| Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1. | Roquin-2 promotes oxidative stress-induced cell death by ubiquitination-dependent degradation of TAK1.
Hirata Y, Nakata Y, Komatsu H, Kudoh Y, Takahashi M, Taguchi S, Noguchi T, Matsuzawa A. | 06/27/2024 |
| Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1. | Mycobacterium tuberculosis Rv1043c regulates the inflammatory response by inhibiting the phosphorylation of TAK1.
Li W, Yan ZF, Teng TS, Xiang XH. | 06/7/2024 |
| Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis. | Disruption of TIGAR-TAK1 alleviates immunopathology in a murine model of sepsis.
Wang D, Li Y, Yang H, Shen X, Shi X, Li C, Zhang Y, Liu X, Jiang B, Zhu X, Zhang H, Li X, Bai H, Yang Q, Gao W, Bai F, Ji Y, Chen Q, Ben J., Free PMC Article | 05/29/2024 |
| TR4 worsen urosepsis by regulating GSDMD. | TR4 worsen urosepsis by regulating GSDMD.
Wang H, Zhu S, Zhou Z, Wang Z, Zhuang W, Xue D, Lu Z, Zheng Q, Ding L, Ren L, Luo W, Wang R, Ge G, Xia L, Li G, Wu H., Free PMC Article | 03/7/2024 |
| TAK1 is an essential kinase for STING trafficking. | TAK1 is an essential kinase for STING trafficking.
Ma M, Dang Y, Chang B, Wang F, Xu J, Chen L, Su H, Li J, Ge B, Chen C, Liu H. | 11/10/2023 |
| Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death. | Small molecule activators of TAK1 promotes its activity-dependent ubiquitination and TRAIL-mediated tumor cell death.
Sun W, Wu G, Tian X, Qi C, Liu J, Tong Y, Zhang M, Gao J, Cao Z, Zhang Y, Liu Z, Tian X, Wu P, Peng C, Li J, Tan L, Shan B, Liu J, Li Y, Yuan J., Free PMC Article | 09/26/2023 |
| Transforming Growth Factor-beta-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain. | Transforming Growth Factor-β-Activated Kinase 1 (TAK1) Mediates Chronic Pain and Cytokine Production in Mouse Models of Inflammatory, Neuropathic, and Primary Pain.
Scarneo S, Zhang X, Wang Y, Camacho-Domenech J, Ricano J, Hughes P, Haystead T, Nackley AG., Free PMC Article | 09/8/2023 |
| p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression. | p-TAK1 acts as a switch between myoblast proliferation phase and differentiation phase in mdx mice via regulating HO-1 expression.
Fan S, Huang X, Tong H, Hong H, Lai Z, Hu W, Liu X, Zhang L, Jiang Z, Yu Q. | 10/15/2022 |
| Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection. | Viperin impairs the innate immune response through the IRAK1-TRAF6-TAK1 axis to promote Mtb infection.
Zhou X, Zhang Z, Xu H, Zhu B, Zhang L, Lie L, Huang Y, Du X, Liu H, Li Y, Huang Y, Hu S, Zhou C, Wen Q, Pepplenbosch MP, Ma L. | 10/8/2022 |
| Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors. | Gonadal hormone trigger the dynamic microglial alterations through Traf6/TAK1 axis that correlate with depressive behaviors.
Peng R, Dai W, Li D, Li Y. | 07/30/2022 |
| TAK1 is essential for endothelial barrier maintenance and repair after lung vascular injury. | TAK1 is essential for endothelial barrier maintenance and repair after lung vascular injury.
Wang DM, Soni D, Regmi SC, Vogel SM, Tiruppathi C., Free PMC Article | 07/30/2022 |
| Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1. | Small extracellular vesicle-mediated miR-320e transmission promotes osteogenesis in OPLL by targeting TAK1.
Xu C, Zhang Z, Liu N, Li L, Zhong H, Wang R, Shi Q, Zhang Z, Wei L, Hu B, Zhang H, Shen X, Wang Y, Liu Y, Yuan W., Free PMC Article | 05/14/2022 |
| Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy. | Supraphysiological activation of TAK1 promotes skeletal muscle growth and mitigates neurogenic atrophy.
Roy A, Kumar A., Free PMC Article | 05/14/2022 |
| TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway. | TBC1D25 Regulates Cardiac Remodeling Through TAK1 Signaling Pathway.
Guo S, Liu Y, Gao L, Xiao F, Shen J, Xing S, Yang F, Zhang W, Shi Q, Li Y, Zhao L., Free PMC Article | 10/2/2021 |
| Deficiency of Lipin2 Results in Enhanced NF-kappaB Signaling and Osteoclast Formation in RAW-D Murine Macrophages. | Deficiency of Lipin2 Results in Enhanced NF-κB Signaling and Osteoclast Formation in RAW-D Murine Macrophages.
Watahiki A, Hoshikawa S, Chiba M, Egusa H, Fukumoto S, Inuzuka H., Free PMC Article | 04/24/2021 |
| Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma. | Hepatocyte-specific TAK1 deficiency drives RIPK1 kinase-dependent inflammation to promote liver fibrosis and hepatocellular carcinoma.
Tan S, Zhao J, Sun Z, Cao S, Niu K, Zhong Y, Wang H, Shi L, Pan H, Hu J, Qian L, Liu N, Yuan J., Free PMC Article | 08/29/2020 |
| TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine-induced chemokine production and neutrophil migration. | TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine-induced chemokine production and neutrophil migration.
Soto-Díaz K, Juda MB, Blackmore S, Walsh C, Steelman AJ. | 08/29/2020 |
| IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion. | IRF6 and TAK1 coordinately promote the activation of HIPK2 to stimulate apoptosis during palate fusion.
Ke CY, Mei HH, Wong FH, Lo LJ. | 08/15/2020 |
| The loss of TAK1 signaling reduces inappropriate tissue formation (heterotopic ossi fi cation) through reduced cellular differentiation. | Coordinating Tissue Regeneration Through Transforming Growth Factor-β Activated Kinase 1 Inactivation and Reactivation.
Hsieh HHS, Agarwal S, Cholok DJ, Loder SJ, Kaneko K, Huber A, Chung MT, Ranganathan K, Habbouche J, Li J, Butts J, Reimer J, Kaura A, Drake J, Breuler C, Priest CR, Nguyen J, Brownley C, Peterson J, Ozgurel SU, Niknafs YS, Li S, Inagaki M, Scott G, Krebsbach PH, Longaker MT, Westover K, Gray N, Ninomiya-Tsuji J, Mishina Y, Levi B., Free PMC Article | 05/2/2020 |
| Notch4 inhibited Mycobacterium tuberculosis-induced production of proinflammatory cytokines by interaction with TAK1 and inhibition of its activation. | Notch4 Negatively Regulates the Inflammatory Response to Mycobacterium tuberculosis Infection by Inhibiting TAK1 Activation.
Zheng R, Liu H, Zhou Y, Yan D, Chen J, Ma D, Feng Y, Qin L, Liu F, Huang X, Wang J, Ge B. | 09/14/2019 |
| our data suggest that NUMBL and TAK1 are reciprocally regulated and that NUMBL acts as an endogenous regulator of NF-kappaB signaling and osteoclastogenesis by targeting the TAK1-TRAF6-NEMO axis. | NUMBL Interacts with TAK1, TRAF6 and NEMO to Negatively Regulate NF-κB Signaling During Osteoclastogenesis.
Swarnkar G, Chen TH, Arra M, Nasir AM, Mbalaviele G, Abu-Amer Y., Free PMC Article | 06/29/2019 |
| our findings demonstrate that CYLD mitigates Nonalcoholic steatohepatitis severity and identify the CYLD-TAK1 axis as a promising therapeutic target for management of the disease. | The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H. | 05/11/2019 |
| This study demonstrated that Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke. | Myeloid-specific TAK1 deletion results in reduced brain monocyte infiltration and improved outcomes after stroke.
Chauhan A, Hudobenko J, Al Mamun A, Koellhoffer EC, Patrizz A, Ritzel RM, Ganesh BP, McCullough LD., Free PMC Article | 04/13/2019 |
| TNFalpha-induced phosphorylation of RIPK1 in the intermediate domain by TAK1 plays a key role in regulating the decision between three distinct mechanisms of cell death: necroptosis, RIPK1-independent and dependent apoptosis. | Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis.
Geng J, Ito Y, Shi L, Amin P, Chu J, Ouchida AT, Mookhtiar AK, Zhao H, Xu D, Shan B, Najafov A, Gao G, Akira S, Yuan J., Free PMC Article | 12/23/2017 |
| The results suggest that an intron-free Renilla luciferase reporter may provide a satisfactory internal control for TR4 at certain dose range. Findings advocate caution on the use of Renilla luciferase as an internal control in TR4-directed studies to avoid misleading data interpretation. | False responses of Renilla luciferase reporter control to nuclear receptor TR4.
Zhang D, Atlasi SS, Patel KK, Zhuang Z, Heaney AP. | 12/23/2017 |