| Tbl1 promotes Wnt-beta-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells. | Tbl1 promotes Wnt-β-catenin signaling-induced degradation of the Tcf7l1 protein in mouse embryonic stem cells.
Yu Y, Liu L, Cao J, Huang R, Duan Q, Ye SD. | 07/15/2024 |
| TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine. | TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small Intestine.
Zinina VV, Sauer M, Nigmatullina L, Kreim N, Soshnikova N., Free PMC Article | 06/14/2023 |
| The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency. | The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency.
Athanasouli P, Balli M, De Jaime-Soguero A, Boel A, Papanikolaou S, van der Veer BK, Janiszewski A, Vanhessche T, Francis A, El Laithy Y, Nigro AL, Aulicino F, Koh KP, Pasque V, Cosma MP, Verfaillie C, Zwijsen A, Heindryckx B, Nikolaou C, Lluis F., Free PMC Article | 03/8/2023 |
| TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state. | TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state.
Doumpas N, Söderholm S, Narula S, Moreira S, Doble BW, Cantù C, Basler K. | 02/19/2022 |
| A beta-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells. | A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells.
Guo Q, Kim A, Li B, Ransick A, Bugacov H, Chen X, Lindström N, Brown A, Oxburgh L, Ren B, McMahon AP., Free PMC Article | 02/5/2022 |
| beta-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells. | β-catenin stimulates Tcf7l1 degradation through recruitment of casein kinase 2 in mouse embryonic stem cells.
Zhang Y, Zhu Z, Ding H, Wan S, Zhang X, Li Y, Ji J, Wang X, Zhang M, Ye SD. | 10/24/2020 |
| Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells. | Tcf7l1 directly regulates cardiomyocyte differentiation in embryonic stem cells.
Liang R, Liu Y., Free PMC Article | 03/16/2019 |
| Telomeric noncoding RNA maintains the pluripotency of murine embryonic stem cells serving as a responding mediator to the Wnt/beta-catenin signaling changes, eventually modulating the expression of TCF3, a well-established primary repressor for mESC stemness. | Telomeric noncoding RNA promotes mouse embryonic stem cell self-renewal through inhibition of TCF3 activity.
Xu X, Guo M, Zhang N, Ye S. | 03/13/2019 |
| Tcf7l1 defines the border between the neural crest and the prospective forebrain via restriction of the Wnt/beta-catenin signaling gradient. | Tcf7l1 protects the anterior neural fold from adopting the neural crest fate.
Mašek J, Machoň O, Kořínek V, Taketo MM, Kozmik Z. | 09/9/2017 |
| report the identification of two independent missense variants in human TCF7L1, p.R92P and p.R400Q, in a cohort of patients with forebrain and/or pituitary defects | Transcription factor 7-like 1 is involved in hypothalamo-pituitary axis development in mice and humans.
Gaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S, Gualtieri A, Basu B, Koniordou M, Wu CI, Bancalari RE, Rahikkala E, Veijola R, Lopponen T, Graziola F, Turton J, Signore M, Mousavy Gharavy SN, Charolidi N, Sokol SY, Andoniadou CL, Wilson SW, Merrill BJ, Dattani MT, Martinez-Barbera JP., Free PMC Article | 08/20/2016 |
| The authors find that downstream of glycogen synthase kinase 3 inhibition, elevated cMyc and beta-catenin act in parallel to reduce transcription and DNA binding, respectively, of the transcriptional repressor Tcf7l1. | Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.
Morrison G, Scognamiglio R, Trumpp A, Smith A., Free PMC Article | 06/28/2016 |
| Sox4 and Tcf7l1 form a functional axis that promotes the progression of BCR-ABL-positive acute lymphoblastic leukemia. | The Sox4/Tcf7l1 axis promotes progression of BCR-ABL-positive acute lymphoblastic leukemia.
Ma H, Mallampati S, Lu Y, Sun B, Wang E, Leng X, Gong Y, Shen H, Yin CC, Jones D, Amin HM, You MJ, Zweidler-McKay P, Ma Y, Kantarjian HM, Arlinghaus RB, Glassman A, Sun X., Free PMC Article | 04/18/2015 |
| The role of Tcf7l1 in mammals is to inhibit the gene regulatory network to ensure the coordination of lineage specification with the dynamic cellular events occurring during gastrulation. | Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification.
Hoffman JA, Wu CI, Merrill BJ., Free PMC Article | 06/8/2013 |
| results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency | Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells.
Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS, Steger DJ, Lazar MA., Free PMC Article | 11/26/2011 |
| Studies present the precise distribution of gene expression of canonical Wnt pathway transcriptional regulators, Tcf1, Lef1, Tcf3, Tcf4 and beta-catenin between | Gene expression analysis of canonical Wnt pathway transcriptional regulators during early morphogenesis of the facial region in the mouse embryo.
Vendrell V, Summerhurst K, Sharpe J, Davidson D, Murphy P. | 01/21/2010 |
| Tcf3 is a cell-intrinsic inhibitor of pluripotent cell self-renewal that functions by limiting steady-state levels of self-renewal factors | Tcf3 functions as a steady-state limiter of transcriptional programs of mouse embryonic stem cell self-renewal.
Yi F, Pereira L, Merrill BJ., Free PMC Article | 01/21/2010 |
| Tcf3 has an important role in modulating the appropriate level of gene transcription in embryonic stem cells and during embryonic development | T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways.
Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B, Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B., Free PMC Articles: PMC2692055, PMC2692055 | 01/21/2010 |
| Tcf3 binds to and represses the Oct4 promoter, and this repressive effect requires both the Groucho and CtBP interacting domains of Tcf3. Tcf3 expression is coregulated with Oct4 and Nanog. | T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways.
Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B, Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B., Free PMC Articles: PMC2692055, PMC2692055 | 09/29/2008 |
| Critical steps in the recovery of the adult thymus include expansion of thymic epithelial cell progenitors and elevated expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma. | Regeneration of the adult thymus is preceded by the expansion of K5+K8+ epithelial cell progenitors and by increased expression of Trp63, cMyc and Tcf3 transcription factors in the thymic stroma.
Popa I, Zubkova I, Medvedovic M, Romantseva T, Mostowski H, Boyd R, Zaitseva M. | 01/21/2010 |
| Suggest role for Tcf3 in Wnt signaling mediated fetal intestinal villus morphogenesis. | Phases of canonical Wnt signaling during the development of mouse intestinal epithelium.
Kim BM, Mao J, Taketo MM, Shivdasani RA. | 01/21/2010 |
| Tcf3-/- embryos proceed through gastrulation to form mesoderm, but they develop expanded and often duplicated axial mesoderm structures, including nodes and notochords. | Tcf3: a transcriptional regulator of axis induction in the early embryo.
Merrill BJ, Pasolli HA, Polak L, Rendl M, García-García MJ, Anderson KV, Fuchs E. | 01/21/2010 |
| These data suggest that in the absence of Wnt signals, Tcf3 may function in skin SCs to maintain an undifferentiated state and, through Wnt signaling, directs these cells along the hair lineage. | Tcf3 governs stem cell features and represses cell fate determination in skin.
Nguyen H, Rendl M, Fuchs E. | 01/21/2010 |
| Tcf3-mediated control of Nanog levels allows stem cells to balance the creation of lineage-committed and undifferentiated cells | Repression of Nanog gene transcription by Tcf3 limits embryonic stem cell self-renewal.
Pereira L, Yi F, Merrill BJ., Free PMC Article | 01/21/2010 |
| E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells | E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells.
Bayly R, Chuen L, Currie RA, Hyndman BD, Casselman R, Blobel GA, LeBrun DP. | 01/21/2010 |