| Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-beta/Smad Signalling Pathway in Fibroblasts. | Inhibition of Ubiquitin C-Terminal Hydrolase L1 Facilitates Cutaneous Wound Healing via Activating TGF-β/Smad Signalling Pathway in Fibroblasts.
Pan H, Song J, An Q, Chen J, Zheng W, Zhang L, Gu J, Deng C, Yang B. | 10/16/2024 |
| Skeletal Muscle UCHL1 Negatively Regulates Muscle Development and Recovery after Muscle Injury. | Skeletal Muscle UCHL1 Negatively Regulates Muscle Development and Recovery after Muscle Injury.
Antony R, Aby K, Montgomery M, Li Y., Free PMC Article | 07/18/2024 |
| A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver. | A novel proteomic signature of osteoclast differentiation unveils the deubiquitinase UCHL1 as a necessary osteoclastogenic driver.
Materozzi M, Resnati M, Facchi C, Trudu M, Orfanelli U, Perini T, Gennari L, Milan E, Cenci S., Free PMC Article | 04/1/2024 |
| Deubiquitinase UCHL1 promotes angiogenesis and blood-spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17. | Deubiquitinase UCHL1 promotes angiogenesis and blood-spinal cord barrier function recovery after spinal cord injury by stabilizing Sox17.
Wang J, Ji C, Ye W, Rong Y, Ge X, Wang Z, Tang P, Zhou Z, Luo Y, Cai W., Free PMC Article | 03/15/2024 |
| UCHL1 deficiency upon HCMV infection induces vascular endothelial inflammatory injury mediated by mitochondrial iron overload. | UCHL1 deficiency upon HCMV infection induces vascular endothelial inflammatory injury mediated by mitochondrial iron overload.
Zhu W, Zhu W, Wang S, Liu S, Zhang H. | 01/11/2024 |
| UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1. | UCHL1 Regulates Radiation Lung Injury via Sphingosine Kinase-1.
Epshtein Y, Mathew B, Chen W, Jacobson JR., Free PMC Article | 11/2/2023 |
| The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling. | The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling.
Feng Z, Tao S, Huang Z, Zheng B, Kong X, Xiang Y, Zhang Q, Song H, Xu Z, Wei X, Zhao F, Chen J., Free PMC Article | 05/30/2023 |
| Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis. | Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis.
Reichelt J, Sachs W, Frömbling S, Fehlert J, Studencka-Turski M, Betz A, Loreth D, Blume L, Witt S, Pohl S, Brand J, Czesla M, Knop J, Florea BI, Zielinski S, Sachs M, Hoxha E, Hermans-Borgmeyer I, Zahner G, Wiech T, Krüger E, Meyer-Schwesinger C., Free PMC Article | 04/17/2023 |
| Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury. | Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury.
Mi Z, Graham SH., Free PMC Article | 03/8/2023 |
| UCHL1 Impairs Periodontal Ligament Stem Cell Osteogenesis in Periodontitis. | UCHL1 Impairs Periodontal Ligament Stem Cell Osteogenesis in Periodontitis.
Lin L, Li S, Hu S, Yu W, Jiang B, Mao C, Li G, Yang R, Miao X, Jin M, Gu Y, Lu E. | 12/31/2022 |
| Structural basis for specific inhibition of the deubiquitinase UCHL1. | Structural basis for specific inhibition of the deubiquitinase UCHL1.
Grethe C, Schmidt M, Kipka GM, O'Dea R, Gallant K, Janning P, Gersch M., Free PMC Article | 10/22/2022 |
| The requirement of ubiquitin C-terminal hydrolase L1 in mouse ovarian development and fertilitydagger. | The requirement of ubiquitin C-terminal hydrolase L1 in mouse ovarian development and fertility†.
Woodman MF, Ozcan MCH, Gura MA, De La Cruz P, Gadson AK, Grive KJ., Free PMC Article | 08/27/2022 |
| UCHL1 regulates inflammation via MAPK and NF-kappaB pathways in LPS-activated macrophages. | UCHL1 regulates inflammation via MAPK and NF-κB pathways in LPS-activated macrophages.
Zhang Z, Liu N, Chen X, Zhang F, Kong T, Tang X, Yang Q, Chen W, Xiong X, Chen X. | 01/22/2022 |
| Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells. | Loss of Ubiquitin Carboxy-Terminal Hydrolase L1 Impairs Long-Term Differentiation Competence and Metabolic Regulation in Murine Spermatogonial Stem Cells.
Alpaugh WF, Voigt AL, Dardari R, Su L, Al Khatib I, Shin W, Goldsmith TM, Coyle KM, Tang LA, Shutt TE, Klein C, Biernaskie J, Dobrinski I., Free PMC Article | 11/22/2021 |
| Mutation of a Ubiquitin Carboxy Terminal Hydrolase L1 Lipid Binding Site Alleviates Cell Death, Axonal Injury, and Behavioral Deficits After Traumatic Brain Injury in Mice. | Mutation of a Ubiquitin Carboxy Terminal Hydrolase L1 Lipid Binding Site Alleviates Cell Death, Axonal Injury, and Behavioral Deficits After Traumatic Brain Injury in Mice.
Mi Z, Liu H, Rose ME, Ma J, Reay DP, Ma X, Henchir JJ, Dixon CE, Graham SH., Free PMC Article | 10/30/2021 |
| Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice. | Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.
Mi Z, Liu H, Rose ME, Ma X, Reay DP, Ma J, Henchir J, Dixon CE, Graham SH., Free PMC Article | 09/4/2021 |
| UCHL1, a deubiquitinating enzyme, regulates lung endothelial cell permeability in vitro and in vivo. | UCHL1, a deubiquitinating enzyme, regulates lung endothelial cell permeability in vitro and in vivo.
Mitra S, Epshtein Y, Sammani S, Quijada H, Chen W, Bandela M, Desai AA, Garcia JGN, Jacobson JR., Free PMC Article | 05/15/2021 |
| Deubiquitination of CD36 by UCHL1 promotes foam cell formation. | Deubiquitination of CD36 by UCHL1 promotes foam cell formation.
Xia X, Xu Q, Liu M, Chen X, Liu X, He J, Hu T, Yu C, Huang H, Liu S, Liu N., Free PMC Article | 04/17/2021 |
| UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression. | UCH-L1 inhibitor LDN-57444 hampers mouse oocyte maturation by regulating oxidative stress and mitochondrial function and reducing ERK1/2 expression.
Yuan P, Zhou L, Zhang X, Yao L, Ning J, Han X, Ming C, Zhao Y, Zhang L., Free PMC Article | 04/17/2021 |
| Gene UCHL1 expresses specifically in mouse uterine decidual cells in response to estrogen. | Gene UCHL1 expresses specifically in mouse uterine decidual cells in response to estrogen.
Hao L, Song D, Zhuang M, Shi Y, Yu L, He Y, Wang J, Zhang T, Sun Z. | 01/2/2021 |
| Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78). | Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Lei Q, Yi T, Li H, Yan Z, Lv Z, Li G, Wang Y., Free PMC Article | 12/19/2020 |
| These results demonstrate a hitherto unrecognized role of the deubiquitinating enzyme UCH-L1 in DC Ag processing. | Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules.
Reinicke AT, Raczkowski F, Mühlig M, Schmucker P, Lischke T, Reichelt J, Schneider E, Zielinski S, Sachs M, Jurack E, Tolosa E, Kurts C, Mittrücker HW, Meyer-Schwesinger C. | 05/23/2020 |
| UCHL1 activity is an important determinant of function after ischemia and further demonstrate that the C152 site of UCHL1 plays a significant role in functional recovery after stroke. | Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia.
Liu H, Povysheva N, Rose ME, Mi Z, Banton JS, Li W, Chen F, Reay DP, Barrionuevo G, Zhang F, Graham SH., Free PMC Article | 04/4/2020 |
| Study in mouse model of traumatic brain injury (TBI) after polytrauma demonstrates that UCH-L1 is not a specific marker for TBI but is elevated in models that induce central and peripheral nerve ischemia. Results suggest that UCH-L1 may be a useful adjunct in quantifying severity of shock or global ischemia rather than as a specific marker of TBI. | UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma.
Morris MC, Bercz A, Niziolek GM, Kassam F, Veile R, Friend LA, Pritts TA, Makley AT, Goodman MD., Free PMC Article | 02/15/2020 |
| study demonstrates a novel role of UCHL1 in regulating the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells, which further affects their immunotherapy for inflammatory diseases. | The deubiquitinating enzyme UCHL1 negatively regulates the immunosuppressive capacity and survival of multipotent mesenchymal stromal cells.
Gu Y, Ding X, Huang J, Xue M, Zhang J, Wang Q, Yu H, Wang Y, Zhao F, Wang H, Jin M, Wu Y, Zhang Y., Free PMC Article | 11/9/2019 |