| A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus. | A loss of function mutation in SOCS2 results in increased inflammatory response of macrophages to TLR ligands and Staphylococcus aureus.
Guzylack-Piriou L, Gausseres B, Tasca C, Hassel C, Tabouret G, Foucras G., Free PMC Article | 10/4/2024 |
| Mutation of SOCS2 induces structural and functional changes in mammary development. | Mutation of SOCS2 induces structural and functional changes in mammary development.
Ivanova E, Hue-Beauvais C, Castille J, Laubier J, Le Guillou S, Aujean E, Lecardonnel J, Lebrun L, Jaffrezic F, Rousseau-Ralliard D, Péchoux C, Letheule M, Foucras G, Charlier M, Le Provost F. | 03/21/2024 |
| SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease. | SOCS2 regulates alveolar bone loss in Aggregatibacter actinomycetemcomitans-induced periodontal disease.
Santos MRG, Chaves IM, Queiroz-Junior CM, Cramer AT, Anestino TA, Dos Santos ACPM, Leite PG, Macari S, Barrioni BR, Pereira MM, Teixeira MM, de Souza DDG, Madeira MFM, Machado FS. | 04/28/2023 |
| SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine. | SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.
Li K, Meza Guzman LG, Whitehead L, Leong E, Kueh A, Alexander WS, Kershaw NJ, Babon JJ, Doggett K, Nicholson SE., Free PMC Article | 12/24/2022 |
| Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation. | Epigenetic downregulation of Socs2 contributes to mutant N-Ras-mediated hematopoietic dysregulation.
Jin X, Ng V, Zhao M, Liu L, Higashimoto T, Lee ZH, Chung J, Chen V, Ney G, Kandarpa M, Talpaz M, Li Q., Free PMC Article | 05/21/2022 |
| Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis. | Role of Suppressor of cytokine signaling 2 during the development and resolution of an experimental arthritis.
Cramer A, Galvão I, Venturini de Sá N, Gaio P, Fernanda de Melo Oliveira N, Rates Gonzaga Santos M, Henrique Campolina-Silva G, Vinicius Santos Valiate B, Rezende Souza F, Dantas Cassali G, Martins Teixeira M, Almeida Amaral F, Simão Machado F. | 03/5/2022 |
| SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection: Correlation with immune response and cardiac dysfunction. | SOCS2 expression in hematopoietic and non-hematopoietic cells during Trypanosoma cruzi infection: Correlation with immune response and cardiac dysfunction.
Gaio P, Gualdrón-López M, Cramer A, Esper L, de Menezes Filho JER, Cruz JS, Teixeira MM, Machado FS. | 02/26/2022 |
| MiR-129-5p alleviates myocardial injury by targeting suppressor of cytokine signaling 2 after ischemia/reperfusion. | MiR-129-5p alleviates myocardial injury by targeting suppressor of cytokine signaling 2 after ischemia/reperfusion.
Ma R, Chen X, Ma Y, Bai G, Li DS. | 10/9/2021 |
| Suppressor of cytokine signaling 2 is induced in Huntington's disease and involved in autophagy. | Suppressor of cytokine signaling 2 is induced in Huntington's disease and involved in autophagy.
Cho K, Kim S, Choi SH. | 08/28/2021 |
| SOCS2 Silencing Improves Somatic Growth without Worsening Kidney Function in CKD. | SOCS2 Silencing Improves Somatic Growth without Worsening Kidney Function in CKD.
Landau D, Assadi MH, Abu Hilal R, Chen Y, Rabkin R, Segev Y. | 07/24/2021 |
| CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures. | CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures.
Xiaoying G, Guo M, Jie L, Yanmei Z, Ying C, Shengjie S, Haiyan G, Feixiang S, Sihua Q, Jiahang S., Free PMC Article | 06/19/2021 |
| SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes. | SOCS2 Inhibits Mitochondrial Fatty Acid Oxidation via Suppressing LepR/JAK2/AMPK Signaling Pathway in Mouse Adipocytes.
Zhang T, Chen Y, Cai J, Pan M, Sun Q, Zhang J, Sun C., Free PMC Article | 05/15/2021 |
| Neuroinflammation is associated with reduced SOCS2 and SOCS3 expression during intracranial HSV-1 infection. | Neuroinflammation is associated with reduced SOCS2 and SOCS3 expression during intracranial HSV-1 infection.
Toscano ECB, Sousa LFDC, Lima GK, Mesquita LA, Vilela MC, Rodrigues DH, Ferreira RN, Soriani FM, Campos MA, Kroon EG, Teixeira MM, de Miranda AS, Rachid MA, Teixeira AL. | 05/1/2021 |
| SOCS2 modulates adipose tissue inflammation and expansion in mice. | SOCS2 modulates adipose tissue inflammation and expansion in mice.
Val CH, de Oliveira MC, Lacerda DR, Barroso A, Batista NV, Menezes-Garcia Z, de Assis DRR, Cramer AT, Brant F, Teixeira MM, Glória Souza D, Ferreira AM, Machado FS. | 02/13/2021 |
| our data suggest a novel role for SOCS2 in interacting with and regulating the trafficking of TrkB, leading to increased neurite outgrowth in hippocampus neurons. | Tropomyosin-Related Kinase B (TrkB) Regulates Neurite Outgrowth via a Novel Interaction with Suppressor of Cytokine Signalling 2 (SOCS2).
Zamani A, Xiao J, Turnley AM, Murray SS. | 07/13/2019 |
| SOCS2 negatively regulates the development of natural killer cells by inhibiting JAK2 activity via direct interaction. | Suppressor of Cytokine Signaling 2 Negatively Regulates NK Cell Differentiation by Inhibiting JAK2 Activity.
Kim WS, Kim MJ, Kim DO, Byun JE, Huy H, Song HY, Park YJ, Kim TD, Yoon SR, Choi EJ, Jung H, Choi I., Free PMC Article | 12/1/2018 |
| the absence of SOCS2 is protective against bone loss typical of inflammatory bowel disease. | Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.
Dobie R, MacRae VE, Pass C, Milne EM, Ahmed SF, Farquharson C., Free PMC Article | 10/13/2018 |
| SOCS2 deletion had no effect on total dendrite length, number of dendritic segments, number of branch points or total dendritic spine density but increased the number of mature "mushroom" spines. | Suppressor of Cytokine Signalling 2 (SOCS2) Regulates Numbers of Mature Newborn Adult Hippocampal Neurons and Their Dendritic Spine Maturation.
Basrai HS, Turbic A, Christie KJ, Turnley AM. | 02/24/2018 |
| The induction of a tolerogenic phenotype in DCs by NPs was mediated by the AhR-dependent induction of Socs2, which resulted in inhibition of nuclear factor kappaB activation and proinflammatory cytokine production (properties of tolerogenic DCs). | Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.
Yeste A, Takenaka MC, Mascanfroni ID, Nadeau M, Kenison JE, Patel B, Tukpah AM, Babon JA, DeNicola M, Kent SC, Pozo D, Quintana FJ. | 11/26/2017 |
| Upon deletion of the STAT5 response elements from the Socs2 promoter in mice, cytokine induction was abrogated, while basal activity remained intact. Our data suggest that promoter-bound STAT5 modulates cytokine responses and enhancer-bound STAT5 is mandatory for gene activation. | Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5.
Zeng X, Willi M, Shin HY, Hennighausen L, Wang C., Free PMC Article | 11/25/2017 |
| In a knockout mouse model, deficiency of SOCS2 was associated with decreased neuroinflammation and increased survival following HSV-1 infection, without significant effect on viral load. This result indicates that SOCS2 plays a major role in driving neuroinflammation and subsequent brain damage during HSV-1 encephalitis. | Suppressor of cytokine signaling 2 (SOCS2) contributes to encephalitis in a model of Herpes infection in mice.
da Cunha Sousa LF, Rachid MA, Lima GK, de Miranda AS, de Carvalho Vilela M, Lacerda Queiroz N, Rodrigues DH, Campos MA, Kroon EG, Machado FS, Teixeira AL. | 11/18/2017 |
| Our data show that absence of SOCS2 turns cardiomyocytes unresponsive to LIF-induced [Ca(2+)] raise, indicating that endogenous levels of SOCS2 are crucial for full activation of LIF signaling in the heart. | Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca(2+) levels.
Rocha-Resende C, Guedes de Jesus IC, Roman-Campos D, Miranda AS, Alves F, Resende RR, Dos Santos Cruz J, Machado FS, Guatimosim S. | 06/10/2017 |
| Knockdown of SOCS2 makes mice less sensitive to multiple low dose streptozotocin. | Suppressor of cytokine signaling 2 (SOCS2) deletion protects against multiple low dose streptozotocin-induced type 1 diabetes in adult male mice.
Alkharusi A, Mirecki-Garrido M, Ma Z, Zadjali F, Flores-Morales A, Nyström T, Castrillo A, Bjorklund A, Norstedt G, Fernandez-Pérez L. | 03/11/2017 |
| Study provides an insight into the role of SOCS2 in modulating the immune response to Bovine herpesvirus 5 [BoHV-5]infection. | Role of the suppressor of cytokine signaling 2 (SOCS2) during meningoencephalitis caused by Bovine herpesvirus 5 (BoHV-5).
Aparecida Silva Barbosa A, Freitas Versiani A, Fonseca da Cunha Sousa L, Silva de Miranda A, Gasparini MR, Brant F, Silva DG, Luisa Quintino-de-Carvalho I, Marianetti Soriani F, Guimarães da Fonseca F, César Vasconcelos A, da Silva Barcelos L, Martins Teixeira M, Lúcio Teixeira A, Machado FS, Barbosa-Stancioli EF, Rachid MA. | 01/28/2017 |
| Data (including data from studies in knockout mice) suggest Socs2 regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor) level via ubiquitination/proteolysis, and serum Igf1 (insulin-like growth factor-1) level. | SOCS2 Balances Metabolic and Restorative Requirements during Liver Regeneration.
Masuzaki R, Zhao S, Valerius MT, Tsugawa D, Oya Y, Ray KC, Karp SJ., Free PMC Article | 07/16/2016 |