| CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis. | CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.
Yi M, Lv S, He Y, Wu Y, Zhang J, Chen Q. | 07/10/2023 |
| Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming through inducing pluripotent gene expression and promoting cell proliferation. | Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming through inducing pluripotent gene expression and promoting cell proliferation.
Hou C, Ye Z, Yang S, Jiang Z, Wang J, Wang E. | 10/8/2022 |
| The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update. | The Role of LSD1 and LSD2 in Cancers of the Gastrointestinal System: An Update.
Malagraba G, Yarmohammadi M, Javed A, Barceló C, Rubio-Tomás T., Free PMC Article | 05/7/2022 |
| Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage. | Histone demethylase AMX-1 is necessary for proper sensitivity to interstrand crosslink DNA damage.
Zhang X, Tian S, Beese-Sims SE, Chen J, Shin N, Colaiácovo MP, Kim HM., Free PMC Article | 11/13/2021 |
| In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study. | In vitro evidence of NLRP3 inflammasome regulation by histone demethylase LSD2 in renal cancer: a pilot study.
Kumar A, Nallabelli N, Sharma U, Kumari N, Singh SK, Kakkar N, Prasad R. | 05/22/2021 |
| [Expression and Clinical Significance of MiR-215 and KDM1B in Patients with Diffuse Large B Cell Lymphoma]. | [Expression and Clinical Significance of MiR-215 and KDM1B in Patients with Diffuse Large B Cell Lymphoma].
Wu RJ, Zou Y, Ma XD, Zheng RJ. | 10/24/2020 |
| Reduction in H3K4me patterns due to aberrant expression of methyltransferases and demethylases in renal cell carcinoma: prognostic and therapeutic implications. | Reduction in H3K4me patterns due to aberrant expression of methyltransferases and demethylases in renal cell carcinoma: prognostic and therapeutic implications.
Kumar A, Kumari N, Sharma U, Ram S, Singh SK, Kakkar N, Kaushal K, Prasad R., Free PMC Article | 10/24/2020 |
| While LSD1/CoREST forms a nucleosome docking platform at silenced gene promoters, LSD2/NPAC is a multifunctional enzyme complex with flexible linkers, tailored for rapid chromatin modification, in conjunction with the advance of the RNA polymerase on actively transcribed genes. | A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex.
Marabelli C, Marrocco B, Pilotto S, Chittori S, Picaud S, Marchese S, Ciossani G, Forneris F, Filippakopoulos P, Schoehn G, Rhodes D, Subramaniam S, Mattevi A. | 06/27/2020 |
| The expression of LSD2 was associated with higher TNM stage and metastasis of the tumor and thus, might serve as a useful marker for Clear cell renal cell carcinoma (ccRCC) progression. | Expression profile of H3K4 demethylases with their clinical and pathological correlation in patients with clear cell renal cell carcinoma.
Kumar A, Kumari N, Nallabelli N, Sharma U, Rai A, Singh SK, Kakkar N, Prasad R. | 04/18/2020 |
| our findings provided new insights into the critical and multifaceted roles of KDM1B in the regulation of cell proliferation and apoptosis, and offered a potentially novel target in preventing the progression of pancreatic cancer. | Knockdown of KDM1B inhibits cell proliferation and induces apoptosis of pancreatic cancer cells.
Wang Y, Sun L, Luo Y, He S. | 08/31/2019 |
| These results suggest that LSD2 achieves a promoting effect on small cell lung cancer by indirectly regulating TFPI2 expression through the mediation of DNMT3B expression or through the regulation of the demethylation of H3K4me1 in the promoter region of the TFPI2 gene. | Lysine‑specific demethylase 2 contributes to the proliferation of small cell lung cancer by regulating the expression of TFPI‑2.
Cao Y, Guo C, Yin Y, Li X, Zhou L., Free PMC Article | 10/20/2018 |
| This review focuses on published small-molecule inhibitors targeted at the two flavin adenine dinucleotide-dependent lysine demethylases, lysine-specific demethylases 1 and 2, and how the inhibitors interact with the tertiary structures of the enzymes. | Structural insight into inhibitors of flavin adenine dinucleotide-dependent lysine demethylases.
Niwa H, Umehara T., Free PMC Article | 07/8/2017 |
| These results demonstrate an important role for LSD2 in regulation of DNA methylation and gene silencing in breast cancer. | Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.
Katz TA, Vasilatos SN, Harrington E, Oesterreich S, Davidson NE, Huang Y. | 08/22/2015 |
| Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT. | Histone demethylase LSD2 acts as an E3 ubiquitin ligase and inhibits cancer cell growth through promoting proteasomal degradation of OGT.
Yang Y, Yin X, Yang H, Xu Y. | 06/20/2015 |
| Using transcriptome and chromatin immunoprecipitation-sequencing analyses, the study revealed that LSD2 represses the genes involved in lipid influx and metabolism through demethylation of histone H3K4. | Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.
Nagaoka K, Hino S, Sakamoto A, Anan K, Takase R, Umehara T, Yokoyama S, Sasaki Y, Nakao M., Free PMC Article | 05/30/2015 |
| regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 | Regulation of tissue factor pathway inhibitor-2 (TFPI-2) expression by lysine-specific demethylase 1 and 2 (LSD1 and LSD2).
Mino K, Nishimura S, Ninomiya S, Tujii H, Matsumori Y, Tsuchida M, Hosoi M, Koseki K, Wada S, Hasegawa M, Sasaki R, Murakami-Yamaguchi Y, Narita H, Suzuki T, Miyata N, Mizukami T. | 04/4/2015 |
| The zinc finger-SWIRM-oxidase domains is required for KDM1B demethylase activity and the binding of FAD. | Structure-function analysis reveals a novel mechanism for regulation of histone demethylase LSD2/AOF1/KDM1b.
Zhang Q, Qi S, Xu M, Yu L, Tao Y, Deng Z, Wu W, Li J, Chen Z, Wong J., Free PMC Article | 08/31/2013 |
| Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. | Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation.
Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi Y, Shi YG., Free PMC Article | 08/23/2010 |