| Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration. | Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration.
Byrnes JR, Lee T, Sharaby S, Campbell RA, Dobson DA, Holle LA, Luo M, Kangro K, Homeister JW, Aleman MM, Luyendyk JP, Kerlin BA, Dumond JB, Wolberg AS., | 02/6/2024 |
| Role, Laboratory Assessment and Clinical Relevance of Fibrin, Factor XIII and Endogenous Fibrinolysis in Arterial and Venous Thrombosis. | Role, Laboratory Assessment and Clinical Relevance of Fibrin, Factor XIII and Endogenous Fibrinolysis in Arterial and Venous Thrombosis.
Memtsas VP, Arachchillage DRJ, Gorog DA., Free PMC Article | 04/17/2021 |
| investigations show no effect of FXIII-B subunit on the rate of complement activation | Exploring the structural similarity yet functional distinction between coagulation factor XIII-B and complement factor H sushi domains.
Akhter MS, Singh S, Yadegari H, Ivaskevicius V, Oldenburg J, Biswas A. | 12/21/2019 |
| Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients | Effect of factor XIII levels and polymorphisms on the risk of myocardial infarction in young patients.
Balogh L, Katona É, Mezei ZA, Kállai J, Gindele R, Édes I, Muszbek L, Papp Z, Bereczky Z. | 11/3/2018 |
| In VTE patients the changes of FXIII level and their effect on the risk of VTE show considerable sex-specific differences. Intron K polymorphism results in decreased FXIII levels, but does not influence the risk of VTE. | Factor XIII levels and factor XIII B subunit polymorphisms in patients with venous thromboembolism.
Mezei ZA, Katona É, Kállai J, Bereczky Z, Somodi L, Molnár É, Kovács B, Miklós T, Ajzner É, Muszbek L. | 08/11/2018 |
| These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations. | The interaction between fibrinogen and zymogen FXIII-A2B2 is mediated by fibrinogen residues γ390-396 and the FXIII-B subunits.
Byrnes JR, Wilson C, Boutelle AM, Brandner CB, Flick MJ, Philippou H, Wolberg AS., Free PMC Article | 08/5/2017 |
| The results suggest that plasma FXIII levels are subjected to multifactorial regulation with age, fibrinogen level and FXIII-B intron K polymorphism being the major determinants. Their effect on FXIII levels might influence the risk of thrombotic diseases. | Regulation of plasma factor XIII levels in healthy individuals; a major impact by subunit B intron K c.1952+144 C>G polymorphism.
Mezei ZA, Katona É, Kállai J, Bereczky Z, Molnár É, Kovács B, Ajzner É, Bagoly Z, Miklós T, Muszbek L. | 04/22/2017 |
| The Val34Leu polymorphism of FXIII was not found in Korean people, and compared with Caucasians, a noticeably low incidence of deep vein thrombosis was shown. | Prevalence of the Factor XIII Val34Leu Polymorphism in Korean Patients with Deep Vein Thrombosis.
Kim SD, Hwang JK, Park SC, Kim JI, Won YS, Yun SS, Moon IS, Park JS. | 12/17/2016 |
| Genetic markers associated with low FXIIIB levels increase risk of ischemic stroke cardioembolic subtype. | Genetic Factors Influencing Coagulation Factor XIII B-Subunit Contribute to Risk of Ischemic Stroke.
Hanscombe KB, Traylor M, Hysi PG, Bevan S, Dichgans M, Rothwell PM, Worrall BB, Seshadri S, Sudlow C, METASTROKE Consortium, Wellcome Trust Case Control Consortium 2, Williams FM, Markus HS, Lewis CM., Free PMC Article | 10/24/2015 |
| The FXIII-B intron K nt29756 G allele was associated with significant protection against CAS and MI in patients with a fibrinogen level in the upper tertile. | Factor XIII B subunit polymorphisms and the risk of coronary artery disease.
Mezei ZA, Bereczky Z, Katona É, Gindele R, Balogh E, Fiatal S, Balogh L, Czuriga I, Ádány R, Édes I, Muszbek L., Free PMC Article | 09/26/2015 |
| Changes in plasma levels of FXIIIB are associated with cognitive decline in the elderly. | High Levels of Antifibrinolytic Proteins Are Found in Plasma of Older Octogenarians With Cardiovascular Disease and Cognitive Decline.
Cubedo J, Padró T, Peña E, Aledo R, Formiga F, Ferrer A, Padrós G, Badimon L. | 09/12/2015 |
| Here, we update the knowledge about the pathophysiology of factor XIII deficiency and its therapeutic options. [review] | Coagulation factor XIII deficiency. Diagnosis, prevalence and management of inherited and acquired forms.
Biswas A, Ivaskevicius V, Thomas A, Oldenburg J. | 04/4/2015 |
| Data suggest that Factor XIII (composed of subunits F13A and F13B) increases rigidity/strength of fibrin clot, protects fibrin clot against shear stress in circulation, and protects fibrin from prompt elimination by fibrinolytic system. [REVIEW] | Factor XIII: congenital deficiency factor XIII, acquired deficiency, factor XIII A-subunit, and factor XIII B-subunit.
Tahlan A, Ahluwalia J. | 04/5/2014 |
| Case Report: congenital FXIII-B deficiency in which alloantibodies developed to exogenous FXIII-B. | Alloantibodies against the B subunit of plasma factor XIII developed in its congenital deficiency.
Wada H, Souri M, Matsumoto R, Sugihara T, Ichinose A. | 11/16/2013 |
| Factor XIII levels are decreased in Crohn's disease patients, but did not correlate with the time course of disease evolution, CRP, serum fibrin levels, platelet count, disease distribution within the bowel, or the presence of a fistulising form. | The usefulness of factor XIII levels in Crohn's disease.
Cougard PA, Desjeux A, Vitton V, Baumstarck-Barrau K, Lesavre N, Grimaud JC. | 01/26/2013 |
| Letter: suggest that recurrent pregnancy loss in the general population is not associated with reduced FXIII plasma levels. | Factor XIII plasma levels in women with unexplained recurrent pregnancy loss.
Pasquier E, De Saint Martin L, Kohler HP, Schroeder V. | 09/1/2012 |
| A review analyzes and present an exhaustive amount of F13B mutational data from the past three decades. | An update of the mutation profile of Factor 13 A and B genes.
Biswas A, Ivaskevicius V, Seitz R, Thomas A, Oldenburg J. | 12/10/2011 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| FXIIIb subunit is found to be within normal range in eight Tunisian famillies with congenital factor XIII deficiency caused by two mutations, while expression of the FXIIIA subunit gene is decreased or undetectable. | Congenital factor XIII deficiency caused by two mutations in eight Tunisian families: molecular confirmation of a founder effect.
Louhichi N, Medhaffar M, Hadjsalem I, Mkaouar-Rebai E, Fendri-Kriaa N, Kanoun H, Yaïch F, Souissi T, Elloumi M, Fakhfakh F. | 04/19/2010 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and genetic testing. (HuGE Navigator) | Integrative predictive model of coronary artery calcification in atherosclerosis.
McGeachie M, Ramoni RL, Mychaleckyj JC, Furie KL, Dreyfuss JM, Liu Y, Herrington D, Guo X, Lima JA, Post W, Rotter JI, Rich S, Sale M, Ramoni MF., Free PMC Article | 04/7/2010 |
| Develop ELISA/chemoluminescence assay demonstrating that FXIII-A and FXIII-B are low concentration components of tear proteome. | A highly sensitive chemiluminescence immunoassay for the measurement of coagulation factor XIII subunits and their complex in tears.
Orosz ZZ, Katona E, Facskó A, Berta A, Muszbek L. | 03/15/2010 |
| A specific colorimetric assay for measuring FXIIIB activity is reported. | A specific colorimetric assay for measuring transglutaminase 1 and factor XIII activities.
Hitomi K, Kitamura M, Alea MP, Ceylan I, Thomas V, El Alaoui S. | 01/21/2010 |
| at least 3 out of the 10 Sushi domains of FXIII-B have the distinct function of forming a homodimer and a heterotetramer, which should be ascribed to the differences in their amino acid sequences | Sushi domains in the B subunit of factor XIII responsible for oligomer assembly.
Souri M, Kaetsu H, Ichinose A. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (14) articlesAn integrative method for scoring candidate genes from association studies: application to warfarin dosing.
Tatonetti NP, Dudley JT, Sagreiya H, Butte AJ, Altman RB. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).
Romero R, Friel LA, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Erez O, Chaiworapongsa T, Pearce BD, Bartlett J, Salisbury BA, Anant MK, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R. Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.
Romero R, Velez Edwards DR, Kusanovic JP, Hassan SS, Mazaki-Tovi S, Vaisbuch E, Kim CJ, Chaiworapongsa T, Pearce BD, Friel LA, Bartlett J, Anant MK, Salisbury BA, Vovis GF, Lee MS, Gomez R, Behnke E, Oyarzun E, Tromp G, Williams SM, Menon R. New genetic associations detected in a host response study to hepatitis B vaccine.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium. Genes influencing coagulation and the risk of aneurysmal subarachnoid hemorrhage, and subsequent complications of secondary cerebral ischemia and rebleeding.
Ruigrok YM, Slooter AJ, Rinkel GJ, Wijmenga C, Rosendaal FR. Candidate gene polymorphisms for ischemic stroke.
Matarin M, Brown WM, Dena H, Britton A, De Vrieze FW, Brott TG, Brown RD Jr, Worrall BB, Case LD, Chanock SJ, Metter EJ, Ferrucci L, Gamble D, Hardy JA, Rich SS, Singleton A, Meschia JF. Genetic variants of coagulation factor XIII and the risk of myocardial infarction in young women.
Siegerink B, Algra A, Rosendaal FR. Prothrombotic genetic variants and atherosclerosis in patients with cerebral ischemia of arterial origin.
Pruissen DM, Kappelle LJ, Rosendaal FR, Algra A, SMART Study Group. The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.
Zhang H, Morrison MA, Dewan A, Adams S, Andreoli M, Huynh N, Regan M, Brown A, Miller JW, Kim IK, Hoh J, Deangelis MM. Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke.
Pruissen DM, Slooter AJ, Rosendaal FR, van der Graaf Y, Algra A. An interactive association of common sequence variants in the neuropeptide Y gene with susceptibility to ischemic stroke.
Lee C, Kong M. A novel polymorphism in the factor XIII B-subunit (His95Arg): relationship to subunit dissociation and venous thrombosis.
Komanasin N, Catto AJ, Futers TS, van Hylckama Vlieg A, Rosendaal FR, Ariëns RA. | 03/13/2008 |
| Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator) | See all PubMed (2) articlesFactor XIIIA-V34L and factor XIIIB-H95R gene variants: effects on survival in myocardial infarction patients.
Gemmati D, Federici F, Campo G, Tognazzo S, Serino ML, De Mattei M, Valgimigli M, Malagutti P, Guardigli G, Ferraresi P, Bernardi F, Ferrari R, Scapoli GL, Catozzi L. Genetic variants of coagulation factor XIII, postmenopausal estrogen therapy, and risk of nonfatal myocardial infarction.
Reiner AP, Heckbert SR, Vos HL, Ariëns RA, Lemaitre RN, Smith NL, Lumley T, Rea TD, Hindorff LA, Schellenbaum GD, Rosendaal FR, Siscovick DS, Psaty BM. | 03/13/2008 |