| Evaluation value and mechanism of ADRB2 and FCER1B gene polymorphisms in preterm infants with congenital respiratory diseases. | Evaluation value and mechanism of ADRB2 and FCER1B gene polymorphisms in preterm infants with congenital respiratory diseases.
Liu J, Zhu Q, Jiang H, Zhang L, Cao X. | 01/4/2024 |
| Identification of redundancy between human FcepsilonRIbeta and MS4A6A proteins points toward additional complex mechanisms for FcepsilonRI trafficking and signaling. | Identification of redundancy between human FcεRIβ and MS4A6A proteins points toward additional complex mechanisms for FcεRI trafficking and signaling.
Bitting K, Hedgespeth B, Ehrhardt-Humbert LC, Arthur GK, Schubert AG, Bradding P, Tilley SL, Cruse G., Free PMC Article | 05/3/2023 |
| Interaction between antibiotic use and MS4A2 gene polymorphism on childhood eczema: a prospective birth cohort study. | Interaction between antibiotic use and MS4A2 gene polymorphism on childhood eczema: a prospective birth cohort study.
Hua L, Chen Q, Liu QH, Guo YF, Cheng RH, Zhang J, Zhang JH, Wang LW, Ji RX., Free PMC Article | 08/14/2021 |
| Using immunohistochemistry, we validated that MS4A2, the beta subunit of the IgE receptor expressed on mast cells, is a favorable prognostic indicator and show that MS4A2 gene expression is an independent prognostic marker for early-stage lung cancer patient survival. | Role for High-Affinity IgE Receptor in Prognosis of Lung Adenocarcinoma Patients.
Ly D, Zhu CQ, Cabanero M, Tsao MS, Zhang L. | 05/5/2018 |
| in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels. | A Nonsynonymous FCER1B SNP is Associated with Risk of Developing Allergic Rhinitis and with IgE Levels.
Amo G, García-Menaya J, Campo P, Cordobés C, Plaza Serón MC, Ayuso P, Esguevillas G, Blanca M, Agúndez JA, García-Martín E., Free PMC Article | 01/14/2017 |
| study found a difference in the frequencies of genotypes of FcvarepsilonRIbeta subunit int 2 in allergic rhinitis patients and controls. The FcvarepsilonRIbeta subunit int 2 gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort | High-affinity IgE receptor gene polymorphism and allergic rhinitis in a Polish population.
Korzycka-Zaborowska B, Zielińska-Bliźniewska H, Miłoński J, Olszewski J. | 10/22/2016 |
| MS4A2 was differentially expressed between Fibromyalgia patients and healthy controls. | Genome-wide expression profiling in the peripheral blood of patients with fibromyalgia.
Jones KD, Gelbart T, Whisenant TC, Waalen J, Mondala TS, Iklé DN, Salomon DR, Bennett RM, Kurian SM., Free PMC Article | 07/16/2016 |
| no association between gene polymorphism and chronic spontaneous urticaria in Kashmiri population | IgE FcɛR1β polymorphism and risk of developing chronic spontaneous urticaria: A study in an ethnic Kashmiri population.
Rasool R, Shera IA, Nissar S, Yousuf Q, Shah ZA. | 02/20/2016 |
| FcepsilonRIbeta -109C/T and IFN-gamma 874T/A polymorphisms may be influencing factors for asthma in the Asian population | Association between FcεRIβ and IFN-γ Polymorphisms and Asthma in Asian Population: a Meta-Analysis.
Yao YS, Li J, Jin YL, He LP, Chang WW, Chen Y, Ding LL, Lu W, Li CP. | 10/31/2015 |
| The results explain how initial membrane interactions of clustered IgE-Fcepsilon RI complexes lead to downstream cellular responses. | Nanodomains in early and later phases of FcɛRI signalling.
Holowka D, Baird B., Free PMC Article | 10/24/2015 |
| Data indicated that the MS4A2 gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians. | Association of the MS4A2 gene promoter C-109T or the 7th exon E237G polymorphisms with asthma risk: a meta-analysis.
Yang HJ, Zheng L, Zhang XF, Yang M, Huang X. | 01/3/2015 |
| Cytoplasmic FcepsilonRIbeta, which is not co-localized with FcepsilonRIalpha, may function as a negative regulator, as it can capture important signalling molecules such as Lyn. | Highly expressed cytoplasmic FcεRIβ in human mast cells functions as a negative regulator of the FcRγ-mediated cell activation signal.
Okayama Y, Matsuda A, Kashiwakura JI, Sasaki-Sakamoto T, Nunomura S, Shimokawa T, Yamaguchi K, Takahashi S, Ra C. | 09/20/2014 |
| t-FcepsilonRIbeta mediates Ca2+ -dependent microtubule formation, which promotes degranulation and cytokine release. | A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells.
Cruse G, Beaven MA, Ashmole I, Bradding P, Gilfillan AM, Metcalfe DD., Free PMC Article | 08/3/2013 |
| The interaction between Lyn and FcepsilonRIbeta is indispensable for FcepsilonRI-mediated human mast cell activation. | The interaction between Lyn and FcεRIβ is indispensable for FcεRI-mediated human mast cell activation.
Okayama Y, Kashiwakura JI, Matsuda A, Sasaki-Sakamoto T, Nunomura S, Yokoi N, Ebihara N, Kuroda K, Ohmori K, Saito H, Ra C. | 02/2/2013 |
| Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis. | Demethylation of the FCER1G promoter leads to FcεRI overexpression on monocytes of patients with atopic dermatitis.
Liang Y, Wang P, Zhao M, Liang G, Yin H, Zhang G, Wen H, Lu Q. | 06/16/2012 |
| Polymorphisms in the Fc epsilon R1beta gene confer susceptibility to atopy in Korean children and may have a disease-modifying effect on airways in asthmatic patients. | Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma.
Kim ES, Kim SH, Kim KW, Park HS, Shin ES, Lee JE, Sohn MH, Kim KE. | 11/27/2010 |
| No associations with total and specific IgE levels as well as allergic sensitization were seen for FCER1B and FCER1G | Analysis of the high affinity IgE receptor genes reveals epistatic effects of FCER1A variants on eczema risk.
Mahachie John JM, Baurecht H, Rodríguez E, Naumann A, Wagenpfeil S, Klopp N, Mempel M, Novak N, Bieber T, Wichmann HE, Ring J, Illig T, Cattaert T, Van Steen K, Weidinger S. | 10/30/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Methylation levels at the AluSp repeat analysed in MS4A2 were inconsistent with classical imprinting mechanisms and did not associate with atopy status | Characterization of the methylation patterns of MS4A2 in atopic cases and controls.
Ferreira MA, Oates NA, van Vliet J, Zhao ZZ, Ehrich M, Martin NG, Montgomery GW, Whitelaw E, Duffy DL. | 08/23/2010 |
| Significant associations of single nucleotide polymorphisms with wheeze in the past year were detected in only four genes (IL4R, TLR4, MS4A2, TLR9). Variants in IL4R and TLR4 were also related to allergen-specific IgE, but not for MS4A2 and TLR9. | A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.
Genuneit J, Cantelmo JL, Weinmayr G, Wong GW, Cooper PJ, Riikjärv MA, Gotua M, Kabesch M, von Mutius E, Forastiere F, Crane J, Nystad W, El-Sharif N, Batlles-Garrido J, García-Marcos L, García-Hernández G, Morales-Suarez-Varela M, Nilsson L, Bråbäck L, Saraçlar Y, Weiland SK, Cookson WO, Strachan D, Moffatt MF, ISAAC Phase 2 Study Group. | 04/19/2010 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) | Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF., Free PMC Article | 04/7/2010 |
| A promoter-dependent mechanism with altered transcriptional regulation of FcepsilonRIbeta may be involved for its association with asthma. | Promoter polymorphism in the MS4A2 gene and asthma in the Indian population.
Sharma S, Ghosh B. | 01/21/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
Wang X, Cheng S, Brophy VH, Erlich HA, Mannhalter C, Berger K, Lalouschek W, Browner WS, Shi Y, Ringelstein EB, Kessler C, Luedemann J, Lindpaintner K, Liu L, Ridker PM, Zee RY, Cook NR, RMS Stroke SNP Consortium., Free PMC Article | 03/25/2009 |
| The -237T>G polymorphism may be associated with the rate of atopy, which in turn could increase the release of histamine from basophils and may lead to the development of the aspirin-intolerant chronic urticaria | Analysis of high-affinity IgE receptor (FcepsilonR1) polymorphisms in patients with aspirin-intolerant chronic urticaria.
Palikhe N, Kim SH, Yang EM, Kang YM, Ye YM, Hur GY, Park HS. | 01/21/2010 |
| The data suggested that the Gly237Gly genotype of the Fc epsilon RI beta gene conferred genetic susceptibility to allergic asthma in Chinese, which affected the total plasma IgE levels in the allergic asthma patients. | [Study on the high-affinity IgE receptor beta gene polymorphism and its association with the susceptibility to allergic asthma in Han nationality of Hubei province].
Cui TP, Wang L, Xie JG, Hu LH, Wu JM. | 01/21/2010 |