| Thyroid stimulating hormone beta-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection. | Thyroid stimulating hormone β-subunit splice variant is expressed in all fractional subsets of bone marrow hematopoietic cells and peripheral blood leukocytes and is modulated during bacterial infection.
Weber A, Pawar HN, Klein JR., Free PMC Article | 12/19/2020 |
| TSH, as an independent risk factor of atherosclerosis, aggravates vascular inflammation and contributes to atherogenesis. | Thyrotropin aggravates atherosclerosis by promoting macrophage inflammation in plaques.
Yang C, Lu M, Chen W, He Z, Hou X, Feng M, Zhang H, Bo T, Zhou X, Yu Y, Zhang H, Zhao M, Wang L, Yu C, Gao L, Jiang W, Zhang Q, Zhao J., Free PMC Article | 05/9/2020 |
| subcutaneous adipose tissue Tshb expression levels correlated directly with circulating cholesterol levels | TSHB mRNA is linked to cholesterol metabolism in adipose tissue.
Moreno-Navarrete JM, Moreno M, Ortega F, Xifra G, Hong S, Asara JM, Serrano JCE, Jové M, Pissios P, Blüher M, Ricart W, Portero-Otin M, Fernández-Real JM., Free PMC Article | 10/21/2017 |
| Oncogene-induced senescence is initiated in Braf(V600E)-induced papillary thyroid cancers when TSH is normal. TSH reduces p53 expression by upregulating the PI3K/AKT pathway and inhibiting OIS, resulting in tumor progression. | TSH overcomes Braf(V600E)-induced senescence to promote tumor progression via downregulation of p53 expression in papillary thyroid cancer.
Zou M, Baitei EY, Al-Rijjal RA, Parhar RS, Al-Mohanna FA, Kimura S, Pritchard C, Binessa HA, Alzahrani AS, Al-Khalaf HH, Hawwari A, Akhtar M, Assiri AM, Meyer BF, Shi Y., Free PMC Article | 09/3/2016 |
| The observations indicate that the experimental system possesses responsiveness of the TSHbeta expression to melatonin. | Establishment of TSH β real-time monitoring system in mammalian photoperiodism.
Tsujino K, Narumi R, Masumoto KH, Susaki EA, Shinohara Y, Abe T, Iigo M, Wada A, Nagano M, Shigeyoshi Y, Ueda HR., Free PMC Article | 10/11/2014 |
| PPARalpha modulates the TSH beta-subunit mRNA expression in thyrotrope cells. | PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model.
Wege N, Schutkowski A, König B, Brandsch C, Weiwad M, Stangl GI. | 12/28/2013 |
| Tshb gene transcription was attenuated in MED1 mutant mice in which the nuclear receptor-binding ability of MED1 was specifically disrupted. | Mediator subunit MED1 is a T3-dependent and T3-independent coactivator on the thyrotropin β gene promoter.
Matsui K, Oda K, Mizuta S, Ishino R, Urahama N, Hasegawa N, Roeder RG, Ito M., Free PMC Article | 12/7/2013 |
| Disruption of type II deiodinase in thyrotrophs decreases their sensitivity to T4 thyroid hormone and thus elevates serum TSH. | Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
Fonseca TL, Correa-Medina M, Campos MP, Wittmann G, Werneck-de-Castro JP, Arrojo e Drigo R, Mora-Garzon M, Ueta CB, Caicedo A, Fekete C, Gereben B, Lechan RM, Bianco AC., Free PMC Article | 05/25/2013 |
| Thyrotropin-releasing hormone altered the basal expression of the TSHbeta gene and the responsiveness of the gene to thyroid hormone. | NR4A1 (Nur77) mediates thyrotropin-releasing hormone-induced stimulation of transcription of the thyrotropin β gene: analysis of TRH knockout mice.
Nakajima Y, Yamada M, Taguchi R, Shibusawa N, Ozawa A, Tomaru T, Hashimoto K, Saito T, Tsuchiya T, Okada S, Satoh T, Mori M., Free PMC Article | 04/6/2013 |
| PBF is the first protein to interact with the critical TH transporter MCT8 and modulate its function in vivo | PTTG-binding factor (PBF) is a novel regulator of the thyroid hormone transporter MCT8.
Smith VE, Read ML, Turnell AS, Sharma N, Lewy GD, Fong JC, Seed RI, Kwan P, Ryan G, Mehanna H, Chan SY, Darras VM, Boelaert K, Franklyn JA, McCabe CJ. | 09/22/2012 |
| thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies have roles in osteoclastogenesis | The influence of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on osteoclastogenesis.
Ma R, Morshed S, Latif R, Zaidi M, Davies TF., Free PMC Article | 01/14/2012 |
| Data demonstrate that Eya3 and its partner Six1 synergistically activate TSHbeta expression and that this activation is further enhanced by Tef and Hlf. | Acute induction of Eya3 by late-night light stimulation triggers TSHβ expression in photoperiodism.
Masumoto KH, Ukai-Tadenuma M, Kasukawa T, Nagano M, Uno KD, Tsujino K, Horikawa K, Shigeyoshi Y, Ueda HR. | 04/9/2011 |
| Data show that the -588/-560 region of nuclear factor I is involved in the insulin-mediated repression of thyroid stimulating hormone beta. | Insulin represses transcription of the thyroid stimulating hormone beta-subunit gene through increased recruitment of nuclear factor I.
Kim KK, Park KS, Song SB, Kim KE., Free PMC Article | 12/11/2010 |
| expression in the pars tuberalis controlled by melatonin and the molecular clockwork | Impact of melatonin and molecular clockwork components on the expression of thyrotropin beta-chain (Tshb) and the Tsh receptor in the mouse pars tuberalis.
Unfried C, Ansari N, Yasuo S, Korf HW, von Gall C. | 01/21/2010 |
| Bone marrow cells produce a novel TSHb splice variant that is upregulated in the thyroid following systemic virus infection. | Bone marrow cells produce a novel TSHbeta splice variant that is upregulated in the thyroid following systemic virus infection.
Vincent BH, Montufar-Solis D, Teng BB, Amendt BA, Schaefer J, Klein JR., Free PMC Article | 01/21/2010 |
| findings have direct functional implications for understanding a TSH immune-endocrine circuit in the small intestine | Virus infection activates thyroid stimulating hormone synthesis in intestinal epithelial cells.
Varghese S, Montufar-Solis D, Vincent BH, Klein JR., Free PMC Article | 01/21/2010 |
| multiple domains of Pit-1 are required for full synergy with GATA-2 and sequences between the two binding sites contribute to co-occupancy with both factors on the proximal TSH beta promoter | Domains of Pit-1 required for transcriptional synergy with GATA-2 on the TSH beta gene.
Gordon DF, Woodmansee WW, Black JN, Dowding JM, Bendrick-Peart J, Wood WM, Ridgway EC. | 01/21/2010 |
| TRH is absolutely required for both TSH and TH synthesis but is not necessary for thyrotroph cell development | Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.
Nikrodhanond AA, Ortiga-Carvalho TM, Shibusawa N, Hashimoto K, Liao XH, Refetoff S, Yamada M, Mori M, Wondisford FE. | 01/21/2010 |
| N-CoR and TRbeta cooperate in the regulation of the TSHbeta gene and this ligand-dependent repression is mediated by the LXXLL motif in N-CoR | An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene.
Loinder K, Söderström M. | 01/21/2010 |
| sythesis of thyrotropin in CD45+ hematopoietic bone marrow cells and involvement in the regulation of TNF-alpha by CD11b(-) BM cells | An intrinsic thyrotropin-mediated pathway of TNF-alpha production by bone marrow cells.
Wang HC, Dragoo J, Zhou Q, Klein JR. | 01/21/2010 |
| TSH is a negative regulator of skeletal remodeling. | TSH is a negative regulator of skeletal remodeling.
Abe E, Marians RC, Yu W, Wu XB, Ando T, Li Y, Iqbal J, Eldeiry L, Rajendren G, Blair HC, Davies TF, Zaidi M. | 01/21/2010 |
| TSHbeta gene is maximally activated by a combination of TRAP220, Pit-1, GATA-2 that act via both protein-DNA and protein-protein interactions. | MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes.
Gordon DF, Tucker EA, Tundwal K, Hall H, Wood WM, Ridgway EC. | 01/21/2010 |