| Targeting the soluble epoxide hydrolase pathway as a novel therapeutic approach for the treatment of pain. | Targeting the soluble epoxide hydrolase pathway as a novel therapeutic approach for the treatment of pain.
Turnbull J, Chapman V. | 09/24/2024 |
| Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis. | Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis.
Pu Y, Cheng R, Zhang Q, Huang T, Lu C, Tang Z, Zhong Y, Wu L, Hammock BD, Hashimoto K, Luo Y, Liu Y., | 12/21/2023 |
| Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1alpha signalling pathway. | Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1α signalling pathway.
Gao L, Chen W, Li L, Li J, Kongling W, Zhang Y, Yang X, Zhao Y, Bai J, Wang F., Free PMC Article | 07/13/2023 |
| Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression. | Wide-spread enhancer effect of SNP rs2279590 on regulating epoxide hydrolase-2 and protein tyrosine kinase 2-beta gene expression.
Padhy B, Kapuganti RS, Hayat B, Mohanty PP, Alone DP. | 02/4/2023 |
| A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank. | A hypothesis-driven study to comprehensively investigate the association between genetic polymorphisms in EPHX2 gene and cardiovascular diseases: Findings from the UK Biobank.
Zhu X, Li Y, Yu T, Li S, Chen M. | 03/19/2022 |
| Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease. | Association of rs11780592 Polymorphism in the Human Soluble Epoxide Hydrolase Gene (EPHX2) with Oxidized LDL and Mortality in Patients with Diabetic Chronic Kidney Disease.
Roumeliotis S, Roumeliotis A, Stamou A, Panagoutsos S, Manolopoulos VG, Tsetsos F, Georgitsi M, Liakopoulos V., Free PMC Article | 01/8/2022 |
| Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients. | Preservation of epoxyeicosatrienoic acid bioavailability prevents renal allograft dysfunction and cardiovascular alterations in kidney transplant recipients.
Duflot T, Laurent C, Soudey A, Fonrose X, Hamzaoui M, Iacob M, Bertrand D, Favre J, Etienne I, Roche C, Coquerel D, Le Besnerais M, Louhichi S, Tarlet T, Li D, Brunel V, Morisseau C, Richard V, Joannidès R, Stanke-Labesque F, Lamoureux F, Guerrot D, Bellien J., Free PMC Article | 01/1/2022 |
| Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma. | Identification and validation of EPHX2 as a prognostic biomarker in hepatocellular carcinoma.
Zhan K, Bai Y, Liao S, Chen H, Kuang L, Luo Q, Lv L, Qiu L, Mei Z., Free PMC Article | 12/18/2021 |
| Clinical significance of EPHX2 deregulation in prostate cancer. | Clinical significance of EPHX2 deregulation in prostate cancer.
Liu MS, Zhao H, Xu CX, Xie PB, Wang W, Yang YY, Lee WH, Jin Y, Zhou HQ., Free PMC Article | 10/30/2021 |
| Soluble epoxide hydrolase as a therapeutic target for obesity-induced disorders: roles of gut barrier function involved. | Soluble epoxide hydrolase as a therapeutic target for obesity-induced disorders: roles of gut barrier function involved.
Zhang J, Tu M, Liu Z, Zhang G., Free PMC Article | 06/5/2021 |
| No impact of soluble epoxide hydrolase rs4149243, rs2234914 and rs751142 genetic variants on the development of type II diabetes and its hypertensive complication among Jordanian patients. | No impact of soluble epoxide hydrolase rs4149243, rs2234914 and rs751142 genetic variants on the development of type II diabetes and its hypertensive complication among Jordanian patients.
Khamees M, Jarrar Y, Al-Qirim T, Mahmoud IS, Hatmal MM, Alshaer W, Lee SJ. | 05/1/2021 |
| The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease. | The Multifaceted Role of Epoxide Hydrolases in Human Health and Disease.
Gautheron J, Jéru I., Free PMC Article | 04/3/2021 |
| Diabetes initiates cardiomyopathy through increased in sEH, reduced expression of CYP2J, and decreased levels of cardioprotective epoxyeicosatrienoic acids. | Role of Cytochrome p450 and Soluble Epoxide Hydrolase Enzymes and Their Associated Metabolites in the Pathogenesis of Diabetic Cardiomyopathy.
Maayah ZH, McGinn E, Al Batran R, Gopal K, Ussher JR, El-Kadi AOS. | 06/20/2020 |
| EPHX2 and RMI2 were noted as two novel key genes for cervical squamous cell carcinoma | Identification of EPHX2 and RMI2 as two novel key genes in cervical squamous cell carcinoma by an integrated bioinformatic analysis.
Liu J, Nie S, Gao M, Jiang Y, Wan Y, Ma X, Zhou S, Cheng W. | 06/6/2020 |
| Results indicate that soluble epoxide hydrolase (sEH, EPHX2) p.Lys55Arg and p.Arg287Gln polymorphisms do not significantly modify survival after an acute coronary syndrome (ACS) event. | Association between the EPHX2 p.Lys55Arg polymorphism and prognosis following an acute coronary syndrome.
Oni-Orisan A, Cresci S, Jones PG, Theken KN, Spertus JA, Lee CR., Free PMC Article | 03/2/2019 |
| Daunorubicin induces cardiotoxicity through a sEH-mediated epoxyeicosatrienoic acids degradation-dependent mechanism. | The Role of Soluble Epoxide Hydrolase Enzyme on Daunorubicin-Mediated Cardiotoxicity.
Maayah ZH, Abdelhamid G, Elshenawy OH, El-Sherbeni AA, Althurwi HN, McGinn E, Dawood D, Alammari AH, El-Kadi AOS. | 02/9/2019 |
| Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression | Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression.
Qiu YE, Qin J, Luo Y, Qin SL, Mu YF, Cun R, Jiang HL, Chen JJ, Yu MH, Zhong M. | 02/2/2019 |
| the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of diabetic nephropathy in the Chinese type 2 diabetes population, which could be modulated by homocysteine level status. | Association of EPHX2 R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients.
Ma L, Yan M, Kong X, Jiang Y, Zhao T, Zhao H, Liu Q, Zhang H, Liu P, Cao Y, Li P., Free PMC Article | 10/6/2018 |
| Single nucleotide polymorphism of EPHX2 rs751141 is associated with Early Neurological Deterioration. | Epoxyeicosatrienoic Acids are Mediated by EPHX2 Variants and may be a Predictor of Early Neurological Deterioration in Acute Minor Ischemic Stroke.
Yi X, Lin J, Li J, Zhou Q, Han Z., Free PMC Article | 08/4/2018 |
| The activity of Ephx2 promoter-coding luciferase was significantly attenuated in HEK293T cells treated with 17beta-E2. | Estrogen-dependent epigenetic regulation of soluble epoxide hydrolase via DNA methylation.
Yang YM, Sun D, Kandhi S, Froogh G, Zhuge J, Huang W, Hammock BD, Huang A., Free PMC Article | 08/4/2018 |
| hypomethylation of the promoter region of EPHX2 and K55R polymorphism were associated with significant increased risk of pre-eclampsia. | Association between the soluble epoxide hydrolase gene and preeclampsia.
Sari I, Pinarbasi H, Pinarbasi E, Yildiz C. | 07/21/2018 |
| Study demonstrated an isolated gene change, sEH R287Q, in a core family of familial hypercholesterolemia (FH). The results showed that sEH R287Q decreased the expression level and hydrolase activity of sEH, decreased the binding of LDL to LDLR and LDL internalization in cultured hepatocyte cell line BEL-7402. | Role of sEH R287Q in LDLR expression, LDL binding to LDLR and LDL internalization in BEL-7402 cells.
Tang L, Wang G, Jiang L, Chen P, Wang W, Chen J, Wang L. | 06/9/2018 |
| Soluble epoxide hydrolase plays role in the choroidal neovascularization | Chemical Proteomics Reveals Soluble Epoxide Hydrolase as a Therapeutic Target for Ocular Neovascularization.
Sulaiman RS, Park B, Sheik Pran Babu SP, Si Y, Kharwadkar R, Mitter SK, Lee B, Sun W, Qi X, Boulton ME, Meroueh SO, Fei X, Seo SY, Corson TW., Free PMC Article | 05/5/2018 |
| Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors. | Pseudoexfoliation and Alzheimer's associated CLU risk variant, rs2279590, lies within an enhancer element and regulates CLU, EPHX2 and PTK2B gene expression.
Padhy B, Hayat B, Nanda GG, Mohanty PP, Alone DP. | 03/24/2018 |
| Results showed that among type 2 diabetic patients, the combined effect of MTHFR TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group. | Synergistic Effect of the MTHFR C677T and EPHX2 G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients.
Ma L, Jiang Y, Kong X, Yan M, Zhao T, Zhao H, Liu Q, Zhang H, Cao Y, Li P., Free PMC Article | 02/3/2018 |