| Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract. | Let-7c-3p suppresses lens epithelial-mesenchymal transition by inhibiting cadherin-11 expression in fibrotic cataract.
Hou M, Luo F, Ding Y, Bao X, Chen X, Liu L, Wu M. | 04/17/2024 |
| The Research Progress in Transforming Growth Factor-beta2. | The Research Progress in Transforming Growth Factor-β2.
Wang MY, Liu WJ, Wu LY, Wang G, Zhang CL, Liu J., Free PMC Article | 04/2/2024 |
| miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFbeta2 signaling pathway. | miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGFβ2 signaling pathway.
Yang Z, Yang L, Sun Z, Rong Y, Bai C, Dong Q, Jian L., Free PMC Article | 11/22/2023 |
| TGFbeta-2 haploinsufficiency causes early death in mice with Marfan syndrome. | TGFβ-2 haploinsufficiency causes early death in mice with Marfan syndrome.
Sachan N, Phoon CKL, Zilberberg L, Kugler MC, Ene T, Mintz SB, Murtada SI, Weiss D, Fishman GI, Humphrey JD, Rifkin DB., Free PMC Article | 09/8/2023 |
| TGF-beta2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma. | TGF-β2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma.
Lee HK, Nam MW, Go RE, Koo J, Kim TH, Park JE, Choi KC. | 02/25/2023 |
| Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-beta1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice. | Neonatal inflammation increases hippocampal KCC2 expression through methylation-mediated TGF-β1 downregulation leading to impaired hippocampal cognitive function and synaptic plasticity in adult mice.
Rong J, Yang Y, Liang M, Zhong H, Li Y, Zhu Y, Sha S, Chen L, Zhou R., Free PMC Article | 02/4/2023 |
| TGF-beta2 Regulates Transcription of the K[+]/Cl[-] Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons. | TGF-β2 Regulates Transcription of the K(+)/Cl(-) Cotransporter 2 (KCC2) in Immature Neurons and Its Phosphorylation at T1007 in Differentiated Neurons.
Rigkou A, Magyar A, Speer JM, Roussa E., Free PMC Article | 12/31/2022 |
| Oocyte-secreted factor TGFB2 enables mouse cumulus cell expansion in vitro. | Oocyte-secreted factor TGFB2 enables mouse cumulus cell expansion in vitro.
Hao X, Yuan F, Cui Y, Zhang M. | 12/3/2022 |
| TFPI2 suppresses the interaction of TGF-beta2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy. | TFPI2 suppresses the interaction of TGF-β2 pathway regulators to promote endothelial-mesenchymal transition in diabetic nephropathy.
Guan G, Xie J, Dai Y, Han H., Free PMC Article | 04/30/2022 |
| TGFbeta2 Induces the Soluble Isoform of CTLA-4 - Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma. | TGFβ2 Induces the Soluble Isoform of CTLA-4 - Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma.
Khanolkar RC, Zhang C, Al-Fatyan F, Lawson L, Depasquale I, Meredith FM, Muller F, Nicolson M, Dahal LN, Abu-Eid R, Rajpara S, Barker RN, Ormerod AD, Ward FJ., Free PMC Article | 02/26/2022 |
| Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFbeta2 Induced Primary Open Angle Glaucoma. | Astragaloside IV Attenuates Ocular Hypertension in a Mouse Model of TGFβ2 Induced Primary Open Angle Glaucoma.
Kasetti RB, Maddineni P, Kodati B, Nagarajan B, Yacoub S., Free PMC Article | 12/18/2021 |
| Diverse Signaling by TGFbeta Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis. | Diverse Signaling by TGFβ Isoforms in Response to Focal Injury is Associated with Either Retinal Regeneration or Reactive Gliosis.
Conedera FM, Quintela Pousa AM, Presby DM, Mercader N, Enzmann V, Tschopp M., Free PMC Article | 08/14/2021 |
| TGF-beta2 interfering oligonucleotides used as adjuvants for microbial vaccines. | TGF-β2 interfering oligonucleotides used as adjuvants for microbial vaccines.
Tu L, Sun X, Yang L, Zhang T, Zhang X, Li X, Dong B, Liu Y, Yang M, Wang L, Yu Y. | 02/13/2021 |
| results indicated miR-378a impairs tenogenic differentiation and tendon repair by inhibition collagen and extracellular matrix production both in vitro and in vivo. We also demonstrated that miR-378a exert its inhibitory role during tenogenic differentiation through binding at TGFbeta2 by luciferase reporter assay and western blot. | MiR-378a suppresses tenogenic differentiation and tendon repair by targeting at TGF-β2.
Liu Y, Feng L, Xu J, Yang Z, Wu T, Zhang J, Shi L, Zhu D, Zhang J, Li G., Free PMC Article | 06/27/2020 |
| Tgfb2 and Fam220a were identified as putative targets of miR-489-3p and miR-92a-3p, respectively; inhibition endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis | Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis.
Wiese CB, Zhong J, Xu ZQ, Zhang Y, Ramirez Solano MA, Zhu W, Linton MF, Sheng Q, Kon V, Vickers KC., Free PMC Article | 05/16/2020 |
| The synergistic effects of TGFbeta2, WNT9a, and FGFR4 were responsible for attenuating of the differentiation of aging satellite cells during skeletal muscle development. | Synergistic effects of TGFβ2, WNT9a, and FGFR4 signals attenuate satellite cell differentiation during skeletal muscle development.
Zhang W, Xu Y, Zhang L, Wang S, Yin B, Zhao S, Li X., Free PMC Article | 10/12/2019 |
| The current study demonstrates for the first time a new role for miRNA-466a-3p and TGF-beta2 in the regulation of Treg differentiation and thus offers novel avenues to control inflammatory disorders. | miR-466a Targeting of TGF-β2 Contributes to FoxP3(+) Regulatory T Cell Differentiation in a Murine Model of Allogeneic Transplantation.
Becker W, Nagarkatti M, Nagarkatti PS., Free PMC Article | 06/8/2019 |
| identify the BGZP-C-binding site on TGF-beta2 and shed light on the specificity of BG for select TGF-beta-type GFs and the mechanisms by which BG influences their signaling | TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
Henen MA, Mahlawat P, Zwieb C, Kodali RB, Hinck CS, Hanna RD, Krzysiak TC, Ilangovan U, Cano KE, Hinck G, Vonberg M, McCabe M, Hinck AP., Free PMC Article | 05/11/2019 |
| High Tgfb2 expression is associated with ocular hypertension. | Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension.
Kasetti RB, Maddineni P, Patel PD, Searby C, Sheffield VC, Zode GS., Free PMC Article | 01/26/2019 |
| Study points toward elevated levels of active TGF-beta as inducers and promoters of ectopic bone formation, and suggest that TGF-beta might be a therapeutic target in heterotopic ossification. | Inhibition of overactive TGF-β attenuates progression of heterotopic ossification in mice.
Wang X, Li F, Xie L, Crane J, Zhen G, Mishina Y, Deng R, Gao B, Chen H, Liu S, Yang P, Gao M, Tu M, Wang Y, Wan M, Fan C, Cao X., Free PMC Article | 12/22/2018 |
| data suggest a mechanism whereby a stromal hedgehog-TGFbeta2 signaling axis acts to control nephrogenesis. | Hedgehog-GLI signaling in Foxd1-positive stromal cells promotes murine nephrogenesis via TGFβ signaling.
Rowan CJ, Li W, Martirosyan H, Erwood S, Hu D, Kim YK, Sheybani-Deloui S, Mulder J, Blake J, Chen L, Rosenblum ND. | 08/4/2018 |
| Data show that just like TGF-beta1, TGF-beta2 is expressed in and secreted by both, healthy and diseased hepatocytes and hepatic stellate cell (HSCs). | TGF-β1 and TGF-β2 abundance in liver diseases of mice and men.
Dropmann A, Dediulia T, Breitkopf-Heinlein K, Korhonen H, Janicot M, Weber SN, Thomas M, Piiper A, Bertran E, Fabregat I, Abshagen K, Hess J, Angel P, Coulouarn C, Dooley S, Meindl-Beinker NM., Free PMC Article | 12/2/2017 |
| TGF-beta2 as the crucial mediator of neural precursor cell immunomodulation. | Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity.
De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, Srinivasan S, Farina C, Garcia Manteiga JM, Butti E, Bacigaluppi M, Comi G, Greter M, Martino G., Free PMC Article | 11/25/2017 |
| CREBH was identified as a key positive regulator of TGF-beta2 transcription in hepatitis C virus-infected cells. | Critical role of CREBH-mediated induction of transforming growth factor β2 by hepatitis C virus infection in fibrogenic responses in hepatic stellate cells.
Chida T, Ito M, Nakashima K, Kanegae Y, Aoshima T, Takabayashi S, Kawata K, Nakagawa Y, Yamamoto M, Shimano H, Matsuura T, Kobayashi Y, Suda T, Suzuki T. | 11/4/2017 |
| RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells | Endothelial angiogenesis is directed by RUNX1T1-regulated VEGFA, BMP4 and TGF-β2 expression.
Liao KH, Chang SJ, Chang HC, Chien CL, Huang TS, Feng TC, Lin WW, Shih CC, Yang MH, Yang SH, Lin CH, Hwang WL, Lee OK., Free PMC Article | 09/23/2017 |