| Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling. | Chronic stress induces Alzheimer's disease-like pathologies through DNA damage-Chk1-CIP2A signaling.
Wang Z, Zhang L, Yang J, Zeng Y, Su C, Yao M, Zhang H, Hu W, Liu Y, Lai Y, Wang X, Zeng J, Liu R., Free PMC Article | 10/11/2024 |
| Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes. | Oocytes can repair DNA damage during meiosis via a microtubule-dependent recruitment of CIP2A-MDC1-TOPBP1 complex from spindle pole to chromosomes.
Leem J, Kim JS, Oh JS., Free PMC Article | 06/13/2023 |
| Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression. | Oct4 reduction contributes to testicular injury of unilateral testicular torsion in mice model and apoptotic death of Sertoli cells through mediating CIP2A expression.
Zhang H, Zhu Y, Jin C, Shi L, Xie Y, Sun X, Li P, Zhu X, Dai Q, Yang F, Xie X, Qin L. | 02/24/2023 |
| CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization. | CIP2A deficiency promotes depression-like behaviors in mice through inhibition of dendritic arborization.
Hu WT, Liuyang ZY, Tian Y, Liang JW, Zhang XL, Zhang HL, Wang G, Huo Y, Shentu YP, Wang JZ, Wang XC, Lu YM, Westermarck J, Man HY, Liu R., Free PMC Article | 12/17/2022 |
| Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling. | Chk1 Inhibition Ameliorates Alzheimer's Disease Pathogenesis and Cognitive Dysfunction Through CIP2A/PP2A Signaling.
Hu W, Wang Z, Zhang H, Mahaman YAR, Huang F, Meng D, Zhou Y, Wang S, Jiang N, Xiong J, Westermarck J, Lu Y, Wang J, Wang X, Shentu Y, Liu R., Free PMC Article | 07/2/2022 |
| ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease. | ChK1 activation induces reactive astrogliosis through CIP2A/PP2A/STAT3 pathway in Alzheimer's disease.
Zhou Y, Liu X, Ma S, Zhang N, Yang D, Wang L, Ye S, Zhang Q, Ruan J, Ma J, Wang S, Jiang N, Zhao Z, Zhao S, Zheng C, Fan X, Gong Y, Abdoul Razak MY, Hu W, Pan J, Wang X, Fan J, Li J, Liu R, Shentu Y. | 03/5/2022 |
| Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice. | Polyphyllin I attenuates cognitive impairments and reduces AD-like pathology through CIP2A-PP2A signaling pathway in 3XTg-AD mice.
Zhou Y, Yang D, Chen H, Zheng C, Jiang H, Liu X, Huang X, Ye S, Song S, Jiang N, Zhao Z, Ma S, Ma J, Huang K, Chen C, Fan X, Gong Y, Wang X, Fan J, Liu R, Shentu Y. | 04/24/2021 |
| CIP2A-mediated PP2A inhibition drives tau/APP hyperphosphorylation and increases APP beta-cleavage and Abeta production. | CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.
Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY, Liu R., Free PMC Article | 12/7/2019 |
| that CIP2A-promoted astrogliosis induces synaptic degeneration and cognitive deficits in Alzheimer's disease | CIP2A-promoted astrogliosis induces AD-like synaptic degeneration and cognitive deficits.
Shentu YP, Hu WT, Zhang Q, Huo Y, Liang JW, Liuyang ZY, Zhou H, Wei H, Ke D, Wang XC, Wang JZ, Man HY, Westermarck J, Liu R., Free PMC Article | 07/13/2019 |
| CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation in mouse oocytes | CIP2A acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation.
Wang H, Choe MH, Lee IW, Namgoong S, Kim JS, Kim NH, Oh JS. | 11/11/2017 |
| Knockdown of CIP2A by stable CIP2A siRNA transfection inhibited MDA-MB-231 cell proliferation, invasion, colony growth in vitro, and xenograft growth and metastasis in vivo of breast cancer in mice. | Clinical significance of sCIP2A levels in breast cancer.
Xing ML, Lu YF, Wang DF, Zou XY, Zhang SX, Yun Z. | 09/17/2016 |
| CIP2A as a hitherto unrecognized mediator of T-cell activation. | CIP2A Promotes T-Cell Activation and Immune Response to Listeria monocytogenes Infection.
Côme C, Cvrljevic A, Khan MM, Treise I, Adler T, Aguilar-Pimentel JA, Au-Yeung B, Sittig E, Laajala TD, Chen Y, Oeder S, Calzada-Wack J, Horsch M, Aittokallio T, Busch DH, Ollert MW, Neff F, Beckers J, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Chen Z, Lahesmaa R, Westermarck J., Free PMC Article | 08/27/2016 |
| Downregulation of CIP2A suppresses cell proliferation and growth of nasopharyngeal carcinoma. | Overexpression of CIP2A is an independent prognostic indicator in nasopharyngeal carcinoma and its depletion suppresses cell proliferation and tumor growth.
Liu N, He QM, Chen JW, Li YQ, Xu YF, Ren XY, Sun Y, Mai HQ, Shao JY, Jia WH, Kang TB, Zeng MS, Ma J., Free PMC Article | 01/17/2015 |
| CIP2A strongly interacts with NEK2 during G2/M phase, thereby enhancing NEK2 kinase activity to facilitate centrosome separation in a PP1- and PP2A-independent manner. | Cancerous inhibitor of protein phosphatase 2A (CIP2A) protein is involved in centrosome separation through the regulation of NIMA (never in mitosis gene A)-related kinase 2 (NEK2) protein activity.
Jeong AL, Lee S, Park JS, Han S, Jang CY, Lim JS, Lee MS, Yang Y., Free PMC Article | 03/22/2014 |
| Data show that CIP2A expression can be systematically inhibited without severe consequences to normal mouse development and viability may have clinical relevance regarding targeting of oncogenic CIP2A for future cancer therapies. | CIP2A promotes proliferation of spermatogonial progenitor cells and spermatogenesis in mice.
Ventelä S, Côme C, Mäkelä JA, Hobbs RM, Mannermaa L, Kallajoki M, Chan EK, Pandolfi PP, Toppari J, Westermarck J., Free PMC Article | 06/30/2012 |
| Loss of CIP2A in Myc-overexpressing neural progenitor cells significantly reduces the ability of Myc to increase self-renewal and proliferation. | CIP2A increases self-renewal and is linked to Myc in neural progenitor cells.
Kerosuo L, Fox H, Perälä N, Ahlqvist K, Suomalainen A, Westermarck J, Sariola H, Wartiovaara K. | 10/30/2010 |