| Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma. | Sema3C signaling is an alternative activator of the canonical WNT pathway in glioblastoma.
Hao J, Han X, Huang H, Yu X, Fang J, Zhao J, Prayson RA, Bao S, Yu JS., Free PMC Article | 05/5/2023 |
| Spatial association of SEMA3C with nerve endings/terminal Schwann cells in hair follicle isthmus region. | Spatial association of SEMA3C with nerve endings/terminal Schwann cells in hair follicle isthmus region.
Zhong HB, Chu QS, Xiang JJ, Zhang AL, Chen EQ, Shen XR, Liao XH. | 10/9/2021 |
| Post-crossing CCAs switch off their response to axon guidance cues, among which the secreted Semaphorin-3C (Sema3C), that act as attractants for pre-crossing axons on their way to the midline. This change is concomitant with an upregulation of the surface protein Ephrin-B1, which acts in CCAs to inhibit Sema3C signaling via interaction with the Neuropilin-1 (Nrp1) receptor. | Developmental Upregulation of Ephrin-B1 Silences Sema3C/Neuropilin-1 Signaling during Post-crossing Navigation of Corpus Callosum Axons.
Mire E, Hocine M, Bazellières E, Jungas T, Davy A, Chauvet S, Mann F. | 10/12/2019 |
| Taken together, epithelium-expressed SEMA3C plays a role in corneal epithelial wound closure and sensory nerve regeneration. | Opposing Effects of Neuropilin-1 and -2 on Sensory Nerve Regeneration in Wounded Corneas: Role of Sema3C in Ameliorating Diabetic Neurotrophic Keratopathy.
Lee PS, Gao N, Dike M, Shkilnyy O, Me R, Zhang Y, Yu FX., Free PMC Article | 09/21/2019 |
| Sema3c is a candidate that mediates interaction between cardiac neural crest cells and the second heart field during development of the outflow tract. | Regulation of Sema3c and the Interaction between Cardiac Neural Crest and Second Heart Field during Outflow Tract Development.
Kodo K, Shibata S, Miyagawa-Tomita S, Ong SG, Takahashi H, Kume T, Okano H, Matsuoka R, Yamagishi H., Free PMC Article | 02/9/2019 |
| analyzed a complementary set of ligand-specific and tissue-specific mutants to show that neural crest-derived SEMA3C activates NRP1 in the cardiac outflow tract endothelium | Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation.
Plein A, Calmont A, Fantin A, Denti L, Anderson NA, Scambler PJ, Ruhrberg C., Free PMC Article | 09/26/2015 |
| Sema3A overrides the effects of Sema3C in cortical axons exposed to defined mixtures of these opposing guidance cues in vitro | Integration of opposing semaphorin guidance cues in cortical axons.
Ruediger T, Zimmer G, Barchmann S, Castellani V, Bagnard D, Bolz J. | 08/3/2013 |
| No changes were observed in the binding of Sema3C to Nrp1-silenced B16(F10) cells, nor in its chemorepellent activity. | The influence of neuropilin-1 silencing on semaphorin 3A and 3C activity in B16(F10) murine melanoma cells.
Mazurek AM, Olbryt M. | 07/14/2012 |
| Data suggest that the formation and synaptic specificity of the GABAergic septohippocampal pathway relies on robust molecular mechanisms, independent of semaphorin 3C. | Semaphorin 3C is not required for the establishment and target specificity of the GABAergic septohippocampal pathway in vitro.
Rubio SE, Martínez A, Chauvet S, Mann F, Soriano E, Pascual M. | 04/7/2012 |
| the guidance factor Semaphorin 3C, which is expressed by corpus callosum neurons, acts through the neuropilin 1 receptor to orient axons crossing through the corpus callosum. | Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C.
Niquille M, Garel S, Mann F, Hornung JP, Otsmane B, Chevalley S, Parras C, Guillemot F, Gaspar P, Yanagawa Y, Lebrand C., Free PMC Article | 02/1/2010 |
| mutations in GATA6 are genetic causes of congenital heart diseases involving outflow tract defects, as a result of the disruption of the direct regulation of semaphorin 3C-plexin A2 signaling | GATA6 mutations cause human cardiac outflow tract defects by disrupting semaphorin-plexin signaling.
Kodo K, Nishizawa T, Furutani M, Arai S, Yamamura E, Joo K, Takahashi T, Matsuoka R, Yamagishi H., Free PMC Article | 01/21/2010 |
| The endocytic pathway of neuropilin(Nrp)1 depends on its ligand: sema3C induces lipid raft-dependent endocytosis. | Vascular endothelial growth factor and semaphorin induce neuropilin-1 endocytosis via separate pathways.
Salikhova A, Wang L, Lanahan AA, Liu M, Simons M, Leenders WP, Mukhopadhyay D, Horowitz A., Free PMC Article | 01/21/2010 |
| Npn1-dependent morphogenesis is mediated by Sema3A and Sema3C in an additive manner. | Semaphorin signaling facilitates cleft formation in the developing salivary gland.
Chung L, Yang TL, Huang HR, Hsu SM, Cheng HJ, Huang PH. | 01/21/2010 |
| GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis | GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis.
Lepore JJ, Mericko PA, Cheng L, Lu MM, Morrisey EE, Parmacek MS., Free PMC Article | 01/21/2010 |
| Taken together, our results reveal a molecular interaction between MMPs and semaphorins providing new insight into the molecular mechanism allowing axonal growth cone to respond to environmental guidance cues in the context of cortical development. | Functional interaction between matrix metalloproteinase-3 and semaphorin-3C during cortical axonal growth and guidance.
Gonthier B, Nasarre C, Roth L, Perraut M, Thomasset N, Roussel G, Aunis D, Bagnard D. | 01/21/2010 |
| Secreted sema3C favors cell survival and neuritogenesis of cultured cerebellar granule neurons | Semaphorin 3C preserves survival and induces neuritogenesis of cerebellar granule neurons in culture.
Moreno-Flores MT, Martín-Aparicio E, Martín-Bermejo MJ, Agudo M, McMahon S, Avila J, Díaz-Nido J, Wandosell F. | 01/21/2010 |
| sema 3C promotes glomerular endothelial cell proliferation, adhesion, directional migration, and tube formation in vitro by stimulating integrin phosphorylation and VEGF120 secretion | Semaphorin 3C regulates endothelial cell function by increasing integrin activity.
Banu N, Teichman J, Dunlap-Brown M, Villegas G, Tufro A. | 01/21/2010 |