| The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells. | The transcriptional regulator Sin3A balances IL-17A and Foxp3 expression in primary CD4 T cells.
Perucho L, Icardi L, Di Simone E, Basso V, Agresti A, Vilas Zornoza A, Lozano T, Prosper F, Lasarte JJ, Mondino A., Free PMC Article | 05/8/2023 |
| An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak beta-Cell Mass Acquisition. | An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β-Cell Mass Acquisition.
Bartolomé A, Ravussin Y, Yu J, Ferrante AW, Pajvani UB., Free PMC Article | 01/14/2023 |
| Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling. | Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.
Bridi M, Schoch H, Florian C, Poplawski SG, Banerjee A, Hawk JD, Porcari GS, Lejards C, Hahn CG, Giese KP, Havekes R, Spruston N, Abel T., Free PMC Article | 06/26/2021 |
| The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex. | The neuronal transcription factor Myt1L interacts via a conserved motif with the PAH1 domain of Sin3 to recruit the Sin3L/Rpd3L histone deacetylase complex.
Marcum RD, Radhakrishnan I., Free PMC Article | 05/8/2021 |
| Coregulator Sin3a Promotes Postnatal Murine beta-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response. | Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca(2+) Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response.
Yang X, Graff SM, Heiser CN, Ho KH, Chen B, Simmons AJ, Southard-Smith AN, David G, Jacobson DA, Kaverina I, Wright CVE, Lau KS, Gu G., Free PMC Article | 10/24/2020 |
| results indicate a vital role of Sin3a in safeguarding the developmental progression through the morula-to-blastocyst transition via Hdac1. | Sin3a regulates the developmental progression through morula-to-blastocyst transition via Hdac1.
Zhao P, Li S, Wang H, Dang Y, Wang L, Liu T, Wang S, Li X, Zhang K., Free PMC Article | 05/30/2020 |
| Sin3a interacted with Tet1 to facilitate the transcription of a set of their co-target genes in embryonic stem cells. | Sin3a-Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency.
Zhu F, Zhu Q, Ye D, Zhang Q, Yang Y, Guo X, Liu Z, Jiapaer Z, Wan X, Wang G, Chen W, Zhu S, Jiang C, Shi W, Kang J., Free PMC Article | 07/27/2019 |
| These findings together suggest that SIN3A has a critical role in regulation of synaptic plasticity and might act as a potential therapeutic target to rescue memory decline during amnesia and other neuropsychiatric pathologies | Transcriptional co-repressor SIN3A silencing rescues decline in memory consolidation during scopolamine-induced amnesia.
Srivas S, Thakur MK. | 05/11/2019 |
| Members of the SIN3A/HDAC2 corepressor complex are enriched in an extended NANOG interactome. | The SIN3A/HDAC Corepressor Complex Functionally Cooperates with NANOG to Promote Pluripotency.
Saunders A, Huang X, Fidalgo M, Reimer MH Jr, Faiola F, Ding J, Sánchez-Priego C, Guallar D, Sáenz C, Li D, Wang J., Free PMC Article | 12/2/2017 |
| The co-repressor protein Sin3a is crucial for lung endoderm development. Loss of Sin3a in early foregut endoderm led to a specific and profound defect in lung development with lung buds failing to undergo branching morphogenesis and progressive atrophy of the proximal lung endoderm with complete epithelial loss at later stages of development. | Sin3a regulates epithelial progenitor cell fate during lung development.
Yao C, Carraro G, Konda B, Guan X, Mizuno T, Chiba N, Kostelny M, Kurkciyan A, David G, McQualter JL, Stripp BR., Free PMC Article | 09/30/2017 |
| Taken together, Fam60a is an essential core subunit of a variant Sin3a-Hdac complex in embryonic stem cells that is required to promote rapid proliferation and prevent unscheduled differentiation. | Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.
Streubel G, Fitzpatrick DJ, Oliviero G, Scelfo A, Moran B, Das S, Munawar N, Watson A, Wynne K, Negri GL, Dillon ET, Jammula S, Hokamp K, O'Connor DP, Pasini D, Cagney G, Bracken AP., Free PMC Article | 08/12/2017 |
| TGF-beta1-induced inhibition of PPARgamma transcription depends on formation of a functional transcriptional regulatory complex that includes Smad3, mSin3A and HDAC1 at the PPARgamma promoter. | Smad3-mSin3A-HDAC1 Complex is Required for TGF-β1-Induced Transcriptional Inhibition of PPARγ in Mouse Cardiac Fibroblasts.
Gong K, Chen M, Li R, He Y, Zhu H, Yao D, Oparil S, Zhang Z. | 02/18/2017 |
| Sin3a mRNA is recruited during maturation and that inhibiting its recruitment not only inhibits development beyond the 2-cell stage but also compromises the fidelity of reprogramming gene expression | Maternal SIN3A regulates reprogramming of gene expression during mouse preimplantation development.
Jimenez R, Melo EO, Davydenko O, Ma J, Mainigi M, Franke V, Schultz RM., Free PMC Article | 07/16/2016 |
| Report role of myocardial mSin3A/HDAC1/2 complex in mediating the beneficial effects of exercise in diabetic cardiomyopathy. | Exercise and diabetes have opposite effects on the assembly and O-GlcNAc modification of the mSin3A/HDAC1/2 complex in the heart.
Cox EJ, Marsh SA., Free PMC Article | 04/4/2015 |
| SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor. | SIN3A, generally regarded as a transcriptional repressor, is required for induction of gene transcription by the aryl hydrocarbon receptor.
Solaimani P, Wang F, Hankinson O., Free PMC Article | 02/14/2015 |
| As a result of differences in the components and targets of the Rest complex, its functional roles may differ in embryonic stem cells and epiblast stem cells. | A comparison of the rest complex binding patterns in embryonic stem cells and epiblast stem cells.
Seki M, Masaki H, Arauchi T, Nakauchi H, Sugano S, Suzuki Y., Free PMC Article | 01/17/2015 |
| Treatment with GlcN, in contrast, inhibits LPS-ind inflammation and decreased LPS-mediated recruitment of OGT, mSin3A, and HDACs. | O-GlcNAc transferase inhibits LPS-mediated expression of inducible nitric oxide synthase through an increased interaction with mSin3A in RAW264.7 cells.
Hwang SY, Hwang JS, Kim SY, Han IO. | 02/15/2014 |
| Within the male germline, Sin3a is required for the mitotic reentry of gonocytes, but is dispensable for the maintenance of differentiating spermatogonia and subsequent spermatogenic processes. | Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia.
Gallagher SJ, Kofman AE, Huszar JM, Dannenberg JH, DePinho RA, Braun RE, Payne CJ., Free PMC Article | 01/26/2013 |
| Sin3A-deleted testes exhibit a Sertoli-cell only phenotype, consistent with the absolute requirement for Sin3A in germ cells' development and/or viability. | Chromatin associated Sin3A is essential for male germ cell lineage in the mouse.
Pellegrino J, Castrillon DH, David G., Free PMC Article | 11/3/2012 |
| Sin3 has an important role in the regulation of cell cycle kinetics of the myogenic progenitor cell population | Sin3 interacts with Foxk1 and regulates myogenic progenitors.
Shi X, Garry DJ., Free PMC Article | 10/13/2012 |
| ARID4B physically interacts with the breast cancer metastasis suppressor BRMS1, and we detected differential binding of the Arid4b alleles to mSIN3A and mSDS3 | Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.
Winter SF, Lukes L, Walker RC, Welch DR, Hunter KW., Free PMC Article | 09/29/2012 |
| Results indicate that Sin3a protects the genomic integrity of pluripotent embryonic cells and governs their unusual cell cycle. | Sin3a is essential for the genome integrity and viability of pluripotent cells.
McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD., Free PMC Article | 05/26/2012 |
| Sin3a causes deacetylation of c-Myc protein to directly repress c-Myc activity. | The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis.
Nascimento EM, Cox CL, MacArthur S, Hussain S, Trotter M, Blanco S, Suraj M, Nichols J, Kübler B, Benitah SA, Hendrich B, Odom DT, Frye M., Free PMC Article | 01/28/2012 |
| show using NMR that the mSin3A PAH3-SAP30 SID complex can bind to nucleic acids, hinting at a role for a nucleolar localization sequence in the SID alphaA helix in targeting the Rpd3L/Sin3L complex for silencing ribosomal RNA genes | Structure of the 30-kDa Sin3-associated protein (SAP30) in complex with the mammalian Sin3A corepressor and its role in nucleic acid binding.
Xie T, He Y, Korkeamaki H, Zhang Y, Imhoff R, Lohi O, Radhakrishnan I., Free PMC Article | 10/15/2011 |
| analysis indicates PSF within the PER complex recruits SIN3A, a scaffold for assembly of transcriptional inhibitory complexes, and the PER complex thereby rhythmically delivers histone deacetylases to the Per1 promoter, which repress Per1 transcription | A molecular mechanism for circadian clock negative feedback.
Duong HA, Robles MS, Knutti D, Weitz CJ., Free PMC Article | 07/2/2011 |