| Gene deletion of the PACAP/VIP receptor, VPAC2R, alters glycemic responses during metabolic and psychogenic stress in adult female mice. | Gene deletion of the PACAP/VIP receptor, VPAC2R, alters glycemic responses during metabolic and psychogenic stress in adult female mice.
Kozlova EV, Bishay AE, Denys ME, Chinthirla BD, Valdez MC, Spurgin KA, Krum JM, Basappa KR, Currás-Collazo MC. | 03/14/2024 |
| VPAC1 and VPAC2 receptor deficiencies negatively influence pregnancy outcome through distinct and overlapping modulations of immune, trophoblast and vascular functions. | VPAC1 and VPAC2 receptor deficiencies negatively influence pregnancy outcome through distinct and overlapping modulations of immune, trophoblast and vascular functions.
Calo G, Hauk V, Vota D, Van C, Condro M, Gallino L, Ramhorst R, Waschek J, Pérez Leirós C., Free PMC Article | 01/11/2023 |
| Dysfunction of VIPR2 leads to myopia in humans and mice. | Dysfunction of VIPR2 leads to myopia in humans and mice.
Zhao F, Li Q, Chen W, Zhu H, Zhou D, Reinach PS, Yang Z, He M, Xue A, Wu D, Liu T, Fu Q, Zeng C, Qu J, Zhou X. | 03/12/2022 |
| The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice. | The Circadian Clock Is Sustained in the Thyroid Gland of VIP Receptor 2 Deficient Mice.
Georg B, Fahrenkrug J, Jørgensen HL, Hannibal J., Free PMC Article | 02/19/2022 |
| The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior. | The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior.
Hamnett R, Chesham JE, Maywood ES, Hastings MH., Free PMC Article | 04/3/2021 |
| The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit. | The VIP-VPAC2 neuropeptidergic axis is a cellular pacemaking hub of the suprachiasmatic nucleus circadian circuit.
Patton AP, Edwards MD, Smyllie NJ, Hamnett R, Chesham JE, Brancaccio M, Maywood ES, Hastings MH., Free PMC Article | 09/12/2020 |
| Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling. | Spatiotemporal expression pattern of PERIOD 1 and PERIOD 2 in the mouse SCN is dependent on VIP receptor 2 signaling.
Hannibal J, Norn THB, Georg B, Fahrenkrug J. | 08/15/2020 |
| Findings suggest that the vasoactive intestinal peptide receptor 2 plays an important role in the fear extinction processes and the regulation of the dendritic morphology in the prelimbic and infralimbic cortices. | Impaired extinction of cued fear memory and abnormal dendritic morphology in the prelimbic and infralimbic cortices in VPAC2 receptor (VIPR2)-deficient mice.
Ago Y, Hayata-Takano A, Kawanai T, Yamauchi R, Takeuchi S, Cushman JD, Rajbhandari AK, Fanselow MS, Hashimoto H, Waschek JA., Free PMC Article | 07/14/2018 |
| PACAP/PAC1 signaling is important for light regulated behavior, VIP/VPAC2 signaling for stable clock function and both signaling pathways may play a role in shaping diurnality versus nocturnality. | PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice.
Hannibal J, Georg B, Fahrenkrug J., Free PMC Article | 12/23/2017 |
| Results demonstrate critical protective roles for PACAP and the VPAC2 receptor against autoimmunity, promoting the expansion and maintenance of the Treg pool. | VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses.
Tan YV, Abad C, Wang Y, Lopez R, Waschek J., Free PMC Article | 08/15/2015 |
| The results suggest that caveolin-1 plays an important role in VPAC2 receptor internalization and desensitization. | Caveolae-dependent internalization and homologous desensitization of VIP/PACAP receptor, VPAC₂, in gastrointestinal smooth muscle.
Mahavadi S, Bhattacharya S, Kim J, Fayed S, Al-Shboul O, Grider JR, Murthy KS., Free PMC Article | 08/23/2014 |
| Cumulus cells express PACAP and its receptors PAC1-R and VPAC2-R. | Expression and functional activity of PACAP and its receptors on cumulus cells: effects on oocyte maturation.
Barberi M, Di Paolo V, Latini S, Guglielmo MC, Cecconi S, Canipari R. | 02/8/2014 |
| VPAC2R mRNA expression showed a nonsignificant tendency to increase on day 7 after ischemia induced by bilateral common carotid artery occlusion. | IL-6 and PACAP receptor expression and localization after global brain ischemia in mice.
Nakamachi T, Tsuchida M, Kagami N, Yofu S, Wada Y, Hori M, Tsuchikawa D, Yoshikawa A, Imai N, Nakamura K, Arata S, Shioda S. | 04/20/2013 |
| The loss of adrenal clock gene rhythm in the VPAC2 receptor knockout mice after transfer into constant darkness was accompanied by disappearance of rhythmicity in Star mRNA expression and serum corticosterone concentration. | Altered rhythm of adrenal clock genes, StAR and serum corticosterone in VIP receptor 2-deficient mice.
Fahrenkrug J, Georg B, Hannibal J, Jørgensen HL. | 04/20/2013 |
| Cyclophosphamide-induced cystitis significantly decreased VPAC2 receptor expression in the urothelium & detrusor of both WT and NGF-OE mice | Effects of CYP-induced cystitis on PACAP/VIP and receptor expression in micturition pathways and bladder function in mice with overexpression of NGF in urothelium.
Girard BM, Tompkins JD, Parsons RL, May V, Vizzard MA., Free PMC Article | 04/20/2013 |
| The circadian clock, not ambient light level, regulates Vipr2 protein localization, since VAPC2R plays a role in signaling at all times of day. | Spatiotemporal distribution of vasoactive intestinal polypeptide receptor 2 in mouse suprachiasmatic nucleus.
An S, Tsai C, Ronecker J, Bayly A, Herzog ED., Free PMC Article | 04/13/2013 |
| Data support the notion that both VPAC1 and VPAC2 receptors are dynamically regulated by Ikaros, a master transcriptional regulator for thymocyte differentiation, during early thymic development. | Radical reversal of vasoactive intestinal peptide (VIP) receptors during early lymphopoiesis.
Vomhof-DeKrey EE, Sandy AR, Failing JJ, Hermann RJ, Hoselton SA, Schuh JM, Weldon AJ, Payne KJ, Dorsam GP., Free PMC Article | 03/31/2012 |
| results support that decline in VIP/VPAC local levels may influence survival/apoptosis intracellular set point in NOD acinar cells and their clearance, contributing to gland homeostasis loss in a model of Sjogren's syndrome | Vasoactive intestinal peptide/vasoactive intestinal peptide receptor relative expression in salivary glands as one endogenous modulator of acinar cell apoptosis in a murine model of Sjögren's syndrome.
Hauk V, Calafat M, Larocca L, Fraccaroli L, Grasso E, Ramhorst R, Leirós CP., Free PMC Article | 01/14/2012 |
| Toll-like receptor 4 and 5 stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages | Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages.
Herrera JL, Gonzalez-Rey E, Fernandez-Montesinos R, Quintana FJ, Najmanovich R, Pozo D., Free PMC Article | 12/24/2011 |
| while the main rhythm parameters of extra-SCN circadian oscillations are maintained in Vipr2(-/-) mice, the ability of these oscillators to resist phase shifts is compromised | Neuropeptide signaling differentially affects phase maintenance and rhythm generation in SCN and extra-SCN circadian oscillators.
Hughes AT, Guilding C, Piggins HD., Free PMC Article | 12/3/2011 |
| Cellular synchrony in electrical firing rates was lost in suprachiasmatic nucleus slices lacking the VPAC2 receptor for VIP. | Cyclic AMP signaling control of action potential firing rate and molecular circadian pacemaking in the suprachiasmatic nucleus.
Atkinson SE, Maywood ES, Chesham JE, Wozny C, Colwell CS, Hastings MH, Williams SR. | 10/1/2011 |
| the VIP/VPAC2 system induces reactive astrocytosis and plays a key role in neuroprotection against excitotoxicity in neurological disorders | Activation of the VIP/VPAC2 system induces reactive astrocytosis associated with increased expression of glutamate transporters.
Nishimoto M, Miyakawa H, Wada K, Furuta A. | 08/6/2011 |
| The absence of VPAC2 leads to aberrant antibody production in Aspergillus fumigatus sensitized and challenged mice | The absence of VPAC2 leads to aberrant antibody production in Aspergillus fumigatus sensitized and challenged mice.
Samarasinghe AE, Hoselton SA, Schuh JM., Free PMC Article | 07/9/2011 |
| VPAC2 signaling is necessary for a functional circadian clock driving locomotor activity, core body temperature, and heart rate rhythmicity. VPAC2-deficient mice lose the rhythms in all three parameters under constant light/darknessconditions. | Temporal phasing of locomotor activity, heart rate rhythmicity, and core body temperature is disrupted in VIP receptor 2-deficient mice.
Hannibal J, Hsiung HM, Fahrenkrug J. | 05/14/2011 |
| Data describe PACAP, vasoactive intestinal polypeptide, and PAC1, VPAC1, VPAC2 transcripts or protein expression in urothelium and detrusor smooth muscle and lumbosacral dorsal root ganglia in NGF-overexpressing and wildtype mice. | PACAP/VIP and receptor characterization in micturition pathways in mice with overexpression of NGF in urothelium.
Girard BM, Malley SE, Braas KM, May V, Vizzard MA., Free PMC Article | 04/16/2011 |