| Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis. | Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis.
Seo JY, Kang JS, Kim YL, Jo YW, Kim JH, Hann SH, Park J, Park I, Park H, Yoo K, Rhee J, Park JW, Ha YC, Kong YY., Free PMC Article | 03/20/2021 |
| Mib1 is necessary for the Notch activation in adjacent retinal progenitor cell (RPC)The retinal pigment epithelium (RPE) expresses active Notch ligands for adjacent RPC | The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.
Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW. | 05/6/2017 |
| Deletion of Mib1 resulted in an increase in the fraction of pendrin positive intercalated cells in the kidney. | Altered response of pendrin-positive intercalated cells in the kidney of Hoxb7-Cre;Mib1f/f mice.
Nam SA, Kim WY, Kim YM, Kim H, Kong YY, Lee SM, Kim J. | 02/13/2016 |
| Loss of MIB1 and dismantling of the apical secretory apparatus was the earliest quantifiable aberration in zymogenic cells undergoing transition to a precancerous metaplastic state in mouse. | The ubiquitin ligase Mindbomb 1 coordinates gastrointestinal secretory cell maturation.
Capoccia BJ, Jin RU, Kong YY, Peek RM Jr, Fassan M, Rugge M, Mills JC., Free PMC Article | 05/25/2013 |
| These data suggest that Mib1-mediated Notch signaling is essential for long-lasting synaptic plasticity and memory formation in the rodent hippocampus. | Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway.
Yoon KJ, Lee HR, Jo YS, An K, Jung SY, Jeong MW, Kwon SK, Kim NS, Jeong HW, Ahn SH, Kim KT, Lee K, Kim E, Kim JH, Choi JS, Kaang BK, Kong YY., Free PMC Article | 05/18/2013 |
| Mib1 is a major component of the signal-sending cells required to provide Notch ligand activity for specifying neurons and glia in the spinal cord | The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord.
Kang K, Lee D, Hong S, Park SG, Song MR., Free PMC Article | 04/6/2013 |
| In contrast to delta-like 1 (Dll1) protein, delta-like 4 (deltall4) function relies on a combination of factors, including strong Mindbomb1 (Mib1) association, ubiquitination, and internalization and recycling back to the cell surface, to engage Notch1 effectively. | Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development.
Shah DK, Mohtashami M, Zúñiga-Pflücker JC. | 02/23/2013 |
| Mib1 in dendritic cells is critical for the activation of Notch signaling in CD4(+) T cells | Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation.
Jeong HW, Kim JH, Kim JY, Ha SJ, Kong YY., Free PMC Article | 09/8/2012 |
| Data show that Mind bomb 1 (Mib1) is required for correct proximodistal (P-D) patterning of the developing pancreas and beta-cell formation. | Mind bomb 1 is required for pancreatic β-cell formation.
Horn S, Kobberup S, Jørgensen MC, Kalisz M, Klein T, Kageyama R, Gegg M, Lickert H, Lindner J, Magnuson MA, Kong YY, Serup P, Ahnfelt-Rønne J, Jensen JN., Free PMC Article | 08/18/2012 |
| show that exogenously expressed Mib1 could partially rescue the phenotypes associated with miR-137 overexpression. | MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Smrt RD, Szulwach KE, Pfeiffer RL, Li X, Guo W, Pathania M, Teng ZQ, Luo Y, Peng J, Bordey A, Jin P, Zhao X., Free PMC Article | 09/20/2010 |
| Myeloproliferative disease development in the Mib1 CKO mice is due to defective Notch activation in the nonhematopoietic cells. | Defective Notch activation in microenvironment leads to myeloproliferative disease.
Kim YW, Koo BK, Jeong HW, Yoon MJ, Song R, Shin J, Jeong DC, Kim SH, Kong YY. | 01/21/2010 |
| Mib1 is the essential E3 ligase in T and marginal zone B cell development, through the regulation of Notch ligands in the thymic and splenic microenvironments. | Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development.
Song R, Kim YW, Koo BK, Jeong HW, Yoon MJ, Yoon KJ, Jun DJ, Im SK, Shin J, Kong MP, Kim KT, Yoon K, Kong YY., Free PMC Article | 01/21/2010 |
| data provide the first evidence that Mib1 is essential for Jagged as well as Deltalike ligand-mediated Notch signaling in mammalian development, while Neur1, Neur2, and Mib2 are dispensable | An obligatory role of mind bomb-1 in notch signaling of mammalian development.
Koo BK, Yoon MJ, Yoon KJ, Im SK, Kim YY, Kim CH, Suh PG, Jan YN, Kong YY., Free PMC Article | 01/21/2010 |
| These results suggest that Mib1 is important for intraembryonic hematopoiesis not only in the aortic endothelium but also in the subaortic patches. | Mind bomb-1 is essential for intraembryonic hematopoiesis in the aortic endothelium and the subaortic patches.
Yoon MJ, Koo BK, Song R, Jeong HW, Shin J, Kim YW, Kong YY, Suh PG., Free PMC Article | 01/21/2010 |
| A targeted mutation of Mib1 in mice results in embryonic lethality;MIB1 activity is required for S3 cleavage of the Notch1 receptor. | Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.
Barsi JC, Rajendra R, Wu JI, Artzt K. | 01/21/2010 |
| mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis, vasculogenesis and cardiogenesis. | Mind bomb 1 is essential for generating functional Notch ligands to activate Notch.
Koo BK, Lim HS, Song R, Yoon MJ, Yoon KJ, Moon JS, Kim YW, Kwon MC, Yoo KW, Kong MP, Lee J, Chitnis AB, Kim CH, Kong YY. | 01/21/2010 |
| Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1 | Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.
Song R, Koo BK, Yoon KJ, Yoon MJ, Yoo KW, Kim HT, Oh HJ, Kim YY, Han JK, Kim CH, Kong YY. | 01/21/2010 |