| Increased expression of ficolin-1 is associated with airway obstruction in asthma. | Increased expression of ficolin-1 is associated with airway obstruction in asthma.
Gao P, Tang K, Lu Y, Wang M, Wang W, Wang T, Sun Y, Zhao J, Mao Y., Free PMC Article | 12/1/2023 |
| Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients. | Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients.
Moulana Z, Bagherzadeh M, Mirzakhani M, Rostami A, Mohammadnia-Afrouzi M, Shahbazi M., Free PMC Article | 12/3/2022 |
| M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis. | M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis.
Brix N, Glerup M, Thiel S, Mistegaard CE, Skals RG, Berntson L, Fasth A, Nielsen SM, Nordal E, Rygg M, Hasle H, Albertsen BK, Herlin T, Nordic Study Group of Pediatric Rheumatology (NoSPeR) group., Free PMC Article | 04/23/2022 |
| FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study. | FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study.
Olszowski T, Milona M, Janiszewska-Olszowska J, Safranow K, Uzar I, Walczak A, Sikora M, Chlubek D, Adler G. | 03/12/2022 |
| Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population. | Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population.
Li Y, You EQ, Lin WH, Liu XN, Shen DP, Zhang XL, Ma DC, Li HM., Free PMC Article | 11/13/2021 |
| Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults. | Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults.
Sokołowska A, Świerzko AS, Gajek G, Gołos A, Michalski M, Nowicki M, Szala-Poździej A, Wolska-Washer A, Brzezińska O, Wierzbowska A, Jamroziak K, Kowalski ML, Thiel S, Matsushita M, Jensenius JC, Cedzyński M., Free PMC Article | 01/16/2021 |
| Association between serum ficolin-1 level and disease progression in primary biliary cholangitis. | Association between serum ficolin-1 level and disease progression in primary biliary cholangitis.
Hayashi M, Abe K, Fujita M, Takahashi A, Sekine H, Ohira H., Free PMC Article | 10/31/2020 |
| Ficolin-1 gene (FCN1) -144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under-five Egyptian children: A multicenter study. | Ficolin-1 gene (FCN1) -144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under-five Egyptian children: A multicenter study.
Elkoumi MA, Abdellatif SH, Mohamed FY, Sherif AH, Elashkar SSA, Saleh RM, Boraey NF, Abdelaal NM, Akeel NE, Elhewala AA, Mosbah AA, Zakaria MT, Soliman MM, Salah A, Sedky YM, Sobieh AA, Mashali MH, Waked NM, Elshreif AM, Hafez SF, Hashem MIA, Shehab MM, Soliman AA, Emam AA, Ahmed AAA, Fahim MS, Elshehawy NA, Abdel-Aziz MM, Abdou AM, El-Shehawy AA, Youssef MAA, Fahmy DS, Malek MM, Osman SF, Ibrahim MAM, Alanwar MI, Zeidan NMS. | 10/24/2020 |
| Study of FCN1 promoter polymorphisms in rheumatic fever (RF) and rheumatic heart disease (RHD) patient revealed that minor FCN1 promoter variants may play a protective role against RF, by encouraging bacteria elimination as well as increasing gene expression and protein levels. On the other hand, they may also predispose the patients to RHD symptoms thus emphasizing the dual importance of ficolin-1 in both conditions. | Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever.
Catarino SJ, Andrade FA, Boldt ABW, Guilherme L, Messias-Reason IJ., Free PMC Article | 11/30/2019 |
| There is a strong association between serum levels of PTX3, M-ficolin, and SPA with the severity of ischemic stroke. Clinically, such association may be considered to evaluate the severity of the ischemic stroke. | Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke.
Kouchaki E, Babamohammadi A, Nikoueinejad H, Sehat M. | 07/6/2019 |
| These results suggest that FCN1 is a molecular target of intravenous IVIG in KD patients. We propose that these peptides and a humanized monoclonal antibody against FCN1 could be useful in combination therapy with IVIG. | FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease.
Okuzaki D, Ota K, Takatsuki SI, Akiyoshi Y, Naoi K, Yabuta N, Saji T, Nojima H., Free PMC Article | 06/22/2019 |
| M-ficolin interacts with A. fumigatus through interaction with chitin and beta-1,3 glucan and thereby mediates complement activation and potentiates IL-8 secretion of A549 cells. | M-ficolin is present in Aspergillus fumigatus infected lung and modulates epithelial cell immune responses elicited by fungal cell wall polysaccharides.
Jensen K, Lund KP, Christensen KB, Holm AT, Dubey LK, Moeller JB, Jepsen CS, Schlosser A, Galgóczy L, Thiel S, Holmskov U, Sorensen GL., Free PMC Article | 10/13/2018 |
| higher ficolin-1 levels were associated with brain ischemic lesions and vasospasm following subarachnoid hemorrhage. | Ficolin-1 Levels in Patients Developing Vasospasm and Cerebral Ischemia After Spontaneous Subarachnoid Hemorrhage.
Llull L, Thiel S, Amaro S, Cervera Á, Planas AM, Chamorro Á. | 07/14/2018 |
| in northeastern Brazilian children and adolescents, FCN1 rs1071583 SNP was correlated with earlier age of type 1 diabetes mellitus (T1D) diagnosis; the SNP combination rs2989727 and rs1071583 was involved with T1D protection | Polymorphism in ficolin-1 (FCN1) gene is associated with an earlier onset of type 1 diabetes mellitus in children and adolescents from northeast Brazil.
Anjosa ZP, Santos MM, Rodrigues NJ, Lacerda GA, Araujo J, Silva JA, Tavares NA, Guimarães RL, Crovella S, Brandão LA. | 06/10/2017 |
| Ficolin-1 could provide an alternative receptor-mediated mechanism for enhancing Ebola Virus infection, thereby contributing to viral subversion of the host innate immune system. | Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.
Favier AL, Gout E, Reynard O, Ferraris O, Kleman JP, Volchkov V, Peyrefitte C, Thielens NM., Free PMC Article | 04/29/2017 |
| systemic lupus erythematosus patients with high ficolin-1 plasma levels had an increased risk of end-stage renal disease; there was no significant association between ficolin-1 and ficolin-3 with lupus nephritis | Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus.
Tanha N, Pilely K, Faurschou M, Garred P, Jacobsen S. | 04/15/2017 |
| Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 mug/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher | Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke.
Zangari R, Zanier ER, Torgano G, Bersano A, Beretta S, Beghi E, Casolla B, Checcarelli N, Lanfranconi S, Maino A, Mandelli C, Micieli G, Orzi F, Picetti E, Silvestrini M, Stocchetti N, Zecca B, Garred P, De Simoni MG, LEPAS group., Free PMC Article | 10/8/2016 |
| Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls. | Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus.
Troldborg A, Thiel S, Jensen L, Hansen S, Laska MJ, Deleuran B, Jensenius JC, Stengaard-Pedersen K., Free PMC Article | 03/19/2016 |
| This study aims to investigate whether an association exists between the ficolins that are part of the lectin complement pathway and systemic lupus erythematosus. | Ficolins and the lectin pathway of complement in patients with systemic lupus erythematosus.
Hein E, Nielsen LA, Nielsen CT, Munthe-Fog L, Skjoedt MO, Jacobsen S, Garred P. | 03/7/2015 |
| the differential binding of ficolin-1 to lymphocyte subsets suggests ficolin-1 as a novel link between innate and adaptive immunity. | The pattern recognition molecule ficolin-1 exhibits differential binding to lymphocyte subsets, providing a novel link between innate and adaptive immunity.
Genster N, Ma YJ, Munthe-Fog L, Garred P. | 02/15/2014 |
| In patients with early rheumatoid arthritis, elevated plasma M-ficolin levels correlated with a high disease activity score at baseline and 1 year. A low M-ficolin level was the strongest predictor of remission and low disease activity. | M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis.
Ammitzbøll CG, Thiel S, Jensenius JC, Ellingsen T, Hørslev-Petersen K, Hetland ML, Junker P, Krogh NS, Østergaard M, Stengaard-Pedersen K. | 02/1/2014 |
| Data show that a photodynamic therapy (PDT) dose-dependent upregulation of CRP gene, as well as of PTX3 and ficolin 1 genes in lung tumor A549 cells, and indicate critical role played by PI3K/Akt/AP-1 pathway. | Upregulation of genes for C-reactive protein and related pentraxin/complement proteins in photodynamic therapy-treated human tumor cells: enrolment of PI3K/Akt and AP-1.
Merchant S, Korbelik M. | 11/2/2013 |
| These results demonstrate that ficolin-1 and PTX3 heterocomplex formation acts as a noninflammatory "find me and eat me" signal to sequester altered-host cells. | Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production.
Ma YJ, Doni A, Romani L, Jürgensen HJ, Behrendt N, Mantovani A, Garred P. | 10/19/2013 |
| M-ficolin bound strongly to serotype 19B and 19C polysaccharides. | M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a Streptococcus mitis strain.
Kjaer TR, Hansen AG, Sørensen UB, Holm AT, Sørensen GL, Jensenius JC, Thiel S., Free PMC Article | 06/8/2013 |
| Study interlinks the genotype and phenotype relationship concerning polymorphisms in FCN1 and corresponding concentrations and biological functions of M-ficolin. | Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin.
Ammitzbøll CG, Kjær TR, Steffensen R, Stengaard-Pedersen K, Nielsen HJ, Thiel S, Bøgsted M, Jensenius JC., Free PMC Article | 05/25/2013 |