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    Stat3 signal transducer and activator of transcription 3 [ Mus musculus (house mouse) ]

    Gene ID: 20848, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    MiR-144/451 attenuates lipopolysaccharide-induced lung inflammation by downregulating Rac1 and STAT-3 in macrophages.

    MiR-144/451 attenuates lipopolysaccharide-induced lung inflammation by downregulating Rac1 and STAT-3 in macrophages.
    He S, Gao X, Yang L, Li X, Mo Y, He Z, Hou R, Yuan X, Fang L, Yu D.

    11/5/2024
    The STAT3/SETDB2 axis dictates NF-kappaB-mediated inflammation in macrophages during wound repair.

    The STAT3/SETDB2 axis dictates NF-κB-mediated inflammation in macrophages during wound repair.
    Mangum KD, denDekker A, Li Q, Tsoi LC, Joshi AD, Melvin WJ, Wolf SJ, Moon JY, Audu CO, Shadiow J, Obi AT, Wasikowski R, Barrett EC, Bauer TM, Boyer K, Ahmed Z, Davis FM, Gudjonsson J, Gallagher KA., Free PMC Article

    10/30/2024
    Stat3-mediated Atg7 expression regulates anti-tumor immunity in mouse melanoma.

    Stat3-mediated Atg7 expression regulates anti-tumor immunity in mouse melanoma.
    Zimmerman SM, Suh E, Smith SR, Souroullas GP., Free PMC Article

    10/25/2024
    Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.

    Astrocytic DLL4-NOTCH1 signaling pathway promotes neuroinflammation via the IL-6-STAT3 axis.
    Mora P, Laisné M, Bourguignon C, Rouault P, Jaspard-Vinassa B, Maître M, Gadeau AP, Renault MA, Horng S, Couffinhal T, Chapouly C., Free PMC Article

    10/18/2024
    IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis.

    IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis.
    Zhang P, Liu J, Lee A, Tsaur I, Ohira M, Duong V, Vo N, Watari K, Su H, Kim JY, Gu L, Zhu M, Shalapour S, Hosseini M, Bandyopadhyay G, Zeng S, Llorente C, Zhao HN, Lamichhane S, Mohan S, Dorrestein PC, Olefsky JM, Schnabl B, Soroosh P, Karin M.

    10/16/2024
    STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation.

    STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation.
    Luo L, Wang F, Xu X, Ma M, Kuang G, Zhang Y, Wang D, Li W, Zhang N, Zhao K., Free PMC Article

    10/8/2024
    Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages.

    Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages.
    Feng Z, Meng F, Huo F, Zhu Y, Qin Y, Gui Y, Zhang H, Lin P, He Q, Li Y, Geng J, Wu J., Free PMC Article

    10/2/2024
    Brown adipose tissue-derived exosomes improve polycystic ovary syndrome in mice via STAT3/GPX4 signaling pathway.

    Brown adipose tissue-derived exosomes improve polycystic ovary syndrome in mice via STAT3/GPX4 signaling pathway.
    Fang YQ, Zhang HK, Wei QQ, Li YH.

    09/30/2024
    A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis.

    A hepatocyte-specific transcriptional program driven by Rela and Stat3 exacerbates experimental colitis in mice by modulating bile synthesis.
    Jyotsna, Sarkar B, Yadav M, Deka A, Markandey M, Sanyal P, Nagarajan P, Gaikward N, Ahuja V, Mohanty D, Basak S, Gokhale RS., Free PMC Article

    09/25/2024
    SPRR1B+ keratinocytes prime oral mucosa for rapid wound healing via STAT3 activation.

    SPRR1B+ keratinocytes prime oral mucosa for rapid wound healing via STAT3 activation.
    Xuanyuan X, Zhang L, Zheng Y, Jiang R, Ma Y, Liu R, Hou P, Lei M, Xu H, Zeng H., Free PMC Article

    09/25/2024
    RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice.

    RACK1 enhances STAT3 stability and promotes T follicular helper cell development and function during blood-stage Plasmodium infection in mice.
    Cheng Q, Yang X, Zou T, Sun L, Zhang X, Deng L, Wu M, Gai W, Jiang H, Guo T, Lu Y, Dong J, Niu C, Pan W, Zhang J., Free PMC Article

    09/9/2024
    Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus.

    Circulating extracellular vesicle-derived miR-1299 disrupts hepatic glucose homeostasis by targeting the STAT3/FAM3A axis in gestational diabetes mellitus.
    Chen X, Tao X, Wang M, Cannon RD, Chen B, Yu X, Qi H, Saffery R, Baker PN, Zhou X, Han TL, Zhang H., Free PMC Article

    08/30/2024
    HIPK2 mediates M1 polarization of microglial cells via STAT3: A new mechanism of depression-related neuroinflammation.

    HIPK2 mediates M1 polarization of microglial cells via STAT3: A new mechanism of depression-related neuroinflammation.
    Han C, Pei H, Sheng Y, Wang J, Zhou X, Li W, Zhang C, Guo L, Yang Y.

    08/1/2024
    Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis.

    Tumor-associated NK cells drive MDSC-mediated tumor immune tolerance through the IL-6/STAT3 axis.
    Neo SY, Tong L, Chong J, Liu Y, Jing X, Oliveira MMS, Chen Y, Chen Z, Lee K, Burduli N, Chen X, Gao J, Ma R, Lim JP, Huo J, Xu S, Alici E, Wickström SL, Haglund F, Hartman J, Wagner AK, Cao Y, Kiessling R, Lam KP, Westerberg LS, Lundqvist A.

    08/1/2024
    Absence of PD-L1 signaling hinders macrophage defense against Mycobacterium tuberculosis via upregulating STAT3/IL-6 pathway.

    Absence of PD-L1 signaling hinders macrophage defense against Mycobacterium tuberculosis via upregulating STAT3/IL-6 pathway.
    Qu P, Li X, Liu W, Zhou F, Xu X, Tang J, Sun M, Li J, Li H, Han Y, Hu C, Lei Y, Pan Q, Zhan L.

    07/31/2024
    Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation.

    Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation.
    Yoon JH, Bae E, Nagafuchi Y, Sudo K, Han JS, Park SH, Nakae S, Yamashita T, Ju JH, Matsumoto I, Sumida T, Miyazawa K, Kato M, Kuroda M, Lee IK, Fujio K, Mamura M., Free PMC Article

    07/26/2024
    Plasmodium yoelii Infection Enhances the Expansion of Myeloid-Derived Suppressor Cells via JAK/STAT3 Pathway.

    Plasmodium yoelii Infection Enhances the Expansion of Myeloid-Derived Suppressor Cells via JAK/STAT3 Pathway.
    Zhu Y, Zhou L, Mo L, Hong C, Pan L, Lin J, Qi Y, Tan S, Qian M, Hu T, Zhao Y, Qiu H, Lin P, Ma X, Yang Q.

    07/11/2024
    Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma.

    Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma.
    Wang K, Lu Q, Luo Y, Yu G, Wang Z, Lin J, Tan Z, Lao Y, Liu S, Yang H., Free PMC Article

    06/26/2024
    Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis.

    Decreased HMGCS1 inhibits proliferation and inflammatory response of keratinocytes and ameliorates imiquimod-induced psoriasis via the STAT3/IL-23 axis.
    Chen L, Huang D, Huang Z, Liu X, He M, Luo M, Tang Z, Tan G, Guo Q, Xiong H.

    06/18/2024
    STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells.

    STAT3 inhibition recovers regeneration of aged muscles by restoring autophagy in muscle stem cells.
    Catarinella G, Bracaglia A, Skafida E, Procopio P, Ruggieri V, Parisi C, De Bardi M, Borsellino G, Madaro L, Puri PL, Sacco A, Latella L., Free PMC Article

    06/14/2024
    STAT3 inhibition ameliorates renal interstitial inflammation in MRL/lpr mice with diffuse proliferative lupus nephritis.

    STAT3 inhibition ameliorates renal interstitial inflammation in MRL/lpr mice with diffuse proliferative lupus nephritis.
    Zhu J, Chen Y, Chen Y, Lv Y, Chen T., Free PMC Article

    06/5/2024
    BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling.

    BAG3 promotes proliferation and migration of arterial smooth muscle cells by regulating STAT3 phosphorylation in diabetic vascular remodeling.
    Huang X, Guo J, Ning A, Zhang N, Sun Y., Free PMC Article

    04/29/2024
    Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.

    Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.
    Wang X, Zhang S, Lv B, Chen H, Zhang W, Dong L, Bao L, Wang M, Wang Y, Mao W, Cui L, Pang Y, Wang F, Yan F, Zhang Z, Cui G., Free PMC Article

    04/29/2024
    Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.

    Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.
    Qiu Y, Pei D, Wang M, Wang Q, Duan W, Wang L, Liu K, Guo Y, Luo L, Guo Z, Guan F, Wang Z, Xing A, Liu Z, Ma Z, Jiang G, Yan D, Liu X, Zhang Z, Wang W., Free PMC Article

    04/29/2024
    The binding of PKCepsilon and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.

    The binding of PKCε and MEG2 to STAT3 regulates IL-6-mediated microglial hyperalgesia during inflammatory pain.
    Li X, Wang J, Liao C, Yang X, Zhao Z, Liu Y, Xue Q, Luo Y, Liu X, Liu Z.

    04/26/2024
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