| UCP1-dependent brown adipose activation accelerates cardiac metabolic remodeling and reduces initial hypertrophic and fibrotic responses to pathological stress. | UCP1-dependent brown adipose activation accelerates cardiac metabolic remodeling and reduces initial hypertrophic and fibrotic responses to pathological stress.
Challa AA, Vidal P, Maurya SK, Maurya CK, Baer LA, Wang Y, James NM, Pardeshi PJ, Fasano M, Carley AN, Stanford KI, Lewandowski ED., | 09/19/2024 |
| Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse UCP1. | Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse UCP1.
Musiol E, Fromme T, Hau J, Di Pizio A, Klingenspor M. | 08/20/2024 |
| Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis. | Decrease in UCP1 by sustained high lipid promotes NK cell necroptosis to exacerbate nonalcoholic liver fibrosis.
Gu M, Zhang Y, Lin Z, Hu X, Zhu Y, Xiao W, Jia X, Chen W, Lu G, Gong W., Free PMC Article | 08/6/2024 |
| Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity. | Mitochondrial lipidomes are tissue specific - low cholesterol contents relate to UCP1 activity.
Brunner S, Höring M, Liebisch G, Schweizer S, Scheiber J, Giansanti P, Hidrobo M, Hermeling S, Oeckl J, Prudente de Mello N, Perocchi F, Seeliger C, Strohmeyer A, Klingenspor M, Plagge J, Küster B, Burkhardt R, Janssen KP, Ecker J., Free PMC Article | 06/14/2024 |
| Differential responses to UCP1 ablation in classical brown versus beige fat, despite a parallel increase in sympathetic innervation. | Differential responses to UCP1 ablation in classical brown versus beige fat, despite a parallel increase in sympathetic innervation.
Naren Q, Lindsund E, Bokhari MH, Pang W, Petrovic N., Free PMC Article | 04/16/2024 |
| Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning. | Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning.
Peixoto ÁS, Moreno MF, Castro É, Perandini LA, Belchior T, Oliveira TE, Vieira TS, Gilio GR, Tomazelli CA, Leonardi BF, Ortiz-Silva M, Silva Junior LP, Moretti EH, Steiner AA, Festuccia WT. | 03/21/2024 |
| Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB. | Parallel control of cold-triggered adipocyte thermogenesis by UCP1 and CKB.
Rahbani JF, Bunk J, Lagarde D, Samborska B, Roesler A, Xiao H, Shaw A, Kaiser Z, Braun JL, Geromella MS, Fajardo VA, Koza RA, Kazak L. | 03/11/2024 |
| Suppression of STAT3 phosphorylation in hypothalamus facilitates weight loss via upregulating UCP1. | Suppression of STAT3 phosphorylation in hypothalamus facilitates weight loss via upregulating UCP1.
Xu L, Li H, Wang K, Yang G. | 12/26/2023 |
| PPARalpha/gamma synergism activates UCP1-dependent and -independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice. | PPARα/γ synergism activates UCP1-dependent and -independent thermogenesis and improves mitochondrial dynamics in the beige adipocytes of high-fat fed mice.
Miranda CS, Silva-Veiga FM, Santana-Oliveira DA, Vasques-Monteiro IML, Daleprane JB, Souza-Mello V. | 12/16/2023 |
| Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice. | Wnt10b knockdown promotes UCP1 expression in brown adipose tissue in mice.
Jia Y, Liu Y, Liu S, Chang Y, Xu L, Li H. | 11/15/2023 |
| HDAC1 inhibits beige adipocyte-mediated thermogenesis through histone crotonylation of Pgc1a/Ucp1. | HDAC1 inhibits beige adipocyte-mediated thermogenesis through histone crotonylation of Pgc1a/Ucp1.
Tian D, Zeng X, Gong Y, Zheng Y, Zhang J, Wu Z. | 10/10/2023 |
| Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1. | Proline hydroxylase 2 (PHD2) promotes brown adipose thermogenesis by enhancing the hydroxylation of UCP1.
Li F, Zhang F, Yi X, Quan LL, Yang X, Yin C, Ma Z, Wu R, Zhao W, Ling M, Lang L, Hussein A, Feng S, Fu Y, Wang J, Liang S, Zhu C, Wang L, Zhu X, Gao P, Xi Q, Zhang Y, Zhang L, Shu G, Jiang Q, Wang S., Free PMC Article | 06/29/2023 |
| Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21. | Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21.
Klein Hazebroek M, Laterveer R, Kutschke M, Ramšak Marčeta V, Barthem CS, Keipert S., Free PMC Article | 06/26/2023 |
| Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells. | Dopamine receptor D4 (DRD4) negatively regulates UCP1- and ATP-dependent thermogenesis in 3T3-L1 adipocytes and C2C12 muscle cells.
Haddish K, Yun JW. | 05/17/2023 |
| Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis. | Selective deficiency of UCP-1 and adropin may lead to different subtypes of anti-neutrophil cytoplasmic antibody-associated vasculitis.
Chen Q, Li Y, Guo X, Liu Y, Guo Y, Lv X, Lin Y, Liu Q. | 02/24/2023 |
| Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer's Disease-Related Pathologies. | Deletion of UCP1 in Tg2576 Mice Increases Body Temperature and Exacerbates Alzheimer's Disease-Related Pathologies.
Jung CG, Yamashita H, Kato R, Zhou C, Matsushita H, Takeuchi T, Abdelhamid M, Chen Y, Michikawa M., Free PMC Article | 02/16/2023 |
| Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a Temperature-Dependent Manner. | Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a Temperature-Dependent Manner.
Sideromenos S, Gundacker A, Nikou M, Oberle R, Horvath O, Stoehrmann P, Partonen T, Pollak DD., Free PMC Article | 01/28/2023 |
| Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle. | Decreased methylglyoxal-mediated protein glycation in the healthy aging mouse model of ectopic expression of UCP1 in skeletal muscle.
Masania J, Wijten P, Keipert S, Ost M, Klaus S, Rabbani N, Thornalley PJ., Free PMC Article | 01/28/2023 |
| Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue. | Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue.
Klein Hazebroek M, Keipert S., Free PMC Article | 09/3/2022 |
| Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. | Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat.
Oeckl J, Janovska P, Adamcova K, Bardova K, Brunner S, Dieckmann S, Ecker J, Fromme T, Funda J, Gantert T, Giansanti P, Hidrobo MS, Kuda O, Kuster B, Li Y, Pohl R, Schmitt S, Schweizer S, Zischka H, Zouhar P, Kopecky J, Klingenspor M., Free PMC Article | 06/18/2022 |
| AMP-activated protein kinase activation in skeletal muscle modulates exercise-induced uncoupled protein 1 expression in brown adipocyte in mouse model. | AMP-activated protein kinase activation in skeletal muscle modulates exercise-induced uncoupled protein 1 expression in brown adipocyte in mouse model.
Kim HJ, Kim YJ, Seong JK., Free PMC Article | 05/21/2022 |
| Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis. | Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis.
Saijo S, Ohno M, Iwasaki H, Matsuda S, Nishi K, Hiraoka Y, Ide N, Kimura T, Nishi E., Free PMC Article | 04/23/2022 |
| Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. | Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET., Free PMC Article | 04/23/2022 |
| A pyrexic effect of FGF21 independent of energy expenditure and UCP1. | A pyrexic effect of FGF21 independent of energy expenditure and UCP1.
Zouhar P, Janovska P, Stanic S, Bardova K, Funda J, Haberlova B, Andersen B, Rossmeisl M, Cannon B, Kopecky J, Nedergaard J., Free PMC Article | 03/26/2022 |
| Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality. | Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality.
McKie GL, Medak KD, Shamshoum H, Wright DC. | 03/5/2022 |