| Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood. | Maintaining the thyroid gland in mutant thyroglobulin-induced hypothyroidism requires thyroid cell proliferation that must continue in adulthood.
Zhang X, Malik B, Young C, Zhang H, Larkin D, Liao XH, Refetoff S, Liu M, Arvan P., Free PMC Article | 07/30/2022 |
| Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin. | Thyrocyte cell survival and adaptation to chronic endoplasmic reticulum stress due to misfolded thyroglobulin.
Morishita Y, Kabil O, Young KZ, Kellogg AP, Chang A, Arvan P., Free PMC Article | 12/26/2020 |
| antepenultimate residue of TG as a major T3-forming site, but also demonstrate that the side chain of this residue intimately interacts with the same residue in the apposed monomer of the TG dimer. | Relationship between the dimerization of thyroglobulin and its ability to form triiodothyronine.
Citterio CE, Morishita Y, Dakka N, Veluswamy B, Arvan P., Free PMC Article | 04/13/2019 |
| Findings suggest that coumestrol treatment may have some beneficial actions against thyroid-specific thyroglobulin (Tg) autoantibody production in the development of autoimmune thyroiditis through suppression of Th1 response. | Coumestrol inhibits autoantibody production through modulating Th1 response in experimental autoimmune thyroiditis.
Jin X, Wang S, Zhao X, Jin Q, Fan C, Li J, Shan Z, Teng W., Free PMC Article | 02/3/2018 |
| these data identify for the first time a Tg T cell epitope as a spontaneous target in ISAT. | The thyroxine-containing thyroglobulin peptide (aa 2549-2560) is a target epitope in iodide-accelerated spontaneous autoimmune thyroiditis.
Kolypetri P, Carayanniotis K, Rahman S, Georghiou PE, Magafa V, Cordopatis P, Carayanniotis G. | 08/23/2014 |
| Final acquisition of secretory competence includes conformational maturation in the interval between linker and hinge segments of region I of thyroglobulin. | Maturation of thyroglobulin protein region I.
Lee J, Di Jeso B, Arvan P., Free PMC Article | 11/26/2011 |
| The results showed that thyroglobulin message or protein is not expressed in placenta, decidua, or ovary in any stages of pregnancy. | Evaluation of thyroglobulin expression in murine reproductive organs during pregnancy.
Moravej A, Jeddi-Tehrani M, Salek-Moghaddam AR, Dokouhaki P, Ghods R, Rabbani H, Kazemi-Sefat GE, Shahbazi M, Zarnani AH. | 10/23/2010 |
| Findings demonstrate a novel aspect of murine and human thyroid autoimmunity, namely breaking B cell self-tolerance occurs first for Tg and subsequently for TPO. | Antibodies to thyroid peroxidase arise spontaneously with age in NOD.H-2h4 mice and appear after thyroglobulin antibodies.
Chen CR, Hamidi S, Braley-Mullen H, Nagayama Y, Bresee C, Aliesky HA, Rapoport B, McLachlan SM., Free PMC Article | 10/23/2010 |
| These results indicate that Runx2 deficiency in mice causes decreased Tg expression and a novel type of hypothyroidism. | Runx2 deficiency in mice causes decreased thyroglobulin expression and hypothyroidism.
Endo T, Kobayashi T., Free PMC Article | 09/6/2010 |
| Development of iodine-accelerated autoimmune thyroiditis in NOD.H2h4 mice is not associated with enhanced iodine organification or differential B- or T-cell responses to iodinated determinants in Tg. | Iodine content of thyroglobulin in Nod.H2h4 mice developing iodine-accelerated autoimmune thyroiditis.
Kolypetri P, Noel NA, Carayanniotis KA, Carayanniotis G. | 08/30/2010 |
| specific properties of distinct Tg ChEL mutants may result in distinct patterns of Tg monomer folding | Cis and trans actions of the cholinesterase-like domain within the thyroglobulin dimer.
Wang X, Lee J, Di Jeso B, Treglia AS, Comoletti D, Dubi N, Taylor P, Arvan P., Free PMC Article | 06/28/2010 |
| Together these results suggest that a unique low molecular weight variant of Tg is expressed in the kidney, where it could serve both physiological and pathological roles, including that of an autoantigen. | Expression of a thyroglobulin (Tg) variant in mouse kidney glomerulus.
Wu H, Suzuki S, Sellitti DF, Doi SQ, Tanigawa K, Aizawa S, Akama T, Kawashima A, Mishima M, Ishii N, Yoshida A, Hisatome I, Koles NL, Katoh R, Suzuki K. | 01/21/2010 |
| Data indicate that the R19K mutation induces local misfolding in the amino-terminal domain of Tg that has global effects on Tg transport and thyroid hormonogenesis. | Defective protein folding and intracellular retention of thyroglobulin-R19K mutant as a cause of human congenital goiter.
Kim PS, Lee J, Jongsamak P, Menon S, Li B, Hossain SA, Bae JH, Panijpan B, Arvan P., Free PMC Article | 01/21/2010 |
| Tg could initiate glomerular injury by reproducing the actions of TGF-beta1 in the mesangial cell. | TGF-beta-like transcriptional effects of thyroglobulin (Tg) in mouse mesangial cells.
Sellitti DF, Puggina E, Lagranha C, Doi S, Pithon-Curi T, Kohn LD, Suzuki K. | 01/21/2010 |
| Five novel autoimmune thyroiditis-causing T cell epitopes of thyroglobulin (Tgn) have been delineated and mapped with an algorithm that predicts Tgn immunopathogenic peptides containing I-A(k)-binding motifs. | Delineation of five thyroglobulin T cell epitopes with pathogenic potential in experimental autoimmune thyroiditis.
Verginis P, Stanford MM, Carayanniotis G. | 01/21/2010 |
| iodotyrosyl formation in normal thyroglobulin confers pathogenic potential to certain peptides that may otherwise remain innocuous and undetectable by conventional mapping methods | Iodination of tyrosyls in thyroglobulin generates neoantigenic determinants that cause thyroiditis.
Li HS, Carayanniotis G. | 01/21/2010 |