| DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1. | DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1.
Hu Y, Ye S, Kong J, Zhou Q, Wang Z, Zhang Y, Yan H, Wang Y, Li T, Xie Y, Chen B, Zhao Y, Zhang T, Zheng X, Niu J, Hu B, Wang S, Chen Z, Zheng C., Free PMC Article | 11/4/2024 |
| DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair. | DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair.
Tang H, Lu YF, Zeng R, Liu C, Shu Y, Wu Y, Su J, Di L, Qian J, Zhang J, Tian Y, Lu X, Pei XH, Zhu Q, Zhu WG., | 08/26/2024 |
| The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases. | The disruptor of telomeric silencing 1-like (DOT1L) promotes peritoneal fibrosis through the upregulation and activation of protein tyrosine kinases.
Tao M, Shi Y, Chen H, Li J, Wang Y, Ma X, Du L, Wang Y, Yang X, Hu Y, Zhou X, Zhong Q, Yan D, Qiu A, Zhuang S, Liu N., Free PMC Article | 06/3/2024 |
| Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression. | Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression.
Izzo A, Akol I, Villarreal A, Lebel S, Garcia-Miralles M, Cheffer A, Bovio P, Heidrich S, Vogel T., Free PMC Article | 12/20/2023 |
| DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. | DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons.
Cheffer A, Garcia-Miralles M, Maier E, Akol I, Franz H, Srinivasan VSV, Vogel T., Free PMC Article | 10/11/2023 |
| Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells. | Dot1l cooperates with Npm1 to repress endogenous retrovirus MERVL in embryonic stem cells.
Zhao X, Li X, Sun H, Zhao X, Gao T, Shi P, Chen F, Liu L, Lu X., Free PMC Article | 09/26/2023 |
| DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres. | DOT1L bridges transcription and heterochromatin formation at mammalian pericentromeres.
Malla AB, Yu H, Farris D, Kadimi S, Lam TT, Cox AL, Smith ZD, Lesch BJ., Free PMC Article | 08/4/2023 |
| DOT1L regulates chromatin reorganization and gene expression during sperm differentiation. | DOT1L regulates chromatin reorganization and gene expression during sperm differentiation.
Blanco M, El Khattabi L, Gobé C, Crespo M, Coulée M, de la Iglesia A, Ialy-Radio C, Lapoujade C, Givelet M, Delessard M, Seller-Corona I, Yamaguchi K, Vernet N, Van Leeuwen F, Lermine A, Okada Y, Daveau R, Oliva R, Fouchet P, Ziyyat A, Pflieger D, Cocquet J., Free PMC Article | 06/15/2023 |
| The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis. | The DOT1L-MLLT10 complex regulates male fertility and promotes histone removal during spermiogenesis.
Lin H, Cossu IG, Leu NA, Deshpande AJ, Bernt KM, Luo M, Wang PJ., Free PMC Article | 05/20/2023 |
| DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement. | DOT1L promotes spermatid differentiation by regulating expression of genes required for histone-to-protamine replacement.
Malla AB, Rainsford SR, Smith ZD, Lesch BJ., Free PMC Article | 05/20/2023 |
| Single-cell transcriptomics defines Dot1L interacting partners and downstream target genes in the mouse molar dental pulp. | Single-cell transcriptomics defines Dot1L interacting partners and downstream target genes in the mouse molar dental pulp.
Guzzo R, Enkhmandakh B, Becker T, Joshi P, Robson P, Vijaykumar A, Mina M, Shin DG, Bayarsaihan D. | 03/28/2023 |
| DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability. | DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.
Willemsen L, Prange KHM, Neele AE, van Roomen CPAA, Gijbels M, Griffith GR, Toom MD, Beckers L, Siebeler R, Spann NJ, Chen HJ, Bosmans LA, Gorbatenko A, van Wouw S, Zelcer N, Jacobs H, van Leeuwen F, de Winther MPJ. | 12/3/2022 |
| The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-kappaB pathway. | The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway.
Farina FM, Serio S, Hall IF, Zani S, Cassanmagnago GA, Climent M, Civilini E, Condorelli G, Quintavalle M, Elia L. | 11/29/2022 |
| Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells. | Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells.
Lin H, Cheng K, Kubota H, Lan Y, Riedel SS, Kakiuchi K, Sasaki K, Bernt KM, Bartolomei MS, Luo M, Wang PJ, Lin H, Cheng K, Kubota H, Lan Y, Riedel SS, Kakiuchi K, Sasaki K, Bernt KM, Bartolomei MS, Luo M, Wang PJ., Free PMC Articles: PMC9296001, PMC9296001 | 07/23/2022 |
| Loss of Dot1l results in a failure in spermatogonial stem cell self-renewal and thus male sterility. Dot1l promotes expression of the fate-determining HoxC transcription factors in spermatogonial stem cells. | Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells.
Lin H, Cheng K, Kubota H, Lan Y, Riedel SS, Kakiuchi K, Sasaki K, Bernt KM, Bartolomei MS, Luo M, Wang PJ, Lin H, Cheng K, Kubota H, Lan Y, Riedel SS, Kakiuchi K, Sasaki K, Bernt KM, Bartolomei MS, Luo M, Wang PJ., Free PMC Articles: PMC9296001, PMC9296001 | 06/30/2022 |
| DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin. | DOT1L Methyltransferase Regulates Calcium Influx in Erythroid Progenitor Cells in Response to Erythropoietin.
Feng Y, Borosha S, Ratri A, Lee EB, Wang H, Fields TA, Kinsey WH, Vivian JL, Rumi MAK, Fields PE., Free PMC Article | 05/21/2022 |
| The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis. | The histone methyltransferase DOT1L is a new epigenetic regulator of pulmonary fibrosis.
Yang D, Xu P, Su H, Zhong W, Xu J, Su Z, Liu X., Free PMC Article | 04/16/2022 |
| DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome. | DOT1L inhibition enhances pluripotency beyond acquisition of epithelial identity and without immediate suppression of the somatic transcriptome.
Wille CK, Sridharan R., Free PMC Article | 03/26/2022 |
| Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis. | Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis.
De Roover A, Núñez AE, Cornelis FM, Cherifi C, Casas-Fraile L, Sermon A, Cailotto F, Lories RJ, Monteagudo S., Free PMC Article | 03/12/2022 |
| Histone methyltransferase DOT1L mediates the TGF-beta1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction. | Histone methyltransferase DOT1L mediates the TGF-β1/Smad3 signaling pathway through epigenetic modification of SYK in myocardial infarction.
Li F, Li L, Zhang J, Yang X, Liu Y. | 02/5/2022 |
| Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia. | Targeted disruption of the histone lysine 79 methyltransferase Dot1L in nephron progenitors causes congenital renal dysplasia.
Wang F, Ngo J, Li Y, Liu H, Chen CH, Saifudeen Z, Sequeira-Lopez MLS, El-Dahr SS., Free PMC Article | 01/15/2022 |
| Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress. | Dot1l Aggravates Keratitis Induced by Herpes Simplex Virus Type 1 in Mice via p38 MAPK-Mediated Oxidative Stress.
Wan S, Zhou Y, Huang Q, Yang Y., Free PMC Article | 09/11/2021 |
| DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation. | DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation.
Shuai L, Li BH, Jiang HW, Yang L, Li J, Li JY. | 09/4/2021 |
| Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression. | Differentiation and localization of interneurons in the developing spinal cord depends on DOT1L expression.
Gray de Cristoforis A, Ferrari F, Clotman F, Vogel T., Free PMC Article | 07/10/2021 |
| Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice. | Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice.
Sutter PA, Karki S, Crawley I, Singh V, Bernt KM, Rowe DW, Crocker SJ, Bayarsaihan D, Guzzo RM., Free PMC Article | 06/26/2021 |