The GHSR1a antagonist LEAP2 regulates islet hormone release in a sex-specific manner.
Hewawasam N, Sarkar D, Bolton O, Delishaj B, Almutairi M, King AJF, Dereli AS, Despontin C, Gilon P, Reeves S, Patterson M, Hauge-Evans AC.

Increased GHS-R1a expression in the hippocampus impairs memory encoding and contributes to AD-associated memory deficits.
Zhang M, Yang L, Jia J, Xu F, Gao S, Han F, Deng M, Wang J, Li V, Yu M, Sun Y, Yuan H, Zhou Y, Li N., Free PMC Article

GHS-R1a deficiency protects against lipopolysaccharide-induced spatial memory impairment in mice.
Liu J, Li N, Wei C, Han F, Deng M, Ma J, Zou X, Zhou Y, Yang R, Yuan H.

Growth Hormone Secretagogue Receptor (GHSR) Signaling in the Ventral Tegmental Area (VTA) Mediates Feeding Produced by Chronic Social Defeat Stress in Male Mice.
Smith A, Rodrigues T, Wallace C, Mezher K, MacAulay B, Prowse R, Hyland L, Abizaid A.

GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced Hyperphagia in Male Mice.
Cornejo MP, Fernandez G, Cabral A, Barrile F, Heredia F, García Romero G, Zubimendi Sampieri JP, Quelas JI, Cantel S, Fehrentz JA, Alonso A, Pla R, Ferran JL, Andreoli MF, De Francesco PN, Perelló M.

Neuronal ablation of GHSR mitigates diet-induced depression and memory impairment via AMPK-autophagy signaling-mediated inflammation.
Wang H, Shen Z, Wu CS, Ji P, Noh JY, Geoffroy CG, Kim S, Threadgill D, Li J, Zhou Y, Xiao X, Zheng H, Sun Y., Free PMC Article

Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation.
Kim DM, Lee JH, Pan Q, Han HW, Shen Z, Eshghjoo S, Wu CS, Yang W, Noh JY, Threadgill DW, Guo S, Wright G, Alaniz R, Sun Y., Free PMC Article

Elevated Ghrelin Promotes Hippocampal Ghrelin Receptor Defects in Humanized Amyloid-β Knockin Mice During Aging.
Tian J, Du E, Jia K, Wang T, Guo L, Zigman JM, Du H., Free PMC Article

Nutrient-Sensing Ghrelin Receptor in Macrophages Modulates Bisphenol A-Induced Intestinal Inflammation in Mice.
Ye X, Liu Z, Han HW, Noh JY, Shen Z, Kim DM, Wang H, Guo H, Ballard J, Golovko A, Morpurgo B, Sun Y., Free PMC Article

GHSR1a deficiency suppresses inhibitory drive on dCA1 pyramidal neurons and contributes to memory reinforcement.
Li N, Li N, Yang L, Gu H, Ji J, Zhou H, Zhu Q, Yu M, Sun Y, Zhou Y.

Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity.
Conde K, Kulyk D, Vanschaik A, Daisey S, Rojas C, Wiersielis K, Yasrebi A, Degroat TJ, Sun Y, Roepke TA., Free PMC Article

Ablation of Ghrelin Receptor Mitigates the Metabolic Decline of Aging Skeletal Muscle.
O'Reilly C, Lin L, Wang H, Fluckey J, Sun Y., Free PMC Article

Growth hormone secretagogue receptor signaling in the supramammillary nucleus targets nitric oxide-producing neurons and controls recognition memory in mice.
Aguggia JP, Cornejo MP, Fernandez G, De Francesco PN, Mani BK, Cassano D, Cabral A, Valdivia S, García Romero G, Reynaldo M, Fehrentz JA, Zigman JM, Perello M.

GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Fernandez G, Cabral A, De Francesco PN, Uriarte M, Reynaldo M, Castrogiovanni D, Zubiría G, Giovambattista A, Cantel S, Denoyelle S, Fehrentz JA, Tolle V, Schiöth HB, Perello M., Free PMC Article

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets.
Pradhan G, Lee JH, Wu CS, Wang H, Lin L, Donti T, Graham BH, Rajan AS, Balasubramanyam A, Samson SL, Guo S, Sun Y., Free PMC Article

Neuronal GHS-R Differentially Modulates Feeding Patterns under Normal and Obesogenic Conditions.
Lee JH, Xue B, Chen Z, Sun Y., Free PMC Article

Effect of Growth Hormone Secretagogue Receptor Deletion on Growth, Pulsatile Growth Hormone Secretion, and Meal Pattern in Male and Female Mice.
Labarthe A, Zizzari P, Fiquet O, Lebrun N, Veldhuis JD, Roelfsema F, Chauveau C, Bohlooly-Y M, Epelbaum J, Tolle V.

Selectively increasing GHS-R1a expression in dCA1 excitatory/inhibitory neurons have opposite effects on memory encoding.
Li N, Li N, Xu F, Yu M, Qiao Z, Zhou Y., Free PMC Article

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms.
Uriarte M, De Francesco PN, Fernández G, Castrogiovanni D, D'Arcangelo M, Imbernon M, Cantel S, Denoyelle S, Fehrentz JA, Praetorius J, Prevot V, Perello M.

Ghrelin signaling in dCA1 suppresses neuronal excitability and impairs memory acquisition via PI3K/Akt/GSK-3β cascades.
Li N, Xiao K, Mi X, Li N, Guo L, Wang X, Sun Y, Li GD, Zhou Y.

Discovery of a functionally selective ghrelin receptor (GHSR(1a)) ligand for modulating brain dopamine.
Gross JD, Kim DW, Zhou Y, Jansen D, Slosky LM, Clark NB, Ray CR, Hu X, Southall N, Wang A, Xu X, Barnaeva E, Wetsel WC, Ferrer M, Marugan JJ, Caron MG, Barak LS, Toth K., Free PMC Article

Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice.
Peris-Sampedro F, Stoltenborg I, Le May MV, Zigman JM, Adan RAH, Dickson SL., Free PMC Article

GHS-R1a deficiency mitigates lipopolysaccharide-induced lung injury in mice via the downregulation of macrophage activity.
Tanida R, Tsubouchi H, Yanagi S, Saito Y, Toshinai K, Miyazaki T, Takamura T, Nakazato M.

Antagonism of the ghrelin receptor type 1a in the rat brain induces status epilepticus in an electrical kindling model of epilepsy.
Azimzadeh M, Beheshti S.

Expression of ghrelin or growth hormone secretagogue receptor in the brain of postpartum stress mice.
Xing JW, Tian XY, Chen MM, Peng XH, Gao P.