| SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling. | SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents Myocardial Fibrosis by Paracrine Signaling.
Liu Z, Bian X, Li L, Liu L, Feng C, Wang Y, Ni J, Li S, Lu D, Li Y, Ma C, Yu T, Xiao X, Xue N, Wang Y, Zhang C, Ma X, Gao X, Fan X, Liu X, Fan G., Free PMC Article | 10/2/2024 |
| LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease. | LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
Chen W, Xu Z, Jiang J, Chen L, Chen Y, Yu T, Chen H, Shi R. | 08/7/2024 |
| SENP1 regulates intermittent hypoxia-induced microglia mediated inflammation and cognitive dysfunction via wnt/beta-catenin pathway. | SENP1 regulates intermittent hypoxia-induced microglia mediated inflammation and cognitive dysfunction via wnt/β-catenin pathway.
Ou X, Wang H, Shen Y, Zhang W, Sun J, Liu S. | 06/11/2024 |
| SENP1 attenuates hypoxia-reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF-1alpha signaling pathway. | SENP1 attenuates hypoxia‑reoxygenation injury in liver sinusoid endothelial cells by relying on the HIF‑1α signaling pathway.
Qing Z, Luo Q, Duan J, Lin J, Huang H, Yang S, Zeng Z., Free PMC Article | 03/5/2024 |
| A role and mechanism for redox sensing by SENP1 in beta-cell responses to high fat feeding. | A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding.
Lin H, Suzuki K, Smith N, Li X, Nalbach L, Fuentes S, Spigelman AF, Dai XQ, Bautista A, Ferdaoussi M, Aggarwal S, Pepper AR, Roma LP, Ampofo E, Li WH, MacDonald PE., Free PMC Article | 01/10/2024 |
| Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice. | Aberrant SUMO2/3 modification of RUNX1 upon SENP1 inhibition is linked to the development of diabetic retinopathy in mice.
Zhang W, Li F, Hou J, Cheng Y, Zhang W, Liang X, Wang J. | 11/30/2023 |
| FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation. | FSTL1 promotes alveolar epithelial cell aging and worsens pulmonary fibrosis by affecting SENP1-mediated DeSUMOylation.
Sun W, Yang X, Chen L, Guo L, Huang H, Liu X, Yang Y, Xu Z. | 09/18/2023 |
| SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway. | SENP1 modulates chronic intermittent hypoxia-induced inflammation of microglia and neuronal injury by inhibiting TOM1 pathway.
Wang H, Wang X, Shen Y, Wang Y, Yang T, Sun J, Liu S. | 06/13/2023 |
| Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis. | Transcription factor YY1 mediates self-renewal of glioblastoma stem cells through regulation of the SENP1/METTL3/MYC axis.
You J, Tao B, Peng L, Peng T, He H, Zeng S, Han J, Chen L, Xia X, Yang X, Zhong C. | 05/19/2023 |
| Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3. | Leptin accelerates BMSC transformation into vertebral epiphyseal plate chondrocytes by activating SENP1-mediated deSUMOylation of SIRT3.
Li X, Fu X, Li H, Gao Y, Wang W, Liu Z, Shen Y., Free PMC Article | 02/15/2023 |
| SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation. | SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation.
Yan L, Zhang T, Wang K, Chen Z, Yang Y, Shan B, Sun Q, Zhang M, Zhang Y, Zhong Y, Liu N, Gu J, Xu D., Free PMC Article | 11/26/2022 |
| SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling. | SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling.
Yang D, Fan D, Guo Z, Liu FY, Wang MY, An P, Yang Z, Tang QZ., Free PMC Article | 11/19/2022 |
| SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1alpha. | SENP1 protects cisplatin-induced AKI by attenuating apoptosis through regulation of HIF-1α.
Wang L, Gao X, Tang X, Xu J, Zhou J, Li L, Zou Y, Wu M, Xu L, Lin P, Yao D, Wu Q, Zhou Y, Ye C, Chen D. | 09/3/2022 |
| SENP1 regulates the transformation of lung resident mesenchymal stem cells and is associated with idiopathic pulmonary fibrosis progression. | SENP1 regulates the transformation of lung resident mesenchymal stem cells and is associated with idiopathic pulmonary fibrosis progression.
Sun W, Liu X, Yang X, Jing X, Duan C, Yang G, Wu C, Huang H, Luo Q, Xia S, Zhang Q, Yang Y, Xu Z., Free PMC Article | 07/23/2022 |
| SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice. | SENP1 in the retrosplenial agranular cortex regulates core autistic-like symptoms in mice.
Yang K, Shi Y, Du X, Wang J, Zhang Y, Shan S, Yuan Y, Wang R, Zhou C, Liu Y, Cai Z, Wang Y, Fan L, Xu H, Yu J, Cheng J, Li F, Qiu Z. | 02/19/2022 |
| SENP1 modulates microglia-mediated neuroinflammation toward intermittent hypoxia-induced cognitive decline through the de-SUMOylation of NEMO. | SENP1 modulates microglia-mediated neuroinflammation toward intermittent hypoxia-induced cognitive decline through the de-SUMOylation of NEMO.
Wang H, Yang T, Sun J, Zhang S, Liu S., Free PMC Article | 02/5/2022 |
| Role of pericyte-derived SENP1 in neuronal injury after brain ischemia. | Role of pericyte-derived SENP1 in neuronal injury after brain ischemia.
Sun M, Chen X, Yin YX, Gao Y, Zhang L, Chen B, Ji Y, Fukunaga K, Han F, Lu YM., Free PMC Article | 08/28/2021 |
| Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. | Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling.
Cai H, Bian X, Chen L, Zhang N, Li L, Tang W, Liu X, Li Z. | 08/21/2021 |
| Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development. | Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
He J, Shangguan X, Zhou W, Cao Y, Zheng Q, Tu J, Hu G, Liang Z, Jiang C, Deng L, Wang S, Yang W, Zuo Y, Ma J, Cai R, Chen Y, Fan Q, Dong B, Xue W, Tan H, Qi Y, Gu J, Su B, Eugene Chin Y, Chen G, Wang Q, Wang T, Cheng J., Free PMC Article | 08/7/2021 |
| Depletion of SENP1-mediated PPARgamma SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation. | Depletion of SENP1-mediated PPARγ SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation.
Wang H, Xiong W, Hang S, Wang Y, Zhang S, Liu S., Free PMC Article | 07/24/2021 |
| SENP1-mediated NEMO de-SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro. | SENP1-mediated NEMO de-SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro.
Yang T, Sun J, Wei B, Liu S. | 02/6/2021 |
| Findings show that increased SUMOylation of CD45 via loss of SENP1 suppresses CD45-mediated dephosphorylation of STAT3, which promotes MDSC development and function, leading to tumorigenesis | SUMO-Specific Protease 1 Is Critical for Myeloid-Derived Suppressor Cell Development and Function.
Huang X, Zuo Y, Wang X, Wu X, Tan H, Fan Q, Dong B, Xue W, Chen GQ, Cheng J. | 04/18/2020 |
| Neuronal depolarization deactivates the transcription of the SUMO protease Senp1, an important component regulating synaptic transmission, scaling, and plasticity, through Yy1. Yy1 and Senp1 promote the expression of AMPA receptor subunit GluR1, a pivotal component in learning and memory. | Yy1 regulates Senp1 contributing to AMPA receptor GluR1 expression following neuronal depolarization.
Wu T, Donohoe ME., Free PMC Article | 02/8/2020 |
| results reveal that SENP1-Sirt3 signaling modulates Sirt3 activation and mitochondrial metabolism during metabolic stress. | SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Wang T, Cao Y, Zheng Q, Tu J, Zhou W, He J, Zhong J, Chen Y, Wang J, Cai R, Zuo Y, Wei B, Fan Q, Yang J, Wu Y, Yi J, Li D, Liu M, Wang C, Zhou A, Li Y, Wu X, Yang W, Chin YE, Chen G, Cheng J. | 02/1/2020 |
| endothelial SENP1-mediated SUMOylation drives graft arteriosclerosis by regulating the synergistic effect of GATA2 and NF-kappaB and consequent endothelial dysfunction. | The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis.
Qiu C, Wang Y, Zhao H, Qin L, Shi Y, Zhu X, Song L, Zhou X, Chen J, Zhou H, Zhang H, Tellides G, Min W, Yu L., Free PMC Article | 11/24/2018 |