| Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development. | Effects of Wnt10a and Wnt10b Double Mutations on Tooth Development.
Yoshinaga K, Yasue A, Mitsui SN, Minegishi Y, Oyadomari S, Imoto I, Tanaka E., Free PMC Article | 03/2/2023 |
| Deficiency of Wnt10a causes female infertility via the beta-catenin/Cyp19a1 pathway in mice. | Deficiency of Wnt10a causes female infertility via the β-catenin/Cyp19a1 pathway in mice.
Zhang JH, Tasaki T, Tsukamoto M, Wang KY, Azuma K., Free PMC Article | 05/28/2022 |
| The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis. | The Shh/Gli signaling cascade regulates myofibroblastic activation of lung-resident mesenchymal stem cells via the modulation of Wnt10a expression during pulmonary fibrogenesis.
Cao H, Chen X, Hou J, Wang C, Xiang Z, Shen Y, Han X. | 09/26/2020 |
| This study was the first to histologically evaluate the bone, fat and muscle phenotypes of Wnt10a knockout mice. | Findings as a starting point to unravel the underlying mechanisms of in vivo interactions involving Wnt10a in bone, fat and muscle.
Tsukamoto M, Wang KY, Tasaki T, Murata Y, Okada Y, Yamanaka Y, Nakamura E, Yamada S, Izumi H, Zhou Q, Azuma K, Sasaguri Y, Kohno K, Sakai A. | 02/22/2020 |
| WNT10a critical role in the stromagenesis and melanoma growth. | Depletion of WNT10A Prevents Tumor Growth by Suppressing Microvessels and Collagen Expression.
Kumagai M, Guo X, Wang KY, Izumi H, Tsukamoto M, Nakashima T, Tasaki T, Kurose N, Uramoto H, Sasaguri Y, Kohno K, Yamada S., Free PMC Article | 07/27/2019 |
| Human and mouse WNT10A mutant palmoplantar and tongue epithelia also display specific differentiation defects that are mimicked by loss of the transcription factor KLF4. | WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation.
Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, Cowart BJ, Tordoff M, Liu F, Zhu X, Barlow LA, Rubin AI, McGrath JA, Morrisey EE, Chu EY, Millar SE., Free PMC Article | 11/24/2018 |
| Deletion of WNT10A resulted in the delayed wound healing associated with suppressed stromagenesis, especially in fibroblasts/myofibroblasts. | Critical in vivo roles of WNT10A in wound healing by regulating collagen expression/synthesis in WNT10A-deficient mice.
Wang KY, Yamada S, Izumi H, Tsukamoto M, Nakashima T, Tasaki T, Guo X, Uramoto H, Sasaguri Y, Kohno K., Free PMC Article | 07/28/2018 |
| The authors conclude that inhibiting DNA methylation by 5-Aza-dC mutual-exclusively regulates the lineage determination of adipogenesis and osteoblastogenesis by demethylating Wnt10a gene and upregulating its expression. | Inhibiting DNA methylation switches adipogenesis to osteoblastogenesis by activating Wnt10a.
Chen YS, Wu R, Yang X, Kou S, MacDougald OA, Yu L, Shi H, Xue B., Free PMC Article | 01/20/2018 |
| Wnt10a/beta-catenin signaling pathway is able to exacerbate keloid cell proliferation and inhibit the apoptosis of keloid cells through its interaction with TERT. | Wnt/β-Catenin Signaling Exacerbates Keloid Cell Proliferation by Regulating Telomerase.
Yu D, Shang Y, Yuan J, Ding S, Luo S, Hao L. | 02/18/2017 |
| WNT10A plays an important role in the pathogenesis of IPF via TGF-beta activation and it may also be a sensitive predictor for the onset of an AE-IPF. | Profibrotic role of WNT10A via TGF-β signaling in idiopathic pulmonary fibrosis.
Oda K, Yatera K, Izumi H, Ishimoto H, Yamada S, Nakao H, Hanaka T, Ogoshi T, Noguchi S, Mukae H., Free PMC Article | 11/5/2016 |
| Wnt10a regulates proliferation and apoptosis of embryonic palatal mesenchymal cells at least partially through the canonical Wnt/beta-catenin signaling pathway. | Down-regulation of Wnt10a by RNA interference inhibits proliferation and promotes apoptosis in mouse embryonic palatal mesenchymal cells through Wnt/β-catenin signaling pathway.
Feng C, Xu Z, Li Z, Zhang D, Liu Q, Lu L. | 07/19/2014 |
| Data indicate that that Wnt10a regulates Dspp expression in mesenchymal cells. | Down-regulation of Wnt10a affects odontogenesis and proliferation in mesenchymal cells.
Liu Y, Han D, Wang L, Feng H. | 08/31/2013 |
| Histone methyltransferase G9a represses adipogenesis by inhibiting PPARgamma expression and facilitating Wnt10a expression. | Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis.
Wang L, Xu S, Lee JE, Baldridge A, Grullon S, Peng W, Ge K., Free PMC Article | 03/16/2013 |
| Mechanisms downstream of beta-catenin are required for Wnt6, Wnt10a and Wnt10b to influence differentiation of mesenchymal precursors. | Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism.
Cawthorn WP, Bree AJ, Yao Y, Du B, Hemati N, Martinez-Santibañez G, MacDougald OA., Free PMC Article | 05/5/2012 |
| WNT10A may be a novel angio/stromagenic growth factor | Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway.
Yasuniwa Y, Izumi H, Wang KY, Shimajiri S, Sasaguri Y, Kawai K, Kasai H, Shimada T, Miyake K, Kashiwagi E, Hirano G, Kidani A, Akiyama M, Han B, Wu Y, Ieiri I, Higuchi S, Kohno K., Free PMC Article | 07/9/2011 |