| Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice. | Vascular Sema3E-Plexin-D1 Signaling Reactivation Promotes Post-stroke Recovery through VEGF Downregulation in Mice.
Yu R, Kim NS, Li Y, Jeong JY, Park SJ, Zhou B, Oh WJ., Free PMC Article | 05/7/2022 |
| CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway. | CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway.
Boulan B, Ravanello C, Peyrel A, Bosc C, Delphin C, Appaix F, Denarier E, Kraut A, Jacquier-Sarlin M, Fournier A, Andrieux A, Gory-Fauré S, Deloulme JC., Free PMC Article | 01/29/2022 |
| Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence. | Semaphorin 3E deficiency dysregulates dendritic cell functions: In vitro and in vivo evidence.
Movassagh H, Shan L, Koussih L, Alamri A, Ariaee N, Kung SKP, Gounni AS., Free PMC Article | 11/22/2021 |
| Semaphorin 3E Promotes Susceptibility to Leishmania major Infection in Mice by Suppressing CD4(+) Th1 Cell Response. | Semaphorin 3E Promotes Susceptibility to Leishmania major Infection in Mice by Suppressing CD4(+) Th1 Cell Response.
Ikeogu NM, Edechi CA, Akaluka GN, Feiz-Barazandeh A, Zayats RR, Salako ES, Onwah SS, Onyilagha C, Jia P, Mou Z, Shan L, Murooka TT, Gounni AS, Uzonna JE. | 08/7/2021 |
| Semaphorin 3E Protects against Chlamydial Infection by Modulating Dendritic Cell Functions. | Semaphorin 3E Protects against Chlamydial Infection by Modulating Dendritic Cell Functions.
Thomas R, Wang S, Shekhar S, Peng Y, Qiao S, Zhang C, Shan L, Movassagh H, Gounni AS, Yang J, Yang X. | 08/7/2021 |
| data show that Sema3E plays an essential role in dampening the early inflammatory response to LPS by regulating macrophage function, suggesting an essential role of this pathway in macrophage inflammatory response | Semaphorin 3E Regulates the Response of Macrophages to Lipopolysaccharide-Induced Systemic Inflammation.
Mohammed A, Okwor I, Shan L, Onyilagha C, Uzonna JE, Gounni AS. | 08/1/2020 |
| SEMA3E deficiency could be a predisposing factor that makes airway smooth muscle cells prone to a hypercontractile phenotype and leading to heightened airway narrowing and hyperresponsiveness. | Genetic Deletion of Semaphorin 3E Aggravates Airway Contraction in a Mouse Model of Allergic Asthma.
Movassagh H, Ojo OO, Mohammed A, Shan L, Halayko AJ, Gounni AS. | 12/28/2019 |
| Our current work revealed a novel role of Sema-3E in limiting NK-cell migrations toward immature DC in NK-DC crosstalk. | Semaphorin-3E Produced by Immature Dendritic Cells Regulates Activated Natural Killer Cells Migration.
Alamri A, Rahman R, Zhang M, Alamri A, Gounni AS, Kung SKP., Free PMC Article | 07/13/2019 |
| Results describe new roles of Sema3E/PlexinD1 signaling during development and in adult hippocampal formation and provide evidence for an implication of Sema3E/PlexinD1 in the layer-specific development of the entorhino-hippocampal connection. | New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation.
Mata A, Gil V, Pérez-Clausell J, Dasilva M, González-Calixto MC, Soriano E, García-Verdugo JM, Sanchez-Vives MV, Del Río JA., Free PMC Article | 12/22/2018 |
| that retinoic acid receptor-related orphan receptor alpha is a novel transcriptional regulator of SEMA3E-mediated neurovascular coupling in pathological retinal angiogenesis | RORα modulates semaphorin 3E transcription and neurovascular interaction in pathological retinal angiogenesis.
Sun Y, Liu CH, Wang Z, Meng SS, Burnim SB, SanGiovanni JP, Kamenecka TM, Solt LA, Chen J., Free PMC Article | 10/21/2017 |
| The data indicate that exposure to house dust mite markedly reduces Sema3E expression in mouse airways. More important, replenishment of Sema3E by intranasal administration of exogenous Sema3E protects mice from allergic asthma by reducing eosinophilic inflammation, serum IgE level, and T helper cell 2/T helper cell 17 cytokine response. | Semaphorin 3E Alleviates Hallmarks of House Dust Mite-Induced Allergic Airway Disease.
Movassagh H, Shan L, Duke-Cohan JS, Halayko AJ, Uzonna JE, Gounni AS. | 10/14/2017 |
| findings identify Sema3E as a novel regulatory molecule in allergic asthma that acts upstream of proallergic events and suggest that targeting this molecule could be a novel approach to treat allergic asthma. | Semaphorin 3E Deficiency Exacerbates Airway Inflammation, Hyperresponsiveness, and Remodeling in a Mouse Model of Allergic Asthma.
Movassagh H, Shan L, Mohammed A, Halayko AJ, Gounni AS. | 09/9/2017 |
| Our results demonstrate that sema3e/plexin D1 modulates IS formation and Ag-scanning activities of thymocytes within thymic tissues. | Sema3e/Plexin D1 Modulates Immunological Synapse and Migration of Thymocytes by Rap1 Inhibition.
Ueda Y, Kondo N, Ozawa M, Yasuda K, Tomiyama T, Kinashi T. | 08/6/2016 |
| these results identify SEMA3E as an essential gene for GnRH neuron development, uncover a neurotrophic function for SEMA3E in the developing brain | Dysfunctional SEMA3E signaling underlies gonadotropin-releasing hormone neuron deficiency in Kallmann syndrome.
Cariboni A, André V, Chauvet S, Cassatella D, Davidson K, Caramello A, Fantin A, Bouloux P, Mann F, Ruhrberg C., Free PMC Article | 08/15/2015 |
| Sema3E is a natural negative regulator of the migration of PlexinD1-positive Cajal-Retzius (CR) cells originating in the cortical hem. Sema3E/PlexinD1 signaling controls the motogenic potential of CR cells in vitro and in vivo. | Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex.
Bribián A, Nocentini S, Llorens F, Gil V, Mire E, Reginensi D, Yoshida Y, Mann F, del Río JA. | 07/25/2015 |
| Our results indicate that Sema3e, secreted by damaged hepatocytes, affects sinusoidal regeneration in a paracrine manner during liver regeneration | Semaphorin 3E secreted by damaged hepatocytes regulates the sinusoidal regeneration and liver fibrosis during liver regeneration.
Yagai T, Miyajima A, Tanaka M. | 04/4/2015 |
| Semaphorin 3d requires neuropilin 1 or PI3K/Akt, whereas semaphorin 3e requires plexin D1 in directing endothelial motility. | Semaphorin 3d and semaphorin 3e direct endothelial motility through distinct molecular signaling pathways.
Aghajanian H, Choi C, Ho VC, Gupta M, Singh MK, Epstein JA., Free PMC Article | 10/18/2014 |
| Proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools. | Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling.
Fukuhara K, Imai F, Ladle DR, Katayama K, Leslie JR, Arber S, Jessell TM, Yoshida Y., Free PMC Article | 08/30/2014 |
| Sema3E acts as a chemoattractant for macrophages, with p53-induced upregulation of Sema3E expression provoking adipose tissue inflammation and systemic insulin resistance in association with dietary obesity. | Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity.
Shimizu I, Yoshida Y, Moriya J, Nojima A, Uemura A, Kobayashi Y, Minamino T. | 04/26/2014 |
| beta1 integrin adhesion is controlled by the plexinD1-sema3E axis in mice | Dynamic control of β1 integrin adhesion by the plexinD1-sema3E axis.
Choi YI, Duke-Cohan JS, Chen W, Liu B, Rossy J, Tabarin T, Ju L, Gui J, Gaus K, Zhu C, Reinherz EL., Free PMC Article | 03/15/2014 |
| Sema3E(-) (/) (-) mice survive throughout development and into adulthood, despite severe initial vascular defects. | Resolution of defective dorsal aortae patterning in Sema3E-deficient mice occurs via angiogenic remodeling.
Meadows SM, Ratliff LA, Singh MK, Epstein JA, Cleaver O., Free PMC Article | 11/16/2013 |
| Sema3E mRNA was highly downregulated in plaque macrophages | Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention.
Wanschel A, Seibert T, Hewing B, Ramkhelawon B, Ray TD, van Gils JM, Rayner KJ, Feig JE, O'Brien ER, Fisher EA, Moore KJ., Free PMC Article | 06/15/2013 |
| Sema3e is a novel inhibitor of osteoclast formation in vitro and may play a role in maintaining local bone homeostasis | A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro.
Hughes A, Kleine-Albers J, Helfrich MH, Ralston SH, Rogers MJ., Free PMC Article | 05/19/2012 |
| Sema3E-generated avascular zones are critical regulators of mammalian cardiovascular patterning and are the first to identify a repulsive role for the lateral plate mesoderm. | Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels.
Meadows SM, Fletcher PJ, Moran C, Xu K, Neufeld G, Chauvet S, Mann F, Krieg PA, Cleaver O., Free PMC Article | 03/31/2012 |
| This study demonstrated that Sema3E and Plexin-D1 specify the degree of glutamatergic connectivity between a specific source and target in the complex circuitry of the basal ganglia. | Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum.
Ding JB, Oh WJ, Sabatini BL, Gu C., Free PMC Article | 03/24/2012 |