preferentially reduces the specific binding of REX1 to these chromatin regulatory sites. Thus, HMGNs affects both the expression and the chromatin binding specificity of REX1. | Epigenetic regulation of REX1 expression and chromatin binding specificity by HMGNs.
Zhang S, Deng T, Tang W, He B, Furusawa T, Ambs S, Bustin M., Free PMC Article | 11/23/2019 |
| RNF12 targets pluripotency protein REX1 for degradation to initiate random X chromosome inactivation in embryonic stem cells. | REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice.
Gontan C, Mira-Bontenbal H, Magaraki A, Dupont C, Barakat TS, Rentmeester E, Demmers J, Gribnau J., Free PMC Article | 04/27/2019 |
| Data show that zinc finger protein 42 (Rex1) and zinc finger and SCAN domain containing 4D/4C (Zscan4D/4C) correlate with the cell-cycle length under different mechanisms. | Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells.
Nakai-Futatsugi Y, Niwa H., Free PMC Article | 01/14/2017 |
| Results show that a novel pluripotency regulator, REX1, is essential for pluripotency and reprogramming. | Unveiling the critical role of REX1 in the regulation of human stem cell pluripotency.
Son MY, Choi H, Han YM, Cho YS. | 09/20/2014 |
| Rex1 plays a role during preimplantation development and alters expression levels of Zscan4. | Functional analysis of Rex1 during preimplantation development.
Climent M, Alonso-Martin S, Pérez-Palacios R, Guallar D, Benito AA, Larraga A, Fernández-Juan M, Sanz M, de Diego A, Seisdedos MT, Muniesa P, Schoorlemmer J., Free PMC Article | 06/29/2013 |
| Results show that Rex1 regulates endogenous retroviral element expression in mouse embryonic stem cells and during pre-implantation development and suggest that Rex1 and its relatives have evolved as regulators of endogenous retroviral transcription. | Expression of endogenous retroviruses is negatively regulated by the pluripotency marker Rex1/Zfp42.
Guallar D, Pérez-Palacios R, Climent M, Martínez-Abadía I, Larraga A, Fernández-Juan M, Vallejo C, Muniesa P, Schoorlemmer J., Free PMC Article | 12/29/2012 |
| RNF12 causes REX1 breakdown through dose-dependent catalysis, thereby representing an important pathway to initiate X-chromosome inactivation | RNF12 initiates X-chromosome inactivation by targeting REX1 for degradation.
Gontan C, Achame EM, Demmers J, Barakat TS, Rentmeester E, van IJcken W, Grootegoed JA, Gribnau J. | 07/21/2012 |
| the involvement of Rex-1 in control of Polycomb target genes during pluripotency or differentiation. | Association of Rex-1 to target genes supports its interaction with Polycomb function.
Garcia-Tuñon I, Guallar D, Alonso-Martin S, Benito AA, Benítez-Lázaro A, Pérez-Palacios R, Muniesa P, Climent M, Sánchez M, Vidal M, Schoorlemmer J. | 12/3/2011 |
| loss of Rex1 leads to impaired testicular function. | Rex1 (Zfp42) null mice show impaired testicular function, abnormal testis morphology, and aberrant gene expression.
Rezende NC, Lee MY, Monette S, Mark W, Lu A, Gudas LJ., Free PMC Article | 10/1/2011 |
| the functional connection of Rex1 to genomic imprinting represents another case where newly made genes have co-evolved with lineage-specific phenomena. | Rex1/Zfp42 as an epigenetic regulator for genomic imprinting.
Kim JD, Kim H, Ekram MB, Yu S, Faulk C, Kim J., Free PMC Article | 05/21/2011 |
| The disruption of the Rex1 gene enhanced the expression of ectoderm, mesoderm, and endoderm markers as compared to wild-type embryonic stem cells | Analysis of Rex1 (zfp42) function in embryonic stem cell differentiation.
Scotland KB, Chen S, Sylvester R, Gudas LJ., Free PMC Article | 01/21/2010 |
| Rex1 should be regarded just as a marker of pluripotency without functional significance | Rex1/Zfp42 is dispensable for pluripotency in mouse ES cells.
Masui S, Ohtsuka S, Yagi R, Takahashi K, Ko MS, Niwa H., Free PMC Article | 01/21/2010 |
| Rex1, which is highly expressed in stem cells, inhibits signaling via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway, thereby modulating the differentiation of F9 cells. | Transcriptional activation of the suppressor of cytokine signaling-3 (SOCS-3) gene via STAT3 is increased in F9 REX1 (ZFP-42) knockout teratocarcinoma stem cells relative to wild-type cells.
Xu J, Sylvester R, Tighe AP, Chen S, Gudas LJ., Free PMC Article | 01/21/2010 |
| Rex-1 transcription factor regulates the differentiation of F9 stem cells along several distinct cell lineages found in the early embryo. | Retinoic acid induces parietal endoderm but not primitive endoderm and visceral endoderm differentiation in F9 teratocarcinoma stem cells with a targeted deletion of the Rex-1 (Zfp-42) gene.
Thompson JR, Gudas LJ. | 01/21/2010 |
| Rex-1 marker was assessed using flow cytometry and gene expression profiling. | Expansion of undifferentiated murine embryonic stem cells as aggregates in suspension culture bioreactors.
Cormier JT, zur Nieden NI, Rancourt DE, Kallos MS. | 01/21/2010 |
| Embryonic stem cell marker Rex-1 and the pluripotent stem cell marker Oct-4 are spontaneously expressed by untreated mesenchymal stem cells. | Undifferentiated mouse mesenchymal stem cells spontaneously express neural and stem cell markers Oct-4 and Rex-1.
Lamoury FM, Croitoru-Lamoury J, Brew BJ. | 01/21/2010 |