| Brain border-derived CXCL2[+] neutrophils drive NET formation and impair vascular reperfusion following ischemic stroke. | Brain border-derived CXCL2(+) neutrophils drive NET formation and impair vascular reperfusion following ischemic stroke.
Huang T, Guo Y, Xie W, Yin J, Zhang Y, Chen W, Huang D, Li P., Free PMC Article | 09/23/2024 |
| Early infiltrating NKT lymphocytes attenuate bone regeneration through secretion of CXCL2. | Early infiltrating NKT lymphocytes attenuate bone regeneration through secretion of CXCL2.
Lin W, Li Q, Liu L, Wang Q, Zhang D, Wang F, Xu R, Fan Y, Xing M, Zhou C, Yuan Q., Free PMC Article | 08/15/2024 |
| Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2. | Tumor-associated macrophages mediate gastrointestinal stromal tumor cell metastasis through CXCL2/CXCR2.
Cai H, Chen Y, Chen X, Sun W, Li Y. | 02/25/2023 |
| Fpr2/CXCL1/2 Controls Rapid Neutrophil Infiltration to Inhibit Streptococcus agalactiae Infection. | Fpr2/CXCL1/2 Controls Rapid Neutrophil Infiltration to Inhibit Streptococcus agalactiae Infection.
Sun Z, Huang W, Zheng Y, Liu P, Yang W, Guo Z, Kong D, Lv Q, Zhou X, Du Z, Jiang H, Jiang Y., Free PMC Article | 02/19/2022 |
| Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis. | Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis.
Chen J, Jin J, Zhang X, Yu H, Zhu X, Yu L, Chen Y, Liu P, Dong X, Cao X, Gu Y, Bao X, Xia S, Xu Y., Free PMC Article | 02/12/2022 |
| Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion. | Cathepsin C aggravates neuroinflammation via promoting production of CCL2 and CXCL2 in glial cells and neurons in a cryogenic brain lesion.
Zhao X, Liu S, Yang X, Liu Y, Liu G, Fan K, Ma J. | 01/29/2022 |
| Cis-acting lnc-Cxcl2 restrains neutrophil-mediated lung inflammation by inhibiting epithelial cell CXCL2 expression in virus infection. | Cis-acting lnc-Cxcl2 restrains neutrophil-mediated lung inflammation by inhibiting epithelial cell CXCL2 expression in virus infection.
Liu S, Liu J, Yang X, Jiang M, Wang Q, Zhang L, Ma Y, Shen Z, Tian Z, Cao X., Free PMC Article | 12/18/2021 |
| Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis. | Macrophagic Extracellular Vesicle CXCL2 Recruits and Activates the Neutrophil CXCR2/PKC/NOX4 Axis in Sepsis.
Wang G, Huang W, Wang S, Wang J, Cui W, Zhang W, Lou A, Geng S, Li X., Free PMC Article | 11/13/2021 |
| Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions. | Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions.
Sawant KV, Sepuru KM, Lowry E, Penaranda B, Frevert CW, Garofalo RP, Rajarathnam K., Free PMC Article | 05/8/2021 |
| PXR Functionally Interacts with NF-kappaB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice. | PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Okamura M, Shizu R, Abe T, Kodama S, Hosaka T, Sasaki T, Yoshinari K., Free PMC Article | 04/13/2021 |
| Herbal Combinational Medication of Glycyrrhiza glabra, Agastache rugosa Containing Glycyrrhizic Acid, Tilianin Inhibits Neutrophilic Lung Inflammation by Affecting CXCL2, Interleukin-17/STAT3 Signal Pathways in a Murine Model of COPD. | Herbal Combinational Medication of Glycyrrhiza glabra, Agastache rugosa Containing Glycyrrhizic Acid, Tilianin Inhibits Neutrophilic Lung Inflammation by Affecting CXCL2, Interleukin-17/STAT3 Signal Pathways in a Murine Model of COPD.
Kim SH, Hong JH, Yang WK, Geum JH, Kim HR, Choi SY, Kang YM, An HJ, Lee YC., Free PMC Article | 01/9/2021 |
| These results show that CXCL2 attenuates osteoblast differentiation through inhibition of the ERK1/2 signaling pathway. | CXCL2 attenuates osteoblast differentiation by inhibiting the ERK1/2 signaling pathway.
Yang Y, Zhou X, Li Y, Chen A, Liang W, Liang G, Huang B, Li Q, Jin D. | 07/11/2020 |
| SHP regulates Cxcl2 transcription in hepatocytes, playing a pivotal role in the recruitment of neutrophils. SHP-targeting strategies may represent alternative approaches to control fulminant hepatitis | Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation.
Noh JR, Kim YH, Kim DK, Hwang JH, Kim KS, Choi DH, Lee SJ, Lee HG, Lee TG, Weng HL, Dooley S, Choi HS, Lee CH., Free PMC Article | 11/9/2019 |
| Study shows that TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines. | TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.
Tsutsui M, Hirase R, Miyamura S, Nagayasu K, Nakagawa T, Mori Y, Shirakawa H, Kaneko S., Free PMC Article | 10/26/2019 |
| Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 are involved in neutrophil emigration. | Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis.
Girbl T, Lenn T, Perez L, Rolas L, Barkaway A, Thiriot A, Del Fresno C, Lynam E, Hub E, Thelen M, Graham G, Alon R, Sancho D, von Andrian UH, Voisin MB, Rot A, Nourshargh S., Free PMC Article | 06/1/2019 |
| CXCL1, CXCL2 and CCL2 binding to the glomerular endothelial glycocalyx appears differentially mediated by specific Heparan sulfate domains. | Differential binding of chemokines CXCL1, CXCL2 and CCL2 to mouse glomerular endothelial cells reveals specificity for distinct heparan sulfate domains.
van Gemst JJ, Kouwenberg M, Rops ALWMM, van Kuppevelt TH, Berden JH, Rabelink TJ, Loeven MA, van der Vlag J., Free PMC Article | 02/16/2019 |
| Tumor cell-expressed transient receptor potential channel, melastatin subfamily type 2 (TRPM2) regulates neutrophil chemoattraction via chemokine CXCL2 (CXCL2). | TRPM2 modulates neutrophil attraction to murine tumor cells by regulating CXCL2 expression.
Gershkovitz M, Fainsod-Levi T, Zelter T, Sionov RV, Granot Z., Free PMC Article | 02/2/2019 |
| The studies revealed that, although overall structural and oligomerization features of CXCL3 and CXCL2 are similar, prominent differences were observed in their surface characteristics, thus implicating a functional divergence. | Molecular cloning and biophysical characterization of CXCL3 chemokine.
Gulati K, Gangele K, Agarwal N, Jamsandekar M, Kumar D, Poluri KM. | 07/28/2018 |
| TIARP independently down-regulated CXCL2 and IL-6 production by fibroblast-like synoviocytes, and the expression of chemokine receptors (CXCR1 and CXCR2) in neutrophils, with resultant reduction of neutrophil migration into arthritic joints. | TIARP attenuates autoantibody-mediated arthritis via the suppression of neutrophil migration by reducing CXCL2/CXCR2 and IL-6 expression.
Inoue A, Matsumoto I, Tanaka Y, Umeda N, Takai C, Kawaguchi H, Ebe H, Yoshida H, Matsumoto Y, Segawa S, Takahashi S, Sumida T., Free PMC Article | 06/9/2018 |
| a paracrine role for Hippo-mediated secretion of CXCL1 and CXCL2 in the production of anti-microbial peptides (beta-defensins), iNOS, NOX2 and pro-inflammatory molecules during mycobacterial infection of the host, is reported. | Mycobacterium tuberculosis-triggered Hippo pathway orchestrates CXCL1/2 expression to modulate host immune responses.
Boro M, Singh V, Balaji KN., Free PMC Article | 06/2/2018 |
| Taken together, the data of the present study demonstrated that TcpC can induce MIP2 production, which may contribute to the characteristic histological change associated with pyelonephritis. | TcpC secreting uropathogenic E. coli promoted kidney cells to secrete MIP-2 via p38 MAPK pathway.
He Y, Fang J, Zhang C, Pan J, Jin Q, Yang Y, Wang L, Wang B, Zhang D, Pan J. | 04/28/2018 |
| mip-2 siRNA and the MIP-2 antibody can reduce the inflammatory effects induced by lipopolysaccharide in macrophage cells. | Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide.
Chaochao Q, Lou G, Yang Y, Liu Y, Hu Y, Min Z, Chen P, He J, Chen Z. | 11/11/2017 |
| this study demonstrates that in vivo blocking of CXCL1 and CXCL2 can significantly reduce the Mycobacterium tuberculosis-induced bioactive IL-1beta production | CXCL1 and CXCL2 Regulate NLRP3 Inflammasome Activation via G-Protein-Coupled Receptor CXCR2.
Boro M, Balaji KN. | 09/30/2017 |
| These data identify suppression of CXCL2 and CXCL5 chemoattractant expression by 11beta-HSD1 as a novel mechanism with potential for regulation of neutrophil recruitment to the injured myocardium, and cardiac fibroblasts as a key site for intracellular glucocorticoid regeneration during acute inflammation following myocardial injury. | 11β-HSD1 suppresses cardiac fibroblast CXCL2, CXCL5 and neutrophil recruitment to the heart post MI.
Mylonas KJ, Turner NA, Bageghni SA, Kenyon CJ, White CI, McGregor K, Kimmitt RA, Sulston R, Kelly V, Walker BR, Porter KE, Chapman KE, Gray GA., Free PMC Article | 09/16/2017 |
| findings show that SRC-3 contributes to host defense against enteric bacteria, at least in part via upregulating CXCL2 expression to recruit neutrophils | Steroid Receptor Coactivator 3 Contributes to Host Defense against Enteric Bacteria by Recruiting Neutrophils via Upregulation of CXCL2 Expression.
Chen W, Lu X, Chen Y, Li M, Mo P, Tong Z, Wang W, Wan W, Su G, Xu J, Yu C., Free PMC Article | 09/2/2017 |