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    Syt1 synaptotagmin I [ Mus musculus (house mouse) ]

    Gene ID: 20979, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter release.

    A de novo missense mutation in synaptotagmin-1 associated with neurodevelopmental disorder desynchronizes neurotransmitter release.
    van Boven MA, Mestroni M, Zwijnenburg PJG, Verhage M, Cornelisse LN., Free PMC Article

    10/11/2024
    STON2 variations are involved in synaptic dysfunction and schizophrenia-like behaviors by regulating Syt1 trafficking.

    STON2 variations are involved in synaptic dysfunction and schizophrenia-like behaviors by regulating Syt1 trafficking.
    Ma Y, Gao K, Sun X, Wang J, Yang Y, Wu J, Chai A, Yao L, Liu N, Yu H, Su Y, Lu T, Wang L, Yue W, Zhang X, Xu L, Zhang D, Li J.

    05/30/2024
    Calcium ions promote migrasome formation via Synaptotagmin-1.

    Calcium ions promote migrasome formation via Synaptotagmin-1.
    Han Y, Yu L., Free PMC Article

    05/6/2024
    Enriched Environment Enhances Sociability Through the Promotion of ESyt1-Related Synaptic Formation in the Medial Prefrontal Cortex.

    Enriched Environment Enhances Sociability Through the Promotion of ESyt1-Related Synaptic Formation in the Medial Prefrontal Cortex.
    Zhang M, Li X, Zhuo S, Yang M, Yu Z.

    04/26/2024
    Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis.

    Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis.
    Bolz S, Kaempf N, Puchkov D, Krauss M, Russo G, Soykan T, Schmied C, Lehmann M, Müller R, Schultz C, Perrais D, Maritzen T, Haucke V.

    12/21/2023
    Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.

    Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1.
    Ma Y, Zhao R, Guo H, Tong Q, Langdon WY, Liu W, Zhang J, Zhang J., Free PMC Article

    08/3/2023
    Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.

    Synaptotagmin-1-dependent phasic axonal dopamine release is dispensable for basic motor behaviors in mice.
    Delignat-Lavaud B, Kano J, Ducrot C, Massé I, Mukherjee S, Giguère N, Moquin L, Lévesque C, Burke S, Denis R, Bourque MJ, Tchung A, Rosa-Neto P, Lévesque D, De Beaumont L, Trudeau LÉ., Free PMC Article

    07/13/2023
    Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.

    Rab26 restricts insulin secretion via sequestering Synaptotagmin-1.
    Zhuang R, Zhou Y, Wang Z, Cao Y, Chen J, Xu L, Ren Y, Zheng Y, Wei Z, Qiu H, Li L, Han Y, Yun Y, Chen X, Hong W, Wang T., Free PMC Article

    06/26/2023
    Synaptotagmin-1 is a Ca[2+] sensor for somatodendritic dopamine release.

    Synaptotagmin-1 is a Ca(2+) sensor for somatodendritic dopamine release.
    Lebowitz JJ, Banerjee A, Qiao C, Bunzow JR, Williams JT, Kaeser PS., Free PMC Article

    02/11/2023
    Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release.

    Polybasic Patches in Both C2 Domains of Synaptotagmin-1 Are Required for Evoked Neurotransmitter Release.
    Wu Z, Ma L, Courtney NA, Zhu J, Landajuela A, Zhang Y, Chapman ER, Karatekin E., Free PMC Article

    08/6/2022
    Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.

    Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release.
    Hikima T, Witkovsky P, Khatri L, Chao MV, Rice ME., Free PMC Article

    05/21/2022
    Synaptotagmin-1 is a bidirectional Ca(2+) sensor for neuronal endocytosis.

    Synaptotagmin-1 is a bidirectional Ca(2+) sensor for neuronal endocytosis.
    Chen Y, Hu S, Wu X, Xie Z, Wang Y, Wang B, Li X, Pei Y, Gu Y, Huang K, Huo J, Wei A, Bi C, Lu Z, Song Q, Xu H, Kang X, Shao S, Long J, Liu J, Zhou Z, Huang R, Chai Z, Wang C., Free PMC Article

    05/14/2022
    Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release.

    Deconstructing Synaptotagmin-1's Distinct Roles in Synaptic Vesicle Priming and Neurotransmitter Release.
    Bouazza-Arostegui B, Camacho M, Brockmann MM, Zobel S, Rosenmund C., Free PMC Article

    04/16/2022
    miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons.

    miR-128 as a Regulator of Synaptic Properties in 5xFAD Mice Hippocampal Neurons.
    Shvarts-Serebro I, Sheinin A, Gottfried I, Adler L, Schottlender N, Ashery U, Barak B.

    03/5/2022
    Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons.

    Synaptotagmin-1 interacts with PI(4,5)P2 to initiate synaptic vesicle docking in hippocampal neurons.
    Chen Y, Wang YH, Zheng Y, Li M, Wang B, Wang QW, Fu CL, Liu YN, Li X, Yao J.

    01/29/2022
    Neuromodulator release in neurons requires two functionally redundant calcium sensors.

    Neuromodulator release in neurons requires two functionally redundant calcium sensors.
    van Westen R, Poppinga J, Díez Arazola R, Toonen RF, Verhage M., Free PMC Article

    12/4/2021
    Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons.

    Ca(2+) sensor proteins in spontaneous release and synaptic plasticity: Limited contribution of Doc2c, rabphilin-3a and synaptotagmin 7 in hippocampal glutamatergic neurons.
    Bourgeois-Jaarsma Q, Miaja Hernandez P, Groffen AJ.

    11/27/2021
    Synaptotagmin 1 regulates cortical granule exocytosis during mouse oocyte activation.

    Synaptotagmin 1 regulates cortical granule exocytosis during mouse oocyte activation.
    Zhu XL, Li SF, Zhang XQ, Xu H, Luo YQ, Yi YH, Lv LJ, Zhang CH, Wang ZB, Ouyang YC, Hou Y, Schatten H, Liu FH.

    10/23/2021
    miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus.

    miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus.
    Wang P, Zhang Y, Wang Z, Yang A, Li Y, Zhang Q.

    05/15/2021
    Synaptotagmin-1 is the Ca(2+) sensor for fast striatal dopamine release.

    Synaptotagmin-1 is the Ca(2+) sensor for fast striatal dopamine release.
    Banerjee A, Lee J, Nemcova P, Liu C, Kaeser PS., Free PMC Article

    03/20/2021
    Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1.

    Post-tetanic potentiation lowers the energy barrier for synaptic vesicle fusion independently of Synaptotagmin-1.
    Huson V, Meijer M, Dekker R, Ter Veer M, Ruiter M, van Weering JR, Verhage M, Cornelisse LN., Free PMC Article

    03/13/2021
    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.

    Acute disruption of the synaptic vesicle membrane protein synaptotagmin 1 using knockoff in mouse hippocampal neurons.
    Vevea JD, Chapman ER., Free PMC Article

    02/27/2021
    Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.

    Hepatic Synaptotagmin 1 is involved in the remodelling of liver plasma- membrane lipid composition and gene expression in male Apoe-deficient mice consuming a Western diet.
    Sancho-Knapik S, Pastor O, Barranquero C, Herrera Marcos LV, Guillén N, Arnal C, Gascón S, Navarro MA, Rodríguez-Yoldi MJ, Busto R, Lasunción MA, Osada J.

    01/9/2021
    An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking.

    An Epilepsy-Associated SV2A Mutation Disrupts Synaptotagmin-1 Expression and Activity-Dependent Trafficking.
    Harper CB, Small C, Davenport EC, Low DW, Smillie KJ, Martínez-Mármol R, Meunier FA, Cousin MA., Free PMC Article

    10/24/2020
    Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner.

    Synaptotagmin-1 enables frequency coding by suppressing asynchronous release in a temperature dependent manner.
    Huson V, van Boven MA, Stuefer A, Verhage M, Cornelisse LN., Free PMC Article

    10/24/2020
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