| Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42. | Rho-GEF trio regulates osteoclast differentiation and function by Rac1/Cdc42.
Gu J, Yang Z, Yuan L, Guo S, Wang D, Zhao N, Meng L, Liu H, Chen W, Ma J. | 03/13/2021 |
| distinct roles of Trio GEF domains in neurite outgrowth | Distinct functions of Trio GEF domains in axon outgrowth of cerebellar granule neurons.
Tao T, Sun J, Peng Y, Wang P, Chen X, Zhao W, Li Y, Wei L, Wang W, Zheng Y, Wang Y, Zhang X, Zhu MS. | 04/25/2020 |
| Cdh2 signaling via Trio assembles adherens junctions to restrict endothelial permeability. | N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability.
Kruse K, Lee QS, Sun Y, Klomp J, Yang X, Huang F, Sun MY, Zhao S, Hong Z, Vogel SM, Shin JW, Leckband DE, Tai LM, Malik AB, Komarova YA., Free PMC Article | 10/26/2019 |
| To study the underlying mechanism, we investigated the p38 MAPK pathway and found that loss of Trio blocked the cascade transduction of p38 MAPK signaling. In conclusion, we identified Trio as a novel coordinator in regulating root development and clarified its relevant molecular events. | The role of Rho-GEF Trio in regulating tooth root development through the p38 MAPK pathway.
Chen H, Guo S, Xia Y, Yuan L, Lu M, Zhou M, Fang M, Meng L, Xiao Z, Ma J. | 09/21/2019 |
| Trio induces RhoA activation downstream of Slit2, and support a functional role in ensuring the proper positioning of both guidepost cells and a major axonal tract. | Trio GEF mediates RhoA activation downstream of Slit2 and coordinates telencephalic wiring.
Backer S, Lokmane L, Landragin C, Deck M, Garel S, Bloch-Gallego E. | 02/16/2019 |
| Genetic damage to both TGEF domains altered TRIO catalytic activity, decreasing TGEF1 activity and increasing TGEF2 activity. | Neurodevelopmental disease-associated de novo mutations and rare sequence variants affect TRIO GDP/GTP exchange factor activity.
Katrancha SM, Wu Y, Zhu M, Eipper BA, Koleske AJ, Mains RE., Free PMC Article | 05/26/2018 |
| The Trio gene regulates the neuronal development of the hippocampus and that it affects the intelligence of adult mice. | Trio gene is required for mouse learning ability.
Zong W, Liu S, Wang X, Zhang J, Zhang T, Liu Z, Wang D, Zhang A, Zhu M, Gao J. | 12/26/2015 |
| Trio may serve as a a signal integrator decoding extrinsic signals to Rho GTPases for cytoskeleton organization | Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum.
Peng YJ, He WQ, Tang J, Tao T, Chen C, Gao YQ, Zhang WC, He XY, Dai YY, Zhu NC, Lv N, Zhang CH, Qiao YN, Zhao LP, Gao X, Zhu MS., Free PMC Article | 09/27/2010 |
| findings establish Trio as a guanine nucleotide exchange factor that mediates netrin-1 signaling in axon outgrowth and guidance through its ability to activate Rac1 | Trio mediates netrin-1-induced Rac1 activation in axon outgrowth and guidance.
Briançon-Marjollet A, Ghogha A, Nawabi H, Triki I, Auziol C, Fromont S, Piché C, Enslen H, Chebli K, Cloutier JF, Castellani V, Debant A, Lamarche-Vane N., Free PMC Article | 01/21/2010 |
| the results show a link between Trio activity,Rac1 activation,neuronal organization,and recruitment of Cadherin-11 receptor to form a complex with Trio in hindbrain embryology. | Trio controls the mature organization of neuronal clusters in the hindbrain.
Backer S, Hidalgo-Sánchez M, Offner N, Portales-Casamar E, Debant A, Fort P, Gauthier-Rouvière C, Bloch-Gallego E., Free PMC Article | 01/21/2010 |
| M-cadherin-dependent adhesion can activate Rac1 via the Rho-GEF Trio at the time of myoblast fusion. | M-cadherin activates Rac1 GTPase through the Rho-GEF trio during myoblast fusion.
Charrasse S, Comunale F, Fortier M, Portales-Casamar E, Debant A, Gauthier-Rouvière C., Free PMC Article | 01/21/2010 |