| Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease. | Erythropoietin receptor signal is crucial for periodontal ligament stem cell-based tissue reconstruction in periodontal disease.
Zakaria MF, Sonoda S, Kato H, Ma L, Uehara N, Kyumoto-Nakamura Y, Sharifa MM, Yu L, Dai L, Yamauchi-Tomoda E, Aijima R, Yamaza H, Nishimura F, Yamaza T., Free PMC Article | 03/22/2024 |
| Hemolysis-driven IFNalpha production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease. | Hemolysis-driven IFNα production impairs erythropoiesis by negatively regulating EPO signaling in sickle cell disease.
Han Y, Gao C, Liu Y, Zhang H, Wang S, Zhao H, Bao W, Guo X, Vinchi F, Lobo C, Shi P, Mendelson A, Luchsinger L, Zhong H, Yazdanbakhsh K, An X., | 03/15/2024 |
| Erythropoietin receptor is a risk factor for prognosis: A potential biomarker in lung adenocarcinoma. | Erythropoietin receptor is a risk factor for prognosis: A potential biomarker in lung adenocarcinoma.
Zhang Y, Zhu Y, Wang S, Feng YC, Li H. | 11/18/2023 |
| [Update on the role and mechanism of erythropoietin receptor in acute kidney injury and repair or fibrosis]. | [Update on the role and mechanism of erythropoietin receptor in acute kidney injury and repair or fibrosis].
Han C, Liu Y, Wu YY, Yang B. | 03/6/2023 |
| Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia. | Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.
Takeda J, Yoshida K, Nakagawa MM, Nannya Y, Yoda A, Saiki R, Ochi Y, Zhao L, Okuda R, Qi X, Mori T, Kon A, Chiba K, Tanaka H, Shiraishi Y, Kuo MC, Kerr CM, Nagata Y, Morishita D, Hiramoto N, Hangaishi A, Nakazawa H, Ishiyama K, Miyano S, Chiba S, Miyazaki Y, Kitano T, Usuki K, Sezaki N, Tsurumi H, Miyawaki S, Maciejewski JP, Ishikawa T, Ohyashiki K, Ganser A, Heuser M, Thol F, Shih LY, Takaori-Kondo A, Makishima H, Ogawa S., Free PMC Article | 09/17/2022 |
| An inherited gain-of-function risk allele in EPOR predisposes to familial JAK2(V617F) myeloproliferative neoplasms. | An inherited gain-of-function risk allele in EPOR predisposes to familial JAK2(V617F) myeloproliferative neoplasms.
Rabadan Moraes G, Pasquier F, Marzac C, Deconinck E, Damanti CC, Leroy G, El-Khoury M, El Nemer W, Kiladjian JJ, Raslova H, Najman A, Vainchenker W, Marty C, Bellanné-Chantelot C, Plo I. | 07/2/2022 |
| Novel mutations in EPO-R and oxygen-dependent degradation (ODD) domain of EPAS1 genes-a causative reason for Congenital Erythrocytosis. | Novel mutations in EPO-R and oxygen-dependent degradation (ODD) domain of EPAS1 genes-a causative reason for Congenital Erythrocytosis.
Echambadi Loganathan S, Kattaru S, Chandrasekhar C, Vengamma B, Sarma PVGK. | 05/28/2022 |
| EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. | EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis.
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Maxwell Scalf S, Eastman AE, Chen JJ, Zhu LJ, Heuberger JAAC, Guo S, Koury MJ, Nordsborg NB, Socolovsky M., Free PMC Article | 01/15/2022 |
| Expression of the erythropoietin receptor in patients with proliferative diabetic retinopathy and its correlation with postoperative visual prognosis. | Expression of the erythropoietin receptor in patients with proliferative diabetic retinopathy and its correlation with postoperative visual prognosis.
He G, Zhou J, Yang X. | 08/21/2021 |
| Identification and Functional Analysis of EPOR(+) Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis. | Identification and Functional Analysis of EPOR(+) Tumor-Associated Macrophages in Human Osteosarcoma Lung Metastasis.
Li Y, Li M, Wei R, Wu J., Free PMC Article | 07/10/2021 |
| Upregulation of erythropoietin and erythropoietin receptor in castration-resistant progression of prostate cancer. | Upregulation of erythropoietin and erythropoietin receptor in castration-resistant progression of prostate cancer.
Ye C, Chen GH, Chen X, Qin SF, Shi MF, Zhou T., Free PMC Article | 06/26/2021 |
| Novel mutations in the EPO-R, VHL and EPAS1 genes in the Congenital Erythrocytosis patients. | Novel mutations in the EPO-R, VHL and EPAS1 genes in the Congenital Erythrocytosis patients.
Chandrasekhar C, Pasupuleti SK, Sarma PVGK. | 05/29/2021 |
| Gains of EPOR and ERG genes in adult erythroleukaemia. | Gains of EPOR and ERG genes in adult erythroleukaemia.
Adélaïde J, Cervera N, Guille A, Murati A, Chaffanet M, Mozziconacci MJ, Vey N, Birnbaum D, Gelsi-Boyer V. | 01/16/2021 |
| Mutation profile of JAK2, EPOR and CALR genes in polycythemia patients. | Mutation profile of JAK2, EPOR and CALR genes in polycythemia patients.
Anbinselvam A, Sidharthan N, Vidyadharan G, Kurian J, Biswas L. | 12/19/2020 |
| These results suggest that EPO-R+ MDS cells with ring sideroblasts or an SF3B1 mutation produce high levels of ERFE that may be associated with a reduction in hepcidin. | EPO-R+ myelodysplastic cells with ring sideroblasts produce high erythroferrone levels to reduce hepcidin expression in hepatic cells.
Miura S, Kobune M, Horiguchi H, Kikuchi S, Iyama S, Murase K, Goto A, Ikeda H, Takada K, Miyanishi K, Kato J. | 02/8/2020 |
| the methylation status of all selected cancer cell lines in exon 1 of EPOR gene | Methylation of the first exon in the erythropoietin receptor gene does not correlate with its mRNA and protein level in cancer cells.
Fecková B, Kimáková P, Ilkovičová L, Szentpéteriová E, Macejová M, Košuth J, Zulli A, Debeljak N, Hudler P, Jašek K, Kašubová I, Kubatka P, Solár P., Free PMC Article | 01/11/2020 |
| Our current study sheds light on the significance of EPOR signaling in erythroid cells and macrophages during erythrocytosis. Without expressing EPOR on their cell surface, macrophages expanded in response to EPO. | Expansion of EPOR-negative macrophages besides erythroblasts by elevated EPOR signaling in erythrocytosis mouse models.
Wang J, Hayashi Y, Yokota A, Xu Z, Zhang Y, Huang R, Yan X, Liu H, Ma L, Azam M, Bridges JP, Cancelas JA, Kalfa TA, An X, Xiao Z, Huang G., Free PMC Article | 07/27/2019 |
| these data suggest that increased EPO/EPO-R expression may play an important role in cervical carcinogenesis. EPO overexpression may promote Vasculogenic mimicry (VM) formation in cervical squamous cell carcinoma. | Vasculogenic Mimicry Formation Is Associated with Erythropoietin Expression but Not with Erythropoietin Receptor Expression in Cervical Squamous Cell Carcinoma.
Li YJ, Qing X, Tao QX, Xiang L, Gong L, Zhou TJ., Free PMC Article | 07/27/2019 |
| EPO/EpoR signaling in the kidney plays a critical role in acute kidney injury development, recovery, and progression to chronic kidney disease by acting on two main renal structures: renal tubules and peritubular capillaries. | Effects of erythropoietin receptor activity on angiogenesis, tubular injury, and fibrosis in acute kidney injury: a "U-shaped" relationship.
Shi M, Flores B, Li P, Gillings N, McMillan KL, Ye J, Huang LJ, Sidhu SS, Zhong YP, Grompe MT, Streeter PR, Moe OW, Hu MC., Free PMC Article | 04/27/2019 |
| To date, 28 variants of the EPOR and seven variants of the EPO gene have been associated with erythrocytosis or upper hematocrit. Sequence variants were also found to be present within regulatory regions. | Genetic variants of erythropoietin (EPO) and EPO receptor genes in familial erythrocytosis.
Vočanec D, Prijatelj T, Debeljak N, Kunej T., Free PMC Article | 04/6/2019 |
| Scribble deficiency reduces surface expression of Epo receptor but selectively retains survival signaling via Akt. | Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
Khalil S, Delehanty L, Grado S, Holy M, White Z 3rd, Freeman K, Kurita R, Nakamura Y, Bullock G, Goldfarb A., Free PMC Article | 03/30/2019 |
| Two novel missense mutations in EPOR gene causes erythrocytosis in two unrelated patients. | Two novel missense mutations in EPOR gene causes erythrocytosis in two unrelated patients.
Peroni E, Bertozzi I, Gherlinzoni F, Stefani PM, Lombardi A, Biagetti G, Fabris F, Randi ML. | 02/9/2019 |
| Here, we present two crystal structures of the human JAK2 FERM and SH2 domains bound to Leptin receptor (LEPR) and Erythropoietin receptor (EPOR), which identify a novel dimeric conformation for JAK2. | Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation.
Ferrao RD, Wallweber HJ, Lupardus PJ., Free PMC Article | 12/22/2018 |
| EpoR role in the proliferation and survival of non-small cell lung cancer cells | No erythropoietin-induced growth is observed in non-small cell lung cancer cells.
Frille A, Leithner K, Olschewski A, Olschewski H, Wohlkönig C, Hrzenjak A. | 08/11/2018 |
| These results highlight the high intrinsic specificity of transmembrane domain interactions, demonstrate that a single methyl group can dictate specificity, and define the minimal chemical difference that can modulate the specificity of transmembrane domain interactions and the activity of transmembrane proteins. | Single methyl groups can act as toggle switches to specify transmembrane Protein-protein interactions.
He L, Steinocher H, Shelar A, Cohen EB, Heim EN, Kragelund BB, Grigoryan G, DiMaio D., Free PMC Article | 06/9/2018 |