| The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function. | The nephric mesenchyme lineage of intermediate mesoderm is derived from Tbx6-expressing derivatives of neuro-mesodermal progenitors via BMP-dependent Osr1 function.
Hayashi S, Suzuki H, Takemoto T. | 10/16/2021 |
| Functionally distinct roles for T and Tbx6 during mouse development. | Functionally distinct roles for T and Tbx6 during mouse development.
Wehn AK, Farkas DR, Sedlock CE, Subedi D, Chapman DL., Free PMC Article | 09/18/2021 |
| Increased TBX6 gene dosages induce congenital cervical vertebral malformations in humans and mice. | Increased TBX6 gene dosages induce congenital cervical vertebral malformations in humans and mice.
Ren X, Yang N, Wu N, Xu X, Chen W, Zhang L, Li Y, Du RQ, Dong S, Zhao S, Chen S, Jiang LP, Wang L, Zhang J, Wu Z, Jin L, Qiu G, Lupski JR, Shi J, Zhang F, Liu P., Free PMC Article | 06/12/2021 |
| Tbx6 promotes cardiomyocyte proliferation in postnatal and adult mouse hearts by modifying the expression of cell cycle regulators. | Tbx6 induces cardiomyocyte proliferation in postnatal and adult mouse hearts.
Haginiwa S, Sadahiro T, Kojima H, Isomi M, Tamura F, Kurotsu S, Tani H, Muraoka N, Miyake N, Miyake K, Fukuda K, Ieda M. | 07/11/2020 |
| The prolonged Tbx6 expression suppressed cardiac differentiation and induced somite lineages, including skeletal muscle and chondrocytes. Thus, Tbx6 is critical for mesoderm induction and subsequent lineage diversification. | Tbx6 Induces Nascent Mesoderm from Pluripotent Stem Cells and Temporally Controls Cardiac versus Somite Lineage Diversification.
Sadahiro T, Isomi M, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tamura F, Tani H, Tohyama S, Fujita J, Miyoshi H, Kawamura Y, Goshima N, Iwasaki YW, Murano K, Saito K, Oda M, Andersen P, Kwon C, Uosaki H, Nishizono H, Fukuda K, Ieda M., Free PMC Article | 10/5/2019 |
| our findings in the newly collected human Congenital vertebral malformations (CVMs) subjects and Tbx6 mouse models consistently support the contention that TBX6 compound inheritance causes CVMs, potentially via a gene dosage-dependent mechanism. | TBX6 compound inheritance leads to congenital vertebral malformations in humans and mice.
Yang N, Wu N, Zhang L, Zhao Y, Liu J, Liang X, Ren X, Li W, Chen W, Dong S, Zhao S, Lin J, Xiang H, Xue H, Chen L, Sun H, Zhang J, Shi J, Zhang S, Lu D, Wu X, Jin L, Ding J, Qiu G, Wu Z, Lupski JR, Zhang F., Free PMC Article | 06/22/2019 |
| In Tbx6 null mutant embryos intermediate mesoderm formation is severely compromised. | Impaired intermediate formation in mouse embryos expressing reduced levels of Tbx6.
Chapman DL., Free PMC Article | 05/11/2019 |
| The authors succeeded in reproducing in vivo events using a mouse embryonic stem cell induction system, in which Tbx6 degradation occurred via Ripply2. | Ripply2 recruits proteasome complex for Tbx6 degradation to define segment border during murine somitogenesis.
Zhao W, Oginuma M, Ajima R, Kiso M, Okubo A, Saga Y., Free PMC Article | 05/4/2019 |
| Hes7 expression in the presomitic mesoderm was up-regulated through the E-box, T-box, and RBPj-binding element in the Hes7 essential region, presumably through synergistic signaling involving mesogenin1, T-box6 (Tbx6), and Notch1. | Presomitic mesoderm-specific expression of the transcriptional repressor Hes7 is controlled by E-box, T-box, and Notch signaling pathways.
Hayashi S, Nakahata Y, Kohno K, Matsui T, Bessho Y., Free PMC Article | 02/23/2019 |
| This study emphasizes the function of Tbx6 as a bistable switch that turns mesoderm fate 'on' and progenitor state 'off', and thus has implications for the molecular mechanism driving neuromesoderm progenitors fate choice. | Co-expression of Tbx6 and Sox2 identifies a novel transient neuromesoderm progenitor cell state.
Javali A, Misra A, Leonavicius K, Acharyya D, Vyas B, Sambasivan R. | 01/6/2018 |
| Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2. | Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2.
Zhao W, Ajima R, Ninomiya Y, Saga Y. | 05/23/2015 |
| Tbx6 and the Wnt pathway cooperatively regulate proper Hes7 expression. | Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock.
González A, Manosalva I, Liu T, Kageyama R., Free PMC Article | 07/6/2013 |
| Tbx6 is required for cardiac myocyte differentiation and represses neural differentiation in the P19CL6 model. | Tbx6 is a determinant of cardiac and neural cell fate decisions in multipotent P19CL6 cells.
Gavrilov S, Nührenberg TG, Ashton AW, Peng CF, Moore JC, Konstantinidis K, Mummery CL, Kitsis RN., Free PMC Article | 11/17/2012 |
| Tbx6 acts in the mesoderm where it has a dual function. It promotes differentiation of cells into paraxial mesoderm, and it suppresses neural cell fate specification by repressing Sox2. | Interaction of Wnt3a, Msgn1 and Tbx6 in neural versus paraxial mesoderm lineage commitment and paraxial mesoderm differentiation in the mouse embryo.
Nowotschin S, Ferrer-Vaquer A, Concepcion D, Papaioannou VE, Hadjantonakis AK., Free PMC Article | 08/4/2012 |
| Tbx6 represses Sox2 by inactivating enhancer N1 to inhibit neural development, and this is an essential step for the specification of paraxial mesoderm from the axial stem cells. | Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells.
Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE, Kondoh H., Free PMC Article | 03/5/2011 |
| determined the phenotypic and molecular consequences of ectopically expressing Tbx6 within the segmented paraxial mesoderm and its derivatives using a 3-component transgenic system | Tbx18 and Tbx15 null-like phenotypes in mouse embryos expressing Tbx6 in somitic and lateral plate mesoderm.
Wehn AK, Chapman DL. | 11/6/2010 |
| Smad6 facilitates the degradation of Tbx6 protein through recruitment of Smurf1. | Smad6 inhibits the transcriptional activity of Tbx6 by mediating its degradation.
Chen YL, Liu B, Zhou ZN, Hu RY, Fei C, Xie ZH, Ding X., Free PMC Article | 01/21/2010 |
| An Mesp2 enhancer knockout mouse bearing mutations in two crucial Tbx6 binding sites does not express Mesp2 in the presomitic mesoderm. | Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2.
Yasuhiko Y, Kitajima S, Takahashi Y, Oginuma M, Kagiwada H, Kanno J, Saga Y. | 01/21/2010 |
| Mesp2 protein leads to the suppression of Tbx6 protein expression post-translationally via rapid degradation mediated by the ubiquitin-proteasome pathway | Mesp2 and Tbx6 cooperatively create periodic patterns coupled with the clock machinery during mouse somitogenesis.
Oginuma M, Niwa Y, Chapman DL, Saga Y. | 01/21/2010 |
| conclude that the transcription factor gene Tbx6 is essential for correct left/right axis determination in the mouse and acts through effects on notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia | Tbx6 regulates left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling.
Hadjantonakis AK, Pisano E, Papaioannou VE., Free PMC Article | 01/21/2010 |
| The expression of mesogenin 1, a basic helix-loop-helix transcription factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism. | Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6.
Wittler L, Shin EH, Grote P, Kispert A, Beckers A, Gossler A, Werber M, Herrmann BG., Free PMC Article | 01/21/2010 |
| Tbx18 interacts with Gata4 and Nkx2-5 and competes Tbx5-mediated activation of the cardiac Natriuretic peptide precursor type a-promoter. Tbx18 down-regulates Tbx6-activated Delta-like 1 expression in the somitic mesoderm in vivo | Transcriptional repression by the T-box proteins Tbx18 and Tbx15 depends on Groucho corepressors.
Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A. | 01/21/2010 |
| Contol of Tbx6 gene expression during development. | Regulation of Tbx6 expression by Notch signaling.
White PH, Farkas DR, Chapman DL. | 01/21/2010 |
| uncovered four putative Tbx6 binding sites within a delta-like 1 paraxial mesoderm enhancer | Dll1 is a downstream target of Tbx6 in the paraxial mesoderm.
White PH, Chapman DL. | 01/21/2010 |
| a role in paraxial mesoderm formation | The mouse rib-vertebrae mutation is a hypomorphic Tbx6 allele.
Watabe-Rudolph M, Schlautmann N, Papaioannou VE, Gossler A. | 01/21/2010 |