| Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells. | Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells.
Grenell A, Singh C, Raju M, Wolk A, Dalvi S, Jang GF, Crabb JS, Hershberger CE, Manian KV, Hernandez K, Crabb JW, Singh R, Du J, Anand-Apte B., Free PMC Article | 09/24/2024 |
| TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation. | TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation.
Guo P, Ru X, Zhou J, Chen M, Li Y, Duan M, Li Y, Li W, Chen Y, Zuo S, Feng H., Free PMC Article | 04/22/2024 |
| TIMP3/Wnt axis regulates gliosis of Muller glia. | TIMP3/Wnt axis regulates gliosis of Müller glia.
Hung JH, Tsai PH, Aala WJF, Chen CC, Chiou SH, Wong TW, Tsai KJ, Hsu SM, Wu LW. | 04/16/2024 |
| TIMP3 overexpression in myeloid lineage alleviates pancreatic damage and confers resistance to the development of type 1 diabetes in the MLDS -induced model. | TIMP3 overexpression in myeloid lineage alleviates pancreatic damage and confers resistance to the development of type 1 diabetes in the MLDS -induced model.
Casagrande V, Menini S, Internò C, Pugliese G, Federici M, Menghini R., Free PMC Article | 02/6/2024 |
| Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm. | Loss of TIMP3, but not TIMP4, exacerbates thoracic and abdominal aortic aneurysm.
Hu M, Meganathan I, Zhu J, MacArthur R, Kassiri Z. | 12/15/2023 |
| The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development. | The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
Davis FM, Melvin WJ, Mangum K, Tsoi LC, Joshi AD, Cai Q, Henke PK, Gudjonsson JE, Gallagher KA., Free PMC Article | 08/11/2023 |
| Pioglitazone Attenuates Lupus Nephritis Symptoms in Mice by Modulating miR-21-5p/TIMP3 Axis: the Key Role of the Activation of Peroxisome Proliferator-Activated Receptor-gamma. | Pioglitazone Attenuates Lupus Nephritis Symptoms in Mice by Modulating miR-21-5p/TIMP3 Axis: the Key Role of the Activation of Peroxisome Proliferator-Activated Receptor-γ.
Liu D, Zhang W. | 12/25/2021 |
| The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration. | The retinal pigment epithelium in Sorsby Fundus Dystrophy shows increased sensitivity to oxidative stress-induced degeneration.
Wolk A, Upadhyay M, Ali M, Suh J, Stoehr H, Bonilha VL, Anand-Apte B., Free PMC Article | 05/29/2021 |
| Overexpression of Linc 4930556M19Rik Suppresses High Glucose-Triggered Podocyte Apoptosis, Fibrosis and Inflammation via the miR-27a-3p/Metalloproteinase 3 (TIMP3) Axis in Diabetic Nephropathy. | Overexpression of Linc 4930556M19Rik Suppresses High Glucose-Triggered Podocyte Apoptosis, Fibrosis and Inflammation via the miR-27a-3p/Metalloproteinase 3 (TIMP3) Axis in Diabetic Nephropathy.
Fan H, Zhang W., Free PMC Article | 05/22/2021 |
| MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3. | MiR-770-5p facilitates podocyte apoptosis and inflammation in diabetic nephropathy by targeting TIMP3.
Wang L, Li H., Free PMC Article | 04/3/2021 |
| Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis. | Aggrecanase-selective tissue inhibitor of metalloproteinase-3 (TIMP3) protects articular cartilage in a surgical mouse model of osteoarthritis.
Nakamura H, Vo P, Kanakis I, Liu K, Bou-Gharios G., Free PMC Article | 12/12/2020 |
| Timp3 ablation leads to cell cycle perturbation, at least in part by repressing FoxM1 transcriptional activity through H19/miR-675/p53 pathway. | Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice.
Casagrande V, Mauriello A, Anemona L, Mavilio M, Iuliani G, De Angelis L, D'Onofrio M, Arisi I, Federici M, Menghini R. | 01/18/2020 |
| the absence of TIMP-3 leads to a more pro-angiogenic microenvironment, playing a key role in choroidal neovascularization formation by positively modulating M2 polarization. | TIMP-3 suppression induces choroidal neovascularization by moderating the polarization of macrophages in age-related macular degeneration.
Cheng Y, Cheng T, Qu Y. | 05/4/2019 |
| the aim of this study was to determine whether Acanthamoeba spp. may affect the levels of matrix metalloproteinases (MMP-2,-9), their tissue inhibitors (TIMP-1,-3) and MMP-9/TIMP-1, MMP-2/TIMP-3 ratios in the cerebral cortex and hippocampus, in relation to the host's immunological status. | The Activity of Matrix Metalloproteinases (MMP-2, MMP-9) and Their Tissue Inhibitors (TIMP-1, TIMP-3) in the Cerebral Cortex and Hippocampus in Experimental Acanthamoebiasis.
Łanocha-Arendarczyk N, Baranowska-Bosiacka I, Gutowska I, Kolasa-Wołosiuk A, Kot K, Łanocha A, Metryka E, Wiszniewska B, Chlubek D, Kosik-Bogacka D., Free PMC Article | 04/6/2019 |
| The data indicate that hepatic TIMP3 expression can slow the progression of nonalcoholic fatty liver disease and tumorigenesis, at least in part, through the regulation of ADAM17 activity. | Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma.
Casagrande V, Mauriello A, Bischetti S, Mavilio M, Federici M, Menghini R., Free PMC Article | 02/16/2019 |
| Loss of Timp3 enhanced the susceptibility to iron overload-mediated heart and liver injury, suggesting that Timp3 is a key protective molecule against iron-mediated pathology. | TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.
Zhabyeyev P, Das SK, Basu R, Shen M, Patel VB, Kassiri Z, Oudit GY., Free PMC Article | 01/12/2019 |
| Loss of TIMP3 is associated with germinal matrix hemorrhage-intraventricular hemorrhage. | Pericyte ALK5/TIMP3 Axis Contributes to Endothelial Morphogenesis in the Developing Brain.
Dave JM, Mirabella T, Weatherbee SD, Greif DM., Free PMC Article | 06/2/2018 |
| altered cortical and trabecular bone mineralization and increased compositional heterogeneity were found in Timp-3 (-/-) bone, all being indicative of high bone remodeling | Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice.
Miller B, Spevak L, Lukashova L, Javaheri B, Pitsillides AA, Boskey A, Bou-Gharios G, Carriero A. | 03/3/2018 |
| In a clinically relevant CADASIL mouse model, we show that exogenous ADAM17 or HB-EGF restores cerebral arterial tone and blood flow responses, and identify upregulated voltage-dependent potassium channel (KV) number in cerebral arterial myocytes as a heretofore-unrecognized downstream effector of TIMP3-induced deficits. | Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics.
Capone C, Dabertrand F, Baron-Menguy C, Chalaris A, Ghezali L, Domenga-Denier V, Schmidt S, Huneau C, Rose-John S, Nelson MT, Joutel A., Free PMC Article | 10/28/2017 |
| TIMP3 promotes normal microvascular endothelial cell barrier function, at least partially, through inhibition of metalloproteinase-dependent disruption of adherens junctions, and septic downregulation of TIMP3 may contribute to septic MVEC barrier dysfunction. | Tissue inhibitor of metalloproteinases 3-dependent microvascular endothelial cell barrier function is disrupted under septic conditions.
Arpino V, Mehta S, Wang L, Bird R, Rohan M, Pape C, Gill SE. | 07/1/2017 |
| data strongly suggest that TIMP3 has direct neuroprotective effects that can mitigate the deleterious effects associated with TBI, an area with few if any therapeutic options. | TIMP3 Attenuates the Loss of Neural Stem Cells, Mature Neurons and Neurocognitive Dysfunction in Traumatic Brain Injury.
Gibb SL, Zhao Y, Potter D, Hylin MJ, Bruhn R, Baimukanova G, Zhao J, Xue H, Abdel-Mohsen M, Pillai SK, Moore AN, Johnson EM, Cox CS Jr, Dash PK, Pati S. | 10/29/2016 |
| Elevated levels of TIMP3 and vitronectin, acting downstream of Notch3(ECD) deposition, play a role in CADASIL, producing divergent influences on early CBF deficits and later white matter lesions. | Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice.
Capone C, Cognat E, Ghezali L, Baron-Menguy C, Aubin D, Mesnard L, Stöhr H, Domenga-Denier V, Nelson MT, Joutel A., Free PMC Article | 07/30/2016 |
| 4-Hydroxyisoleucine improved insulin resistant-like state in 3T3-L1 adipocytes by targeting TACE/TIMP3 and the insulin signaling pathway. | 4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression.
Gao F, Du W, Zafar MI, Shafqat RA, Jian L, Cai Q, Lu F., Free PMC Article | 07/16/2016 |
| In a mouse model of prostate cancer, increased tumor growth, proliferation index, increased microvascular density, and invasion was observed in Pten(-/-), Timp3(-/-) prostate tumors compared to Pten(-/-), Timp3(+/+) tumors. | Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer.
Adissu HA, McKerlie C, Di Grappa M, Waterhouse P, Xu Q, Fang H, Khokha R, Wood GA. | 02/6/2016 |
| Timp3 status determines p53, p38 and Notch coactivation to instruct hepatic cell fate and transformation. | TIMP3 controls cell fate to confer hepatocellular carcinoma resistance.
Defamie V, Sanchez O, Murthy A, Khokha R. | 10/24/2015 |