| Astrocytic NKCC1 inhibits seizures by buffering Cl[-] and antagonizing neuronal NKCC1 at GABAergic synapses. | Astrocytic NKCC1 inhibits seizures by buffering Cl(-) and antagonizing neuronal NKCC1 at GABAergic synapses.
Nguyen TD, Ishibashi M, Sinha AS, Watanabe M, Kato D, Horiuchi H, Wake H, Fukuda A. | 12/20/2023 |
| In vitro investigation of the effect of proinflammatory cytokines on mouse choroid plexus membrane transporters Ncbe and NKCC1. | In vitro investigation of the effect of proinflammatory cytokines on mouse choroid plexus membrane transporters Ncbe and NKCC1.
Johnsen LØ, Friis KA, Damkier HH., Free PMC Article | 11/18/2023 |
| Slc12a2 loss in insulin-secreting beta-cells links development of overweight and metabolic dysregulation to impaired satiation control of feeding. | Slc12a2 loss in insulin-secreting β-cells links development of overweight and metabolic dysregulation to impaired satiation control of feeding.
Rathod YD, Abdelgawad R, Hübner CA, Di Fulvio M., Free PMC Article | 11/2/2023 |
| Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1. | Age-appropriate potassium clearance from perinatal cerebrospinal fluid depends on choroid plexus NKCC1.
Fame RM, Xu H, Pragana A, Lehtinen M., Free PMC Article | 06/23/2023 |
| Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development. | Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development.
Kurki SN, Uvarov P, Pospelov AS, Trontti K, Hübner AK, Srinivasan R, Watanabe M, Hovatta I, Hübner CA, Kaila K, Virtanen MA., Free PMC Article | 05/17/2023 |
| Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex. | Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex.
Takezawa Y, Langton R, Baule SM, Zimmerman MB, Baek S, Glykys J., Free PMC Article | 02/22/2023 |
| Beta-Amyloid (Abeta1-42) Increases the Expression of NKCC1 in the Mouse Hippocampus. | Beta-Amyloid (Aβ(1-42)) Increases the Expression of NKCC1 in the Mouse Hippocampus.
Lam P, Vinnakota C, Guzmán BC, Newland J, Peppercorn K, Tate WP, Waldvogel HJ, Faull RLM, Kwakowsky A., Free PMC Article | 05/14/2022 |
| The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner. | The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner.
Tóth K, Lénárt N, Berki P, Fekete R, Szabadits E, Pósfai B, Cserép C, Alatshan A, Benkő S, Kiss D, Hübner CA, Gulyás A, Kaila K, Környei Z, Dénes Á., Free PMC Article | 03/5/2022 |
| Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome. | Restoring neuronal chloride homeostasis with anti-NKCC1 gene therapy rescues cognitive deficits in a mouse model of Down syndrome.
Parrini M, Naskar S, Alberti M, Colombi I, Morelli G, Rocchi A, Nanni M, Piccardi F, Charles S, Ronzitti G, Mingozzi F, Contestabile A, Cancedda L., Free PMC Article | 02/19/2022 |
| Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy. | Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Hampel P, Johne M, Gailus B, Vogel A, Schidlitzki A, Gericke B, Töllner K, Theilmann W, Käufer C, Römermann K, Kaila K, Löscher W. | 01/8/2022 |
| A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior. | A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior.
Graf J, Zhang C, Marguet SL, Herrmann T, Flossmann T, Hinsch R, Rahmati V, Guenther M, Frahm C, Urbach A, Neves RM, Witte OW, Kiebel SJ, Isbrandt D, Hübner CA, Holthoff K, Kirmse K., Free PMC Article | 11/22/2021 |
| Axonal GABAA stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity. | Axonal GABA(A) stabilizes excitability in unmyelinated sensory axons secondary to NKCC1 activity.
Bonalume V, Caffino L, Castelnovo LF, Faroni A, Liu S, Hu J, Milanese M, Bonanno G, Sohns K, Hoffmann T, De Col R, Schmelz M, Fumagalli F, Magnaghi V, Carr R. | 10/30/2021 |
| Oligodendrocytic Na(+)-K(+)-Cl(-) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain. | Oligodendrocytic Na(+)-K(+)-Cl(-) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain.
Yamazaki Y, Abe Y, Fujii S, Tanaka KF., Free PMC Article | 09/25/2021 |
| Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation. | Novel Human NKCC1 Mutations Cause Defects in Goblet Cell Mucus Secretion and Chronic Inflammation.
Koumangoye R, Omer S, Kabeer MH, Delpire E., Free PMC Article | 05/8/2021 |
| A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency. | A Drosophila screen identifies NKCC1 as a modifier of NGLY1 deficiency.
Talsness DM, Owings KG, Coelho E, Mercenne G, Pleinis JM, Partha R, Hope KA, Zuberi AR, Clark NL, Lutz CM, Rodan AR, Chow CY., Free PMC Article | 04/3/2021 |
| Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development. | Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development.
Xu H, Fame RM, Sadegh C, Sutin J, Naranjo C, Della Syau, Cui J, Shipley FB, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Warf BC, Lin PY, Lehtinen MK., Free PMC Article | 02/6/2021 |
| Differential expression of Na(+)/K(+)/Cl(-) cotransporter 1 in neurons and glial cells within the superficial spinal dorsal horn of rodents. | Differential expression of Na(+)/K(+)/Cl(-) cotransporter 1 in neurons and glial cells within the superficial spinal dorsal horn of rodents.
Javdani F, Hegedűs K, Miranda CO, Hegyi Z, Holló K, Antal M., Free PMC Article | 01/9/2021 |
| Aquaporin 1 and the Na(+)/K(+)/2Cl(-) cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system. | Aquaporin 1 and the Na(+)/K(+)/2Cl(-) cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system.
Li Q, Aalling NN, Förstera B, Ertürk A, Nedergaard M, Møllgård K, Xavier ALR., Free PMC Article | 11/21/2020 |
| Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. | Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.
Lee M, Liu YC, Chen C, Lu CH, Lu ST, Huang TN, Hsu MT, Hsueh YP, Cheng PL., Free PMC Article | 09/19/2020 |
| responses to capsaicin and hyperosmotic solution point to a functional role for TRPV1 channels in mouse lens. Lack of NKCC1 phosphorylation and Rb(+) uptake responses in TRPV1(-/-) mouse epithelium reinforces the notion that a hyperosmotic challenge causes TRPV1-dependent NKCC1 activation | TRPV1 activation stimulates NKCC1 and increases hydrostatic pressure in the mouse lens.
Shahidullah M, Mandal A, Mathias RT, Gao J, Križaj D, Redmon S, Delamere NA., Free PMC Article | 08/13/2020 |
| Results show that the serine/threonine-protein kinase WNK4 (WNK4)-serine/threonine-protein kinase 39 (SPAK)-NKCC1 transport protein (NKCC1) cascade plays an important role in modulating macrophage activation to regulate lipopolysaccharides (LPS)-induced lung inflammation and lung injury. | WNK4-SPAK modulates lipopolysaccharide-induced macrophage activation.
Hung CM, Peng CK, Yang SS, Shui HA, Huang KL. | 08/1/2020 |
| NKCC1 provides a long-sought link connecting cell volume (size) to cell mass regulation. | The Ion Transporter NKCC1 Links Cell Volume to Cell Mass Regulation by Suppressing mTORC1.
Demian WL, Persaud A, Jiang C, Coyaud É, Liu S, Kapus A, Kafri R, Raught B, Rotin D. | 07/4/2020 |
| Expression of Na-K-2Cl cotransporter-1 was elevated in the striatum of Huntington disease mouse models. | Enhanced Na(+) -K(+) -2Cl(-) cotransporter 1 underlies motor dysfunction in huntington's disease.
Hsu YT, Chang YG, Liu YC, Wang KY, Chen HM, Lee DJ, Yang SS, Tsai CH, Lien CC, Chern Y. | 03/14/2020 |
| Our results show that cytosolic Na(+) in mouse cortical astrocytes can vary considerably and depends greatly on the concentrations of HCO3 (-) and K(+) , attributable to the activity of the Na(+) -K(+) -ATPase, of NBCe1 and NKCC1 | Cytosolic sodium regulation in mouse cortical astrocytes and its dependence on potassium and bicarbonate.
Noor ZN, Deitmer JW, Theparambil SM. | 10/5/2019 |
| NKCC1 plays an essential role in myogenesis and exercise-induced skeletal muscle hypertrophy. | Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy.
Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, Ando F, Mori Y, Takahashi D, Yoshizaki Y, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Furuichi Y, Fujii NL, Sohara E, Rai T, Uchida S., Free PMC Article | 07/27/2019 |