| Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis. | Apoptotic metabolites ameliorate bone aging phenotypes via TCOF1/FLVCR1-mediated mitochondrial homeostasis.
Qu Y, Meng B, Cai S, Yang B, He Y, Fu C, Li X, Li P, Cao Z, Mao X, Teng W, Shi S., Free PMC Article | 09/13/2024 |
| Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice. | Tcof1 haploinsufficiency promotes early T cell precursor-like leukemia in Nras(Q61R/+) mice.
Wen Z, Finn R, Gao X, Li L, Hebert A, Ranheim EA, Zhou Y, Yun G, Roose JP, Coon JJ, Shiang R, Wen R, Yu M, Wang D, Zhang J., Free PMC Article | 07/9/2022 |
| Role of Tcof1 in normal embryonic development, the correlation between genetic and environmental factors on the severity of craniofacial abnormalities, and the prospect for prenatal prevention of craniofacial anomalies. [review] | Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.
Sakai D, Trainor PA., Free PMC Article | 02/4/2017 |
| Tcof1 acts as a modifier of Pax3 during enteric nervous system development. | Tcof1 acts as a modifier of Pax3 during enteric nervous system development and in the pathogenesis of colonic aganglionosis.
Barlow AJ, Dixon J, Dixon M, Trainor PA., Free PMC Article | 08/31/2013 |
| identified Tcof1 as an important regulator of vagal neural crest cells (NCC) development and enteric nervous system formation; Tcof1 loss-of-function results in a deficiency of vagal NCC and their delayed colonization of the gut during early embryogenesis, which mimics the early stages of Hirschsprung's disease | Balancing neural crest cell intrinsic processes with those of the microenvironment in Tcof1 haploinsufficient mice enables complete enteric nervous system formation.
Barlow AJ, Dixon J, Dixon MJ, Trainor PA., Free PMC Article | 11/24/2012 |
| our research has therefore identified Treacle and as novel in vivo regulators of spindle fidelity, mitotic progression, and proliferation in the maintenance and localization of neural progenitor cells. | Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells.
Sakai D, Dixon J, Dixon MJ, Trainor PA., Free PMC Article | 09/8/2012 |
| Loss-of-function mutation in Tcof1 results in defects in middle ear postnatal development and conductive hearing loss. | Defects in middle ear cavitation cause conductive hearing loss in the Tcof1 mutant mouse.
Richter CA, Amin S, Linden J, Dixon J, Dixon MJ, Tucker AS. | 09/20/2010 |
| It has been hypothesized that mutations in Tcof1 disrupt ribosome biogenesis to a degree that is insufficient to meet the proliferative needs of the neuroepithelium and neural crest cells. | Treacher Collins syndrome: unmasking the role of Tcof1/treacle.
Sakai D, Trainor PA., Free PMC Article | 01/21/2010 |
| A minimal promoter fragment from -253 to +43 bp directs constitutive expression in both cell types, and dual regulation of Tcof1 appears to be through differential repression of this minimal promoter. | Regulation of the mouse Treacher Collins syndrome homolog (Tcof1) promoter through differential repression of constitutive expression.
Shows KH, Shiang R., Free PMC Article | 01/21/2010 |
| Analysis of RNA isolated from wild-type and Tcof1+/- heterozygous mice embryos from strains that exhibit a lethal phenotype showed significant reduction in 2'-O-methylation at nucleotide C463 of 18S rRNA | The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNA methylation.
Gonzales B, Henning D, So RB, Dixon J, Dixon MJ, Valdez BC. | 01/21/2010 |
| Data show that Tcof1 and treacle synthesis play an important role in the proliferation of neuroblastoma cells. | Genomewide analysis of gene expression associated with Tcof1 in mouse neuroblastoma.
Mogass M, York TP, Li L, Rujirabanjerd S, Shiang R. | 01/21/2010 |
| Results show that treacle is involved in ribosomal DNA gene transcription by interacting with upstream binding factor (UBF). | The Treacher Collins syndrome (TCOF1) gene product is involved in ribosomal DNA gene transcription by interacting with upstream binding factor.
Valdez BC, Henning D, So RB, Dixon J, Dixon MJ., Free PMC Article | 01/21/2010 |