| Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRalpha and TRbeta. | Comparative Phenotyping of Mice Reveals Canonical and Noncanonical Physiological Functions of TRα and TRβ.
Hönes GS, Geist D, Wenzek C, Pfluger PT, Müller TD, Aguilar-Pimentel JA, Amarie OV, Becker L, Dragano N, Garrett L, Hölter SM, Rathkolb B, Rozman J, Spielmann N, Treise I, Wolf E, Wurst W, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Führer D, Moeller LC. | 07/11/2024 |
| Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice. | Canonical and Noncanonical Contribution of Thyroid Hormone Receptor Isoforms Alpha and Beta to Cardiac Hypertrophy and Heart Rate in Male Mice.
Geist D, Hönes GS, Grund SC, Pape J, Siemes D, Spangenberg P, Tolstik E, Dörr S, Spielmann N, Fuchs H, Gailus-Durner V, Hrabe de Angelis M, Mittag J, Engel DR, Führer D, Lorenz K, Moeller LC. | 06/28/2024 |
| Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson's. | Nr1h4 and Thrb ameliorate ER stress and provide protection in the MPTP mouse model of Parkinson's.
Ahuja N, Gupta S, Arora R, Bhagyaraj E, Tiwari D, Kumar S, Gupta P., Free PMC Article | 04/17/2024 |
| Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro. | Thyroid hormone receptor Thra and Thrb knockout differentially affects osteoblast biology and thyroid hormone responsiveness in vitro.
Lademann F, Tsourdi E, Hofbauer LC, Rauner M. | 12/21/2023 |
| Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function. | Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.
Liu H, Lu A, Kelley KA, Forrest D., Free PMC Article | 02/4/2023 |
| Thyroid hormone receptor beta sumoylation is required for thyrotropin regulation and thyroid hormone production. | Thyroid hormone receptor β sumoylation is required for thyrotropin regulation and thyroid hormone production.
Ke S, Liu YY, Karthikraj R, Kannan K, Jiang J, Abe K, Milanesi A, Brent GA., Free PMC Article | 02/26/2022 |
| Transcriptome and ChIP-seq analyses and found that many genes that were co-regulated by both THRB1 and ESRRA were involved in mitochondrial metabolic pathways. | Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function.
Singh BK, Sinha RA, Tripathi M, Mendoza A, Ohba K, Sy JAC, Xie SY, Zhou J, Ho JP, Chang CY, Wu Y, Giguère V, Bay BH, Vanacker JM, Ghosh S, Gauthier K, Hollenberg AN, McDonnell DP, Yen PM. | 10/26/2019 |
| Thyroid hormone receptor beta1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion | Thyroid hormone receptor β1 stimulates ABCB4 to increase biliary phosphatidylcholine excretion in mice.
Gautherot J, Claudel T, Cuperus F, Fuchs CD, Falguières T, Trauner M., Free PMC Article | 09/14/2019 |
| Data suggest that gestational/maternal endocrine disruptor DEHP [di-(2-ethylhexyl) phthalate] exposure dose-dependently causes fetal IUGR (intrauterine growth restriction); mRNA levels of placental Thra1 and Thrb1 are reduced and nuclear translocation of placental Thra1 and Thrb1 is suppressed in DEHP-exposed mice. | Gestational di-(2-ethylhexyl) phthalate exposure causes fetal intrauterine growth restriction through disturbing placental thyroid hormone receptor signaling.
Yu Z, Han Y, Shen R, Huang K, Xu YY, Wang QN, Zhou SS, Xu DX, Tao FB. | 07/21/2018 |
| Genetic Repression in Hypothyroidism Is Mediated by Thrb1. | NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor.
Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN., Free PMC Article | 06/30/2018 |
| Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation. | Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation.
Gao X, Lee HY, Li W, Platt RJ, Barrasa MI, Ma Q, Elmes RR, Rosenfeld MG, Lodish HF., Free PMC Article | 06/9/2018 |
| TRbeta protein, target gene expression, and metabolic adaptive changes can occur in individual tissues without necessarily being reflected by circulating TH and TSH concentrations | Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model.
Ohba K, Sinha RA, Singh BK, Iannucci LF, Zhou J, Kovalik JP, Liao XH, Refetoff S, Sng JCG, Leow MK, Yen PM., Free PMC Article | 05/12/2018 |
| Using domain exchanges and individual amino acid switches between THRA1 and THRB2, three amino acids were identified in helix 10 of the THRB2 ligand-binding domain that are required for negative regulation and are absent in THRA1. | Naturally Occurring Amino Acids in Helix 10 of the Thyroid Hormone Receptor Mediate Isoform-Specific TH Gene Regulation.
Pinto VMS, Minakhina S, Qiu S, Sidhaye A, Brotherton MP, Suhotliv A, Wondisford FE., Free PMC Article | 10/7/2017 |
| Data suggest a novel role for THRbeta1 in secondary ossification at the epiphysis that involves transcriptional upregulation of Ihh gene. | Thyroid hormone receptor-β1 signaling is critically involved in regulating secondary ossification via promoting transcription of the Ihh gene in the epiphysis.
Xing W, Aghajanian P, Goodluck H, Kesavan C, Cheng S, Pourteymoor S, Watt H, Alarcon C, Mohan S., Free PMC Article | 06/10/2017 |
| In thyroid receptor-deficient mice, hair follicle stem cells present a clear defect in their mobilization (exit of their quiescent state and migration out of the niche), associated with increased activation of Smad signaling. | Thyroid hormone signaling controls hair follicle stem cell function.
Contreras-Jurado C, Lorz C, García-Serrano L, Paramio JM, Aranda A., Free PMC Article | 04/23/2016 |
| Data show that TRbeta deficiency causes dysfunction of the monoaminergic system, accompanied by epigenetic disruption during the brain maturation process. | Aberrant Monoaminergic System in Thyroid Hormone Receptor-β Deficient Mice as a Model of Attention-Deficit/Hyperactivity Disorder.
Ookubo M, Sadamatsu M, Yoshimura A, Suzuki S, Kato N, Kojima H, Yamada N, Kanai H., Free PMC Article | 02/6/2016 |
| Results suggest mutually shared roles for thyroid hormone receptor beta isoforms TRbeta1 and TRbeta2 in cochlear development. | Age-Related Hearing Loss and Degeneration of Cochlear Hair Cells in Mice Lacking Thyroid Hormone Receptor β1.
Ng L, Cordas E, Wu X, Vella KR, Hollenberg AN, Forrest D., Free PMC Article | 01/16/2016 |
| Our findings indicated that synergistic signaling of KRAS(G12D) and TRbetaPV led to increased MYC expression. | Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.
Zhu X, Zhao L, Park JW, Willingham MC, Cheng SY., Free PMC Article | 06/20/2015 |
| T3 induces FGF21 in cultured hepatocytes and this effect involves direct actions of TRbeta1, which binds a TRE within intron 2 of FGF21. But T3 induced most gene expression in liver independently of FGF21. | Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver.
Zhang A, Sieglaff DH, York JP, Suh JH, Ayers SD, Winnier GE, Kharitonenkov A, Pin C, Zhang P, Webb P, Xia X. | 04/25/2015 |
| TRbeta acts as a cytoplasmic, phosphotyrosine-dependent scaffold for the p85 regulatory subunit of PI3K and the Src kinase Lyn in the absence of thyroid hormone. | A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo.
Martin NP, Marron Fernandez de Velasco E, Mizuno F, Scappini EL, Gloss B, Erxleben C, Williams JG, Stapleton HM, Gentile S, Armstrong DL., Free PMC Article | 11/8/2014 |
| TRbeta-related deafness originates outside of hair cells and that TRalpha and TRbeta play opposing, non-redundant roles in hair cells. | Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells.
Dettling J, Franz C, Zimmermann U, Lee SC, Bress A, Brandt N, Feil R, Pfister M, Engel J, Flamant F, Rüttiger L, Knipper M. | 08/30/2014 |
| Luciferase expression driven by the midwavelength sensitive opsin intron 3-4 region was only slightly increased by THRB2, and rather enhanced by COUP-TFII. | Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.
Iwagawa T, Tanaka Y, Iida A, Itoh T, Watanabe S., Free PMC Article | 06/28/2014 |
| these data indicate that interactions between NCoR1 and TR control a specific pathway involved in regulation of cholesterol metabolism and clearance. | Hepatic nuclear corepressor 1 regulates cholesterol absorption through a TRβ1-governed pathway.
Astapova I, Ramadoss P, Costa-e-Sousa RH, Ye F, Holtz KA, Li Y, Niepel MW, Cohen DE, Hollenberg AN., Free PMC Article | 06/21/2014 |
| Taken together, the results of this study provide new insights into the mechanisms of transcriptional regulation by TRbeta1 in vivo. | Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver.
Ramadoss P, Abraham BJ, Tsai L, Zhou Y, Costa-e-Sousa RH, Ye F, Bilban M, Zhao K, Hollenberg AN., Free PMC Article | 03/22/2014 |
| Recruitment of the NRF1 and THRB to the promoters of genes. | The thyroid hormone receptor β induces DNA damage and premature senescence.
Zambrano A, García-Carpizo V, Gallardo ME, Villamuera R, Gómez-Ferrería MA, Pascual A, Buisine N, Sachs LM, Garesse R, Aranda A., Free PMC Article | 03/22/2014 |