| EMP3 as a prognostic biomarker correlates with EMT in GBM. | EMP3 as a prognostic biomarker correlates with EMT in GBM.
Li L, Xia S, Zhao Z, Deng L, Wang H, Yang D, Hu Y, Ji J, Huang D, Xin T., Free PMC Article | 01/29/2024 |
| EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma. | EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastoma.
Martija AA, Krauß A, Bächle N, Doth L, Christians A, Krunic D, Schneider M, Helm D, Will R, Hartmann C, Herold-Mende C, von Deimling A, Pusch S., Free PMC Article | 11/14/2023 |
| Yes, MAM: how the cancer-related EMP3 protein became a regulator of erythropoiesis and the key protein underlying a new blood group system. | Yes, MAM: how the cancer-related EMP3 protein became a regulator of erythropoiesis and the key protein underlying a new blood group system.
Ilsley MD, Storry JR, Olsson ML. | 02/16/2023 |
| Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer. | Expression of epithelial membrane protein (EMP) 1, EMP 2, and EMP 3 in thyroid cancer.
Kim EK, Koo JS. | 04/9/2022 |
| EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties. | EMP3 negatively modulates breast cancer cell DNA replication, DNA damage repair, and stem-like properties.
Zhou K, Sun Y, Dong D, Zhao C, Wang W., Free PMC Article | 01/29/2022 |
| Epithelial membrane protein 3 regulates lung cancer stem cells via the TGFbeta signaling pathway. | Epithelial membrane protein 3 regulates lung cancer stem cells via the TGF‑β signaling pathway.
Kahm YJ, Kim RK, Jung U, Kim IG. | 01/29/2022 |
| Establishment of a nomogram with EMP3 for predicting clinical outcomes in patients with glioma: A bi-center study. | Establishment of a nomogram with EMP3 for predicting clinical outcomes in patients with glioma: A bi-center study.
Zhang A, Xu H, Zhang Z, Liu Y, Han X, Yuan L, Ni Y, Gao S, Xu Y, Chen S, Jiang J, Chen Y, Zhang X, Lou M, Zhang J., Free PMC Article | 01/29/2022 |
| Identification of candidate biomarker EMP3 and its prognostic potential in clear cell renal cell carcinoma. | Identification of candidate biomarker EMP3 and its prognostic potential in clear cell renal cell carcinoma.
Lv Q, Xiao W, Xiong Z, Shi J, Miao D, Meng X, Yuan H, Yang H, Zhang X. | 01/22/2022 |
| EMP3 mediates glioblastoma-associated macrophage infiltration to drive T cell exclusion. | EMP3 mediates glioblastoma-associated macrophage infiltration to drive T cell exclusion.
Chen Q, Jin J, Huang X, Wu F, Huang H, Zhan R., Free PMC Article | 12/11/2021 |
| The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma. | The Multifunctional Role of EMP3 in the Regulation of Membrane Receptors Associated with IDH-Wild-Type Glioblastoma.
Martija AA, Pusch S., Free PMC Article | 07/3/2021 |
| Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype. | Disruption of the tumour-associated EMP3 enhances erythroid proliferation and causes the MAM-negative phenotype.
Thornton N, Karamatic Crew V, Tilley L, Green CA, Tay CL, Griffiths RE, Singleton BK, Spring F, Walser P, Alattar AG, Jones B, Laundy R, Storry JR, Möller M, Wall L, Charlewood R, Westhoff CM, Lomas-Francis C, Yahalom V, Feick U, Seltsam A, Mayer B, Olsson ML, Anstee DJ., Free PMC Article | 09/12/2020 |
| Results found that EMP3 interacts with proteins involved in trafficking and signaling regulation. Its knockdown downregulates mitogenic signaling pathways and reduces cell proliferation and migration of HT-1080 fibrosarcoma cell line. | Characterization of the epithelial membrane protein 3 interaction network reveals a potential functional link to mitogenic signal transduction regulation.
Christians A, Poisel E, Hartmann C, von Deimling A, Pusch S. | 11/2/2019 |
| This study identified and validated a three-gene (EMP3, GSX2 and EMILIN3) prognostic signature in Lower-Grade Gliomas. | Integrative Analysis of DNA Methylation and Gene Expression Identify a Three-Gene Signature for Predicting Prognosis in Lower-Grade Gliomas.
Zeng WJ, Yang YL, Liu ZZ, Wen ZP, Chen YH, Hu XL, Cheng Q, Xiao J, Zhao J, Chen XP. | 08/25/2018 |
| The studies implicating GAS3 protein family (EMP1, EMP2, EMP3 and PMP22) in cancer pathogenesis as well as probe the structural similarities between the family members were highlighted. | Review of the GAS3 Family of Proteins and their Relevance to Cancer.
Ashki N, Gordon L, Wadehra M., Free PMC Article | 02/3/2018 |
| High EMP3 expression is associated with high grade glioma. | Epithelial membrane protein 3 regulates TGF-β signaling activation in CD44-high glioblastoma.
Jun F, Hong J, Liu Q, Guo Y, Liao Y, Huang J, Wen S, Shen L., Free PMC Article | 10/14/2017 |
| epithelial membrane protein 3 is a downstream effector of TWIST1/2 in inducing epithelial-to-mesenchymal transition in gastric cancer. Epithelial membrane protein 3 upregulation might be associated with gastric cancer metastasis and is a potential indicator of unfavorable overall survival and progression-free survival in gastric cancer patients | EMP3 is induced by TWIST1/2 and regulates epithelial-to-mesenchymal transition of gastric cancer cells.
Han M, Xu W. | 07/29/2017 |
| Independent validation with glioma patients tissue (n = 70) and normal brain tissue (n = 19) found PPIC, EMP3 and CHI3L1 were up-regulated in glioma tissue. Survival value validation showed that the three genes correlated with patient survival by Kaplan-Meir analysis, including grades, age and therapy. | PPIC, EMP3 and CHI3L1 Are Novel Prognostic Markers for High Grade Glioma.
Gao YF, Zhu T, Mao CX, Liu ZX, Wang ZB, Mao XY, Li L, Yin JY, Zhou HH, Liu ZQ., Free PMC Article | 04/1/2017 |
| The study provided a new insight into EMP3, suggesting that EMP3 enhances malignancy of hepatocellular carcinoma cells | Targeting EMP3 suppresses proliferation and invasion of hepatocellular carcinoma cells through inactivation of PI3K/Akt pathway.
Hsieh YH, Hsieh SC, Lee CH, Yang SF, Cheng CW, Tang MJ, Lin CL, Lin CL, Chou RH., Free PMC Article | 09/3/2016 |
| EMP3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma. | Epithelial membrane protein 3 functions as an oncogene and is regulated by microRNA-765 in primary breast carcinoma.
Hong XC, Fen YJ, Yan GC, Hong H, Yan CH, Bing LW, Zhong YH., Free PMC Article | 08/13/2016 |
| The aim of this study was to investigate the EMP3 promoter hypermethylation status in a series of 229 astrocytic and oligodendroglial tumors and in 16 glioblastoma cell lines. | Promoter hypermethylation of the EMP3 gene in a series of 229 human gliomas.
Mellai M, Piazzi A, Caldera V, Annovazzi L, Monzeglio O, Senetta R, Cassoni P, Schiffer D., Free PMC Article | 04/19/2014 |
| Decreased expression of EMP3 by promoter methylation is associated by lung cancer | Epithelial membrane protein 3 is frequently shown as promoter methylation and functions as a tumor suppressor gene in non-small cell lung cancer.
Xue Q, Zhou Y, Wan C, Lv L, Chen B, Cao X, Ju G, Huang Y, Ni R, Mao G. | 02/1/2014 |
| LOH 19q determines the complete loss of EMP3 function, as the conserved allele is frequently hypermethylated, and this may represent the molecular basis of the higher risk of relapse in this subgroup of grade II oligodendroglioma patients. | LOH 19q indicates shorter disease progression-free interval in low-grade oligodendrogliomas with EMP3 methylation.
Pasini A, Iorio P, Bianchi E, Cerasoli S, Cremonini AM, Faedi M, Guarnieri C, Guiducci G, Riccioni L, Molinari C, Rengucci C, Calistri D, Giordano E. | 04/20/2013 |
| The promoter methylation and mRNA expressions of EMP3 and PCDH-gamma-A11 are closely related with the malignant development of glioma. | [The methylation analysis of EMP3 and PCDH-gamma-A11 gene in human glioma].
Jiang Z, Zhou W, Li XG, Jiang YQ, Wang L, Wang DH, Wang XY, Li XE. | 01/15/2011 |
| Epithelial membrane protein 3 overexpression in breast carcinomas was significantly related to histological grade III , lymph node metastasis , and strong Her-2 expression. | EMP3 overexpression in primary breast carcinomas is not associated with epigenetic aberrations.
Zhou W, Jiang Z, Li X, Xu F, Liu Y, Wen P, Kong L, Hou M, Yu J., Free PMC Article | 01/21/2010 |
| Loss of EMP3 is associated with esophageal squamous cell carcinoma. | EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma.
Fumoto S, Hiyama K, Tanimoto K, Noguchi T, Hihara J, Hiyama E, Noguchi T, Nishiyama M. | 01/21/2010 |