| Intestinal Epithelial Inactivity of Dual Oxidase 2 Results in Microbiome-Mediated Metabolic Syndrome. | Intestinal Epithelial Inactivity of Dual Oxidase 2 Results in Microbiome-Mediated Metabolic Syndrome.
Hazime H, Ducasa GM, Santander AM, Brito N, González EE, Ban Y, Kaunitz J, Akiba Y, Fernández I, Burgueño JF, Abreu MT., Free PMC Article | 09/25/2023 |
| Telocytes reduce oxidative stress by downregulating DUOX2 expression in inflamed lungs of mice. | Telocytes reduce oxidative stress by downregulating DUOX2 expression in inflamed lungs of mice.
Tang H, Liang T, Zhou Y, Ju H, Song D, Fang H., Free PMC Article | 05/28/2022 |
| DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk. | DUOX2 variants associate with preclinical disturbances in microbiota-immune homeostasis and increased inflammatory bowel disease risk.
Grasberger H, Magis AT, Sheng E, Conomos MP, Zhang M, Garzotto LS, Hou G, Bishu S, Nagao-Kitamoto H, El-Zaatari M, Kitamoto S, Kamada N, Stidham RW, Akiba Y, Kaunitz J, Haberman Y, Kugathasan S, Denson LA, Omenn GS, Kao JY., Free PMC Article | 10/9/2021 |
| Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis. | Epithelial TLR4 Signaling Activates DUOX2 to Induce Microbiota-Driven Tumorigenesis.
Burgueño JF, Fritsch J, González EE, Landau KS, Santander AM, Fernández I, Hazime H, Davies JM, Santaolalla R, Phillips MC, Diaz S, Dheer R, Brito N, Pignac-Kobinger J, Fernández E, Conner GE, Abreu MT., Free PMC Article | 07/24/2021 |
| All these results reveal a critical role of Duox2 in the infection-induced H2O2 production and the H2O2-mediated immune response to infection in the respiratory tract. | Chemiluminescence imaging of Duox2-derived hydrogen peroxide for longitudinal visualization of biological response to viral infection in nasal mucosa.
Kim HJ, Seo YH, An S, Jo A, Kwon IC, Kim S., Free PMC Article | 02/23/2019 |
| The findings illustrate for the first time that the extreme C-terminus of Duox2 is required for the functional activity of the enzyme . | CRISPR/Cas9-mediated modification of the extreme C-terminus impairs PDGF-stimulated activity of Duox2.
Tyurin-Kuzmin PA, Karagyaur MN, Rubtsov YP, Dyikanov DT, Vasiliev PA, Vorotnikov AV. | 12/22/2018 |
| Duox2 is necessary for the regulation of IFN secretion in in vivo lung, and pulmonary administration of Duox2 DNA using cationic polymer triggers the induction of type I and III IFNs resulting in more complete suppression of influenza A virus infection. | Intranasal delivery of Duox2 DNA using cationic polymer can prevent acute influenza A viral infection in vivo lung.
Kim BJ, Cho SW, Jeon YJ, An S, Jo A, Lim JH, Kim DY, Won TB, Han DH, Rhee CS, Kim HJ. | 10/27/2018 |
| Both Nox1 and Duox2 induce exfoliation of crypt epithelium, but only Nox1 induces apoptosis. NOX1 and DUOX2 may be potential therapeutic targets for treating ileocolitis in human patients suffering inflammatory bowel disease (IBD). | Deficiency in Duox2 activity alleviates ileitis in GPx1- and GPx2-knockout mice without affecting apoptosis incidence in the crypt epithelium.
Chu FF, Esworthy RS, Doroshow JH, Grasberger H, Donko A, Leto TL, Gao Q, Shen B., Free PMC Article | 12/2/2017 |
| dual oxidase-2 and IL-6 play important roles in GPR43-mediated skin inflammation. | GPR43 activation enhances psoriasis-like inflammation through epidermal upregulation of IL-6 and dual oxidase 2 signaling in a murine model.
Nadeem A, Ahmad SF, Al-Harbi NO, El-Sherbeeny AM, Al-Harbi MM, Almukhlafi TS. | 12/2/2017 |
| We propose that Duox2 is responsible for IFN-independent signaling for induction of pattern recognition receptors transcription and can control acute Influenza virus A infection at the beginning of infection. | Duox2 is required for the transcription of pattern recognition receptors in acute viral lung infection: An interferon-independent regulatory mechanism.
Hong SN, Kim JY, Kim H, Kim DY, Won TB, Han DH, Rhee CS, Kim HJ. | 11/18/2017 |
| DUOX2 regulates interactions between the intestinal microbiota and the mucosa to maintain immune homeostasis in mice. | Increased Expression of DUOX2 Is an Epithelial Response to Mucosal Dysbiosis Required for Immune Homeostasis in Mouse Intestine.
Grasberger H, Gao J, Nagao-Kitamoto H, Kitamoto S, Zhang M, Kamada N, Eaton KA, El-Zaatari M, Shreiner AB, Merchant JL, Owyang C, Kao JY., Free PMC Article | 04/2/2016 |
| these data indicate that the gut microbiota uses two distinct signaling pathways to induce Duox2 expression in the ileum and colon epithelium. | The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium.
Sommer F, Bäckhed F. | 10/31/2015 |
| Data suggest that proteinase-activated receptor 2 activation leads to up-regulation of the dual oxidase-2/reactive oxygen species pathway in airway epithelial cells (AECs). | Proteinase activated receptor-2-mediated dual oxidase-2 up-regulation is involved in enhanced airway reactivity and inflammation in a mouse model of allergic asthma.
Nadeem A, Alharbi NO, Vliagoftis H, Tyagi M, Ahmad SF, Sayed-Ahmed MM., Free PMC Article | 08/29/2015 |
| DUOX2-generated ROS induce AEC death. | Dual oxidase 2 in lung epithelia is essential for hyperoxia-induced acute lung injury in mice.
Kim MJ, Ryu JC, Kwon Y, Lee S, Bae YS, Yoon JH, Ryu JH., Free PMC Article | 06/27/2015 |
| a spontaneously generated valine 674-to-glycine mutation of murine Duox2 results in a translocation defect and complete loss of function that explains the severe congenital hypothyroid phenotype of the thyd/thyd mouse strain | Hypothyroidism-associated missense mutation impairs NADPH oxidase activity and intracellular trafficking of Duox2.
Donkó Á, Morand S, Korzeniowska A, Boudreau HE, Zana M, Hunyady L, Geiszt M, Leto TL., Free PMC Article | 05/16/2015 |
| DUOX2 plays pivotal roles in TLR5-dependent inflammatory response of nasal airway epithelium. | Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.
Joo JH, Ryu JH, Kim CH, Kim HJ, Suh MS, Kim JO, Chung SY, Lee SN, Kim HM, Bae YS, Yoon JH. | 03/10/2012 |
| DUOX2 and NOD2 cooperatively facilitate antibacterial action. | DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.
Lipinski S, Till A, Sina C, Arlt A, Grasberger H, Schreiber S, Rosenstiel P. | 01/21/2010 |
| The cochleae of mutant mice exhibit abnormalities characteristic of hypothyroidism, including a delayed formation of the inner sulcus and tunnel of Corti and an abnormally thickened tectorial membrane. | Congenital hypothyroidism, dwarfism, and hearing impairment caused by a missense mutation in the mouse dual oxidase 2 gene, Duox2.
Johnson KR, Marden CC, Ward-Bailey P, Gagnon LH, Bronson RT, Donahue LR. | 01/21/2010 |