| TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation. | TOP2A modulates signaling via the AKT/mTOR pathway to promote ovarian cancer cell proliferation.
Zhang K, Zheng X, Sun Y, Feng X, Wu X, Liu W, Gao C, Yan Y, Tian W, Wang Y., Free PMC Article | 03/7/2024 |
| Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components. | Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components.
Muciño-Hernández G, Acevo-Rodríguez PS, Cabrera-Benitez S, Guerrero AO, Merchant-Larios H, Castro-Obregón S., Free PMC Article | 02/10/2023 |
| Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37. | Topoisomerase IIA in adult NSCs regulates SVZ neurogenesis by transcriptional activation of Usp37.
Qin S, Yuan Y, Huang X, Tan Z, Hu X, Liu H, Pu Y, Ding YQ, Su Z, He C., Free PMC Article | 01/28/2023 |
| TOP2-mediated double-strand breaks is a major driving force of thymic malignancies linked to ATM deficiency. | Endogenous topoisomerase II-mediated DNA breaks drive thymic cancer predisposition linked to ATM deficiency.
Álvarez-Quilón A, Terrón-Bautista J, Delgado-Sainz I, Serrano-Benítez A, Romero-Granados R, Martínez-García PM, Jimeno-González S, Bernal-Lozano C, Quintero C, García-Quintanilla L, Cortés-Ledesma F., Free PMC Article | 06/6/2020 |
| RNF168 interacts with TOP2alpha to mediate its polyubiquitylation and RNF168 deficiency confers resistance to ICRF-193, a TOP2 catalytic inhibitor, and cytotoxic anti-cancer drug etoposide in cultured mouse cells. | RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.
Guturi KKN, Bohgaki M, Bohgaki T, Srikumar T, Ng D, Kumareswaran R, El Ghamrasni S, Jeon J, Patel P, Eldin MS, Bristow R, Cheung P, Stewart GS, Raught B, Hakem A, Hakem R., Free PMC Article | 09/15/2018 |
| Topo IIalpha plays an important role in adipogenesis. | DNA Topoisomerase IIα contributes to the early steps of adipogenesis in 3T3-L1 cells.
Jacobsen RG, Mazloumi Gavgani F, Mellgren G, Lewis AE. | 12/2/2017 |
| Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II-targeting agents. | Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.
Pett L, Kiakos K, Satam V, Patil P, Laughlin-Toth S, Gregory M, Bowerman M, Olson K, Savagian M, Lee M, Lee M, Wilson WD, Hochhauser D, Hartley JA., Free PMC Article | 08/19/2017 |
| TOP2 and BAF cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF complexes. | TOP2 synergizes with BAF chromatin remodeling for both resolution and formation of facultative heterochromatin.
Miller EL, Hargreaves DC, Kadoch C, Chang CY, Calarco JP, Hodges C, Buenrostro JD, Cui K, Greenleaf WJ, Zhao K, Crabtree GR., Free PMC Article | 06/24/2017 |
| Deletion or deficiency of PTEN leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases. | PTEN stabilizes TOP2A and regulates the DNA decatenation.
Kang X, Song C, Du X, Zhang C, Liu Y, Liang L, He J, Lamb K, Shen WH, Yin Y., Free PMC Article | 10/22/2016 |
| Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity | Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy.
Wyles SP, Yamada S, Oommen S, Maleszewski JJ, Beraldi R, Martinez-Fernandez A, Terzic A, Nelson TJ., Free PMC Article | 11/21/2015 |
| Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II. | Cohesin removal precedes topoisomerase IIα-dependent decatenation at centromeres in male mammalian meiosis II.
Gómez R, Viera A, Berenguer I, Llano E, Pendás AM, Barbero JL, Kikuchi A, Suja JA. | 11/22/2014 |
| Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug. | UPR-induced resistance to etoposide is downstream of PERK and independent of changes in topoisomerase IIα levels.
Mann MJ, Pereira ER, Liao N, Hendershot LM., Free PMC Article | 08/30/2014 |
| Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation. | Gene regulation and priming by topoisomerase IIα in embryonic stem cells.
Thakurela S, Garding A, Jung J, Schübeler D, Burger L, Tiwari VK. | 04/26/2014 |
| studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF complexes and suggest that this activity contributes to the role of BAF subunits as tumour suppressors | BAF complexes facilitate decatenation of DNA by topoisomerase IIα.
Dykhuizen EC, Hargreaves DC, Miller EL, Cui K, Korshunov A, Kool M, Pfister S, Cho YJ, Zhao K, Crabtree GR., Free PMC Article | 06/22/2013 |
| our data reveal TDP2-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2-induced DSBs | TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
Gómez-Herreros F, Romero-Granados R, Zeng Z, Alvarez-Quilón A, Quintero C, Ju L, Umans L, Vermeire L, Huylebroeck D, Caldecott KW, Cortés-Ledesma F., Free PMC Article | 06/15/2013 |
| Top2alpha is suggested to be a universal target for cancer immunotherapy. | Topoisomerase II alpha as a universal tumor antigen: antitumor immunity in murine tumor models and H-2K(b)-restricted T cell epitope.
Park JS, Kim HS, Park MY, Kim CH, Chung YJ, Hong YK, Kim TG., Free PMC Article | 04/12/2010 |
| Top2A expression is also down-regulated in secondary drug-resistant tumor populations and, in one case, was accompanied by genomic deletion of Top2A. | Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
Shafee N, Smith CR, Wei S, Kim Y, Mills GB, Hortobagyi GN, Stanbridge EJ, Lee EY., Free PMC Article | 01/21/2010 |
| these data identify RanBP2 as a chromosomal instability gene that regulates Topo IIalpha by sumoylation and suppresses tumorigenesis. | Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.
Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM., Free PMC Article | 01/21/2010 |
| NK314 inhibited topoisomerase II activity and stabilized topoisomerase II-DNA cleavable complexes. | NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors.
Onda T, Toyoda E, Miyazaki O, Seno C, Kagaya S, Okamoto K, Nishikawa K. | 01/21/2010 |
| VP-16-induced carcinogenesis involves mainly the beta rather than the alpha isozyme of Top2 | Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies.
Azarova AM, Lyu YL, Lin CP, Tsai YC, Lau JY, Wang JC, Liu LF., Free PMC Article | 01/21/2010 |
| DNA topoisomerase II is essential for preimplantation mouse development | DNA topoisomerase II is essential for preimplantation mouse development.
St Pierre J, Wright DJ, Rowe TC, Wright SJ. | 01/21/2010 |
| DNA topoisomerase II distribution in mouse preimplantation embryos | DNA topoisomerase II distribution in mouse preimplantation embryos.
St Pierre J, Wright DJ, Rowe TC, Wright SJ. | 01/21/2010 |
| Results suggest that topo IIalpha-depleted cells with the droplet-like nuclear structure induce apoptosis, which is dependent on caspase and p53 activity during the G1 phase in mammalian cells. | Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells.
Akimitsu N, Kamura K, Toné S, Sakaguchi A, Kikuchi A, Hamamoto H, Sekimizu K. | 01/21/2010 |
| The role of topoisomerase II in the excision of DNA loop domains during apoptosis. | The role of topoisomerase II in the excision of DNA loop domains during apoptosis.
Solovyan VT, Bezvenyuk ZA, Salminen A, Austin CA, Courtney MJ. | 01/21/2010 |
| The functional status of pRb protein may influence sensitivity to etoposide by facilitating the repair of trapped TOP2-DNA complexes. | The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes.
Xiao H, Goodrich DW., Free PMC Article | 01/21/2010 |