| Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis. | Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis.
Ji XY, Guo YX, Wang LB, Wu WC, Wang JQ, He J, Gao R, Rasouli J, Gao MY, Wang ZH, Xiao D, Zhang WF, Ciric B, Zhang Y, Li X., Free PMC Article | 02/9/2024 |
| DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact. | DUSP15 expression is reduced in the hippocampus of Myrf knock-out mice but attention and object recognition memory remain intact.
Rawlings-Mortimer F, Gullino LS, Rühling S, Ashton A, Barkus C, Johansen-Berg H., Free PMC Article | 02/10/2023 |
| Nanophthalmos-Associated MYRF Gene Mutation Causes Ciliary Zonule Defects in Mice. | Nanophthalmos-Associated MYRF Gene Mutation Causes Ciliary Zonule Defects in Mice.
Yu X, Sun N, Yang X, Zhao Z, Su X, Zhang J, He Y, Lin Y, Ge J, Fan Z., Free PMC Article | 10/2/2021 |
| findings highlight the importance of the interplay between TMEM98 and MYRF in determining the size of the eye | The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.
Cross SH, Mckie L, Hurd TW, Riley S, Wills J, Barnard AR, Young F, MacLaren RE, Jackson IJ., Free PMC Article | 07/25/2020 |
| this study identifies the N-terminal-most domain as the transactivation domain of Myrf. | Elucidating the transactivation domain of the pleiotropic transcription factor Myrf.
Choi JO, Fan C, Kim D, Sharif M, An H, Park Y., Free PMC Article | 10/26/2019 |
| TMEM98 membrane protein physically interacts with MYRF in the endoplasmic reticulum and subsequently blocks its self-cleavage. | Interactive Repression of MYRF Self-Cleavage and Activity in Oligodendrocyte Differentiation by TMEM98 Protein.
Huang H, Teng P, Du J, Meng J, Hu X, Tang T, Zhang Z, Qi YB, Qiu M., Free PMC Article | 10/12/2019 |
| results thus suggest that Fbxw7 controls the transcription of MyRF target genes in various tissues through regulation of MyRF protein stability in a manner dependent on MyRF phosphorylation by GSK-3. | Degradation of the endoplasmic reticulum-anchored transcription factor MyRF by the ubiquitin ligase SCF(Fbxw7) in a manner dependent on the kinase GSK-3.
Nakayama S, Yumimoto K, Kawamura A, Nakayama KI., Free PMC Article | 12/22/2018 |
| Purification, crystallization and X-ray analysis of DNA-binding domain of MRF has been reported. | DNA-binding domain of myelin-gene regulatory factor: purification, crystallization and X-ray analysis.
Wu W, Zhen X, Shi N., Free PMC Article | 12/9/2017 |
| molecular mechanisms underlying the homo-trimerization of Myrf N-terminal fragments and the homo-trimeric DNA binding of Myrf N-terminal fragments | Homo-trimerization is essential for the transcription factor function of Myrf for oligodendrocyte differentiation.
Kim D, Choi JO, Fan C, Shearer RS, Sharif M, Busch P, Park Y., Free PMC Article | 09/2/2017 |
| mutant huntingtin binds abnormally to MYRF and affects its transcription activity | Mutant huntingtin downregulates myelin regulatory factor-mediated myelin gene expression and affects mature oligodendrocytes.
Huang B, Wei W, Wang G, Gaertig MA, Feng Y, Wang W, Li XJ, Li S., Free PMC Article | 05/23/2015 |
| Here we identify Myrf as an oligodendrocyte-specific target of Sox10 and map a Sox10 responsive enhancer to an evolutionarily conserved element in intron 1 of the Myrf gene | The transcription factors Sox10 and Myrf define an essential regulatory network module in differentiating oligodendrocytes.
Hornig J, Fröb F, Vogl MR, Hermans-Borgmeyer I, Tamm ER, Wegner M., Free PMC Article | 02/21/2015 |
| Expression of MRF within the adult central nervous system (CNS) is critical to maintain oligodendrocyte identity and integrity of CNS myelin. | Myelin gene regulatory factor is required for maintenance of myelin and mature oligodendrocyte identity in the adult CNS.
Koenning M, Jackson S, Hay CM, Faux C, Kilpatrick TJ, Willingham M, Emery B., Free PMC Article | 11/17/2012 |
| NPC1 protein was expressed in oligodendrocytes and the amount of myelin protein was generally decreased in all parts of the brain and spinal cord in NPC1-mutant mice | Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse.
Yan X, Lukas J, Witt M, Wree A, Hübner R, Frech M, Köhling R, Rolfs A, Luo J. | 04/14/2012 |
| Study identifies gene model 98, which we have named myelin gene regulatory factor (MRF), as a transcriptional regulator required for CNS myelination. | Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination.
Emery B, Agalliu D, Cahoy JD, Watkins TA, Dugas JC, Mulinyawe SB, Ibrahim A, Ligon KL, Rowitch DH, Barres BA., Free PMC Article | 01/21/2010 |