| Structural basis of semaphorin-plexin cis interaction. | Structural basis of semaphorin-plexin cis interaction.
Rozbesky D, Verhagen MG, Karia D, Nagy GN, Alvarez L, Robinson RA, Harlos K, Padilla-Parra S, Pasterkamp RJ, Jones EY., Free PMC Article | 04/13/2021 |
| Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins. | Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins.
Lee H, Beilhartz GL, Kucharska I, Raman S, Cui H, Lam MHY, Liang H, Rubinstein JL, Schramek D, Julien JP, Melnyk RA, Taipale M., Free PMC Article | 04/3/2021 |
| Study shows remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice. | Remarkable complexity and variability of corticospinal tract defects in adult Semaphorin 6A knockout mice.
Okada T, Keino-Masu K, Suto F, Mitchell KJ, Masu M. | 06/27/2020 |
| Data show that opposing effects of neurotrophic brain-derived neurotrophic factor (BDNF) and repulsive Sema6a Semaphorins (Sema6a) factors regulate the sensory innervation of the mammary gland. | Balance between BDNF and Semaphorins gates the innervation of the mammary gland.
Sar Shalom H, Goldner R, Golan-Vaishenker Y, Yaron A., Free PMC Article | 04/25/2020 |
| We find that the transmembrane protein semaphorin 6A (Sema6A) is required for the formation of axonal projections from the medial terminal nucleus to the nucleus of the optic tract | Genetic access to neurons in the accessory optic system reveals a role for Sema6A in midbrain circuitry mediating motion perception.
Lilley BN, Sabbah S, Hunyara JL, Gribble KD, Al-Khindi T, Xiong J, Wu Z, Berson DM, Kolodkin AL., Free PMC Article | 04/18/2020 |
| These findings implicate Semaphorin-6A - Plexin-A2/Plexin-A4 interactions in dorsal lateral geniculate nucleus axon guidance and in the spatiotemporal organization of guidepost cell populations in the mammalian subpallium. | Semaphorin-Plexin signaling influences early ventral telencephalic development and thalamocortical axon guidance.
Mitsogiannis MD, Little GE, Mitchell KJ., Free PMC Article | 03/31/2018 |
| Shear stress-regulated miR-27b promotes the interaction of endothelial cells with pericytes, partly by repressing SEMA6A and SEMA6D. | Shear stress-regulated miR-27b controls pericyte recruitment by repressing SEMA6A and SEMA6D.
Demolli S, Doddaballapur A, Devraj K, Stark K, Manavski Y, Eckart A, Zehendner CM, Lucas T, Korff T, Hecker M, Massberg S, Liebner S, Kaluza D, Boon RA, Dimmeler S. | 03/3/2018 |
| mutations in Sema6A, and/or possibly interacting genes, may result in dysfunction at the level of neuronal networks with associated behavioural phenotypes of relevance to neuropsychiatric disorders | Semaphorin 6A knockout mice display abnormalities across ethologically-based topographies of exploration and in motor learning.
Håkansson K, Runker AE, O'Sullivan GJ, Mitchell KJ, Waddington JL, O'Tuathaigh CM. | 12/16/2017 |
| The experiments reveal the complex nature of Sema6A biochemical functions and the molecular logic of the context-dependent interactions between Sema6A and PlxnA2. | Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology.
Perez-Branguli F, Zagar Y, Shanley DK, Graef IA, Chédotal A, Mitchell KJ., Free PMC Article | 08/19/2017 |
| Using time-lapse videomicroscopy we provide evidence that Sema6A/PlexinA2 signaling participates to interkinetic nuclear migration of retinal progenitor cell | PlexinA2 and Sema6A are required for retinal progenitor cell migration.
Belle M, Parray A, Belle M, Chédotal A, Nguyen-Ba-Charvet KT. | 02/18/2017 |
| findings reveal a unique function of Nrf2 in reprogramming ischemic tissue toward neurovascular repair via Sema6A regulation, providing a potential therapeutic strategy for ischemic retinal and CNS diseases | Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A.
Wei Y, Gong J, Xu Z, Thimmulappa RK, Mitchell KL, Welsbie DS, Biswal S, Duh EJ., Free PMC Article | 06/4/2016 |
| Tangential migration is selectively altered in cerebellar neurons of Sema6A knockouts. | Time-lapse analysis of tangential migration in Sema6A and PlexinA2 knockouts.
Renaud J, Chédotal A. | 07/25/2015 |
| semaphorin 6A is expressed in On starburst amacrine cell. | On and off retinal circuit assembly by divergent molecular mechanisms.
Sun LO, Jiang Z, Rivlin-Etzion M, Hand R, Brady CM, Matsuoka RL, Yau KW, Feller MB, Kolodkin AL., Free PMC Article | 11/16/2013 |
| Sema6A expressed in oligodendrocyte precursor cells is involved in their autonomous migration through ligand-receptor interaction with Plexin-A4 expressed in surrounding cells. | A role of Sema6A expressed in oligodendrocyte precursor cells.
Okada A, Tomooka Y. | 08/3/2013 |
| The results of this study suggested that Sema6A might have a role in myelination by controlling oligodendrocyte differentiation. | Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination.
Bernard F, Moreau-Fauvarque C, Heitz-Marchaland C, Zagar Y, Dumas L, Fouquet S, Lee X, Shao Z, Mi S, Chédotal A. | 01/26/2013 |
| Adult Sema6A-null mice exhibit reduced tumor, matrigel, and choroidal angiogenesis compared with controls. Here we show that it also regulates vascular development and adult angiogenesis. | Semaphorin 6A regulates angiogenesis by modulating VEGF signaling.
Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, Li X, Tosato G., Free PMC Article | 01/26/2013 |
| null mutations in Sema6A or PlexinA4 (PlexA4) exhibit a pronounced defect in OPL stratification of horizontal cell axons without any apparent deficits in bipolar cell dendrite or photoreceptor axon targeting. | Guidance-cue control of horizontal cell morphology, lamination, and synapse formation in the mammalian outer retina.
Matsuoka RL, Jiang Z, Samuels IS, Nguyen-Ba-Charvet KT, Sun LO, Peachey NS, Chédotal A, Yau KW, Kolodkin AL., Free PMC Article | 07/28/2012 |
| Mice with mutations in Sema6A or the interacting genes may thus represent a highly informative model for how neurodevelopmental defects can lead to anatomical dysconnectivity. | Mutation of Semaphorin-6A disrupts limbic and cortical connectivity and models neurodevelopmental psychopathology.
Rünker AE, O'Tuathaigh C, Dunleavy M, Morris DW, Little GE, Corvin AP, Gill M, Henshall DC, Waddington JL, Mitchell KJ., Free PMC Article | 04/7/2012 |
| the transmembrane semaphorin Sema6A signals through its receptor PlexinA4 (PlexA4) to control lamina-specific neuronal stratification in the mouse retina | Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina.
Matsuoka RL, Nguyen-Ba-Charvet KT, Parray A, Badea TC, Chédotal A, Kolodkin AL., Free PMC Article | 03/5/2011 |
| crystal structures of cognate complexes of the semaphorin-binding regions of plexins B1 and A2 with semaphorin ectodomains (human PLXNB1(1-2)-SEMA4D(ecto) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto) | Structural basis of semaphorin-plexin signalling.
Janssen BJ, Robinson RA, Pérez-Brangulí F, Bell CH, Mitchell KJ, Siebold C, Jones EY., Free PMC Article | 01/1/2011 |
| regulates lamina-restricted projection of hippocampal mossy fiber.(review) | [Semaphorin/plexin signal regulates lamina-restricted projection of hippocampal mossy fiber].
Suto F. | 01/1/2011 |
| crystal structures of the semaphorin 6A (Sema6A) receptor-binding fragment and the plexin A2 (PlxnA2) ligand-binding fragment in both their pre-signalling (that is, before binding) and signalling (after complex formation) states | Structural basis for semaphorin signalling through the plexin receptor.
Nogi T, Yasui N, Mihara E, Matsunaga Y, Noda M, Yamashita N, Toyofuku T, Uchiyama S, Goshima Y, Kumanogoh A, Takagi J. | 01/1/2011 |
| suggesting that a Sema6A-Plexin-A4 cis interaction serves as an inhibitory mechanism. | Cis interaction between Semaphorin6A and Plexin-A4 modulates the repulsive response to Sema6A.
Haklai-Topper L, Mlechkovich G, Savariego D, Gokhman I, Yaron A., Free PMC Article | 08/30/2010 |
| Data show that Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points. | Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points.
Rünker AE, Little GE, Suto F, Fujisawa H, Mitchell KJ., Free PMC Article | 01/21/2010 |
| Centrosome-nucleus coupling and coordinated motility were strongly perturbed in Sema6a-deficient granule cells suggesting that semaphorin-plexin signaling modulates cell migration by controlling centrosome positioning. | Plexin-A2 and its ligand, Sema6A, control nucleus-centrosome coupling in migrating granule cells.
Renaud J, Kerjan G, Sumita I, Zagar Y, Georget V, Kim D, Fouquet C, Suda K, Sanbo M, Suto F, Ackerman SL, Mitchell KJ, Fujisawa H, Chédotal A. | 01/21/2010 |