| Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE. | Transforming growth factor receptor III (Betaglycan) regulates the generation of pathogenic Th17 cells in EAE.
Duesman SJ, Ortega-Francisco S, Olguin-Alor R, Acevedo-Dominguez NA, Sestero CM, Chellappan R, De Sarno P, Yusuf N, Salgado-Lopez A, Segundo-Liberato M, de Oca-Lagunas SM, Raman C, Soldevila G., Free PMC Article | 03/3/2023 |
| Ablation of TGFBR3 (betaglycan) in oocytes does not affect fertility in female mice. | Ablation of TGFBR3 (betaglycan) in oocytes does not affect fertility in female mice.
Li Y, Lin YF, Zhou X, Clarke HJ, Bernard DJ. | 01/22/2022 |
| A novel mechanism that let-7a regulate angiogenesis through post-transcriptional regulation of TGFBR3. | MicroRNA let-7a regulates angiogenesis by targeting TGFBR3 mRNA.
Wang S, Zhou H, Wu D, Ni H, Chen Z, Chen C, Xiang Y, Dai K, Chen X, Li X., Free PMC Article | 04/18/2020 |
| Both TGF-beta1 and TGF-beta3 induced endocytosis of amelogenin | Potential function of TGF-β isoforms in maturation-stage ameloblasts.
Okubo M, Chiba R, Karakida T, Yamazaki H, Yamamoto R, Kobayashi S, Niwa T, Margolis HC, Nagano T, Yamakoshi Y, Gomi K. | 04/4/2020 |
| Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation. | Plau and Tgfbr3 are YAP-regulated genes that promote keratinocyte proliferation.
Corley SM, Mendoza-Reinoso V, Giles N, Singer ES, Common JE, Wilkins MR, Beverdam A., Free PMC Article | 12/14/2019 |
| TGFBR3 (betaglycan) functions as an inhibin A, but not an inhibin B, coreceptor in gonadotrope cells in vivo. Mechanisms of inhibin B action merit further investigation. | Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice.
Li Y, Fortin J, Ongaro L, Zhou X, Boehm U, Schneyer A, Bernard DJ, Lin HY., Free PMC Article | 05/11/2019 |
| TGFbetaR3 promotes apoptosis of cardiomyocytes via a p38 pathway-associated mechanism, and loss of TGFbetaR3 reduces myocardial infarction injury. | Transforming Growth Factor-β Receptor III is a Potential Regulator of Ischemia-Induced Cardiomyocyte Apoptosis.
Sun F, Li X, Duan WQ, Tian W, Gao M, Yang J, Wu XY, Huang D, Xia W, Han YN, Wang JX, Liu YX, Dong CJ, Zhao D, Ban T, Chu WF., Free PMC Article | 03/31/2018 |
| BMP2 also requires Src for filamentous actin polymerization in Tgfbr3(-/-) epicardial cells. | BMP2 rescues deficient cell migration in Tgfbr3(-/-) epicardial cells and requires Src kinase.
Allison P, Espiritu D, Camenisch TD., Free PMC Article | 12/2/2017 |
| describe a detailed characterization of TbetaRIII expression in lymphocyte subpopulations demonstrating that this co-receptor is significantly expressed in T but not B lymphocytes and among them, preferentially expressed on naive and central memory T cells | TβRIII is induced by TCR signaling and downregulated in FoxP3(+) regulatory T cells.
Ortega-Francisco S, de la Fuente-Granada M, Alvarez Salazar EK, Bolaños-Castro LA, Fonseca-Camarillo G, Olguin-Alor R, Alemán-Muench GR, López-Casillas F, Raman C, García-Zepeda EA, Soldevila G. | 11/18/2017 |
| Study identified a novel major binding site for TGF-beta-like growth factors in TGFR-3. Findings potentially provide novel experimental insight into the general function of zona pellucida domain-containing proteins. | Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3).
Diestel U, Resch M, Meinhardt K, Weiler S, Hellmann TV, Mueller TD, Nickel J, Eichler J, Muller YA., Free PMC Article | 10/21/2017 |
| a signaling pathway important in epicardial cell behavior downstream of TGFbetaR3 | Transcriptional Profiling of Cultured, Embryonic Epicardial Cells Identifies Novel Genes and Signaling Pathways Regulated by TGFβR3 In Vitro.
DeLaughter DM, Clark CR, Christodoulou DC, Seidman CE, Baldwin HS, Seidman JG, Barnett JV., Free PMC Article | 08/5/2017 |
| Retinoic acid enhanced TbetaRIII expression and that this increase contributed to LF-stimulated IgA production. | Retinoic acid enhances lactoferrin-induced IgA responses by increasing betaglycan expression.
Lee JM, Jang YS, Jin BR, Kim SJ, Kim HJ, Kwon BE, Ko HJ, Yoon SI, Lee GS, Kim WS, Seo GY, Kim PH., Free PMC Article | 07/15/2017 |
| Pro-fibrotic cardiac effect of miR-328 was mediated by down-regulating TGFbR3 and up-regulating TGFb1. | MicroRNA-328, a Potential Anti-Fibrotic Target in Cardiac Interstitial Fibrosis.
Du W, Liang H, Gao X, Li X, Zhang Y, Pan Z, Li C, Wang Y, Liu Y, Yuan W, Ma N, Chu W, Shan H, Lu Y. | 02/4/2017 |
| These data reveal a critical, previously unrecognized role for TGFbetaR3 in vascular and osteoblast development during palatogenesis. | Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.
Hill CR, Jacobs BH, Brown CB, Barnett JV, Goudy SL., Free PMC Article | 07/25/2015 |
| These data demonstrate that TbetaRIII regulates BMP-mediated signaling and biological effects, primarily through the ligand sequestration effects of sTbetaRIII in normal and cancerous mammary epithelial cells. | The balance of cell surface and soluble type III TGF-β receptor regulates BMP signaling in normal and cancerous mammary epithelial cells.
Gatza CE, Elderbroom JL, Oh SY, Starr MD, Nixon AB, Blobe GC., Free PMC Article | 04/4/2015 |
| Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-beta signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts. | Glucocorticoids recruit Tgfbr3 and Smad1 to shift transforming growth factor-β signaling from the Tgfbr1/Smad2/3 axis to the Acvrl1/Smad1 axis in lung fibroblasts.
Schwartze JT, Becker S, Sakkas E, Wujak ŁA, Niess G, Usemann J, Reichenberger F, Herold S, Vadász I, Mayer K, Seeger W, Morty RE., Free PMC Article | 04/12/2014 |
| work reveals a 'seed and soil' mechanism where TGF-beta2 and TGF-beta-RIII signalling through p38alpha/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis | TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling.
Bragado P, Estrada Y, Parikh F, Krause S, Capobianco C, Farina HG, Schewe DM, Aguirre-Ghiso JA., Free PMC Article | 01/18/2014 |
| TGFBR3 mediated suppression of cancer progression includes effects on the tumor immune microenvironment. | Type III TGF-β receptor downregulation generates an immunotolerant tumor microenvironment.
Hanks BA, Holtzhausen A, Evans KS, Jamieson R, Gimpel P, Campbell OM, Hector-Greene M, Sun L, Tewari A, George A, Starr M, Nixon AB, Augustine C, Beasley G, Tyler DS, Osada T, Morse MA, Ling L, Lyerly HK, Blobe GC., Free PMC Article | 11/30/2013 |
| Loss of Tgfbr3 compromises the functions of TGFbeta2 in the differentiating fetal testis. | Effects of TGFbeta2 on wild-type and Tgfbr3 knockout mouse fetal testis.
Sarraj MA, Escalona RM, Western P, Findlay JK, Stenvers KL. | 09/21/2013 |
| A novel reciprocal loop between miR-21 and TGFbetaRIII in cardiac fibrosis caused by myocardial infarction in mice. | A novel reciprocal loop between microRNA-21 and TGFβRIII is involved in cardiac fibrosis.
Liang H, Zhang C, Ban T, Liu Y, Mei L, Piao X, Zhao D, Lu Y, Chu W, Yang B. | 04/27/2013 |
| These data suggest that Inhibins and TbetaRIII may function as a molecular pair regulating T cell development. | Betaglycan (TβRIII) is expressed in the thymus and regulates T cell development by protecting thymocytes from apoptosis.
Aleman-Muench GR, Mendoza V, Stenvers K, Garcia-Zepeda EA, Lopez-Casillas F, Raman C, Soldevila G., Free PMC Article | 02/9/2013 |
| the relative roles of TGFbetaR3-dependent and -independent signaling in the actions of BMP2 on epicardial cell behavior and demonstrate the critical role of TGFbetaR3 in mediating BMP2-stimulated invasion. | BMP2 signals loss of epithelial character in epicardial cells but requires the Type III TGFβ receptor to promote invasion.
Hill CR, Sanchez NS, Love JD, Arrieta JA, Hong CC, Brown CB, Austin AF, Barnett JV., Free PMC Article | 06/9/2012 |
| used intact embryos and epicardial cells from E11.5 mouse embryos to reveal the mechanisms by which TGFbetaR3 signals and regulates epicardial cell behavior | The cytoplasmic domain of TGFβR3 through its interaction with the scaffolding protein, GIPC, directs epicardial cell behavior.
Sánchez NS, Hill CR, Love JD, Soslow JH, Craig E, Austin AF, Brown CB, Czirok A, Camenisch TD, Barnett JV., Free PMC Article | 11/26/2011 |
| TGFBR3 can prevent hypoxia-induced injury in neonatal mice cardiac fibroblasts by negative regulation of TGF-beta signaling. | TGFBR3, a potential negative regulator of TGF-β signaling, protects cardiac fibroblasts from hypoxia-induced apoptosis.
Chu W, Li X, Li C, Wan L, Shi H, Song X, Liu X, Chen X, Zhang C, Shan H, Lu Y, Yang B. | 10/15/2011 |
| Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch. | Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding.
Lin SJ, Hu Y, Zhu J, Woodruff TK, Jardetzky TS., Free PMC Article | 06/18/2011 |